BRUCINE

作品数：17被引量：118H指数：5
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相关领域：医药卫生更多>>
相关作者：蔡宝昌殷武邓旭坤朱燕娜孙靓更多>>
相关机构：南京中医药大学南京大学河南医科大学河南省医学科学研究所更多>>
相关期刊：《河南医学研究》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《中国药理学通报》更多>>
相关基金：国家自然科学基金江苏省博士生创新基金更多>>
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ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron被引量：16
《Acta Pharmacologica Sinica》2021年第10期1690-1702,共13页Shan Lu Xuan-zhong Wang Chuan He Lei Wang Shi-peng Liang Chong-cheng Wang Chen Li Tian-fei Luo Chun-sheng Feng Zhen-chuan Wang Guang-fan Chi Peng-fei Ge 
This work was supported by the National Natural Science Foundation of China(81772669 and 81972346);Changbaishan Scholar Project of Jilin Province(2013026);Scientific Research Foundation of Jilin Province(20190701051GH and 20200201405JC);the Achievement Transformation Fund of the First Hospital of Jilin University(CGZHYD202012-028).
Ferroptotic cell death is characterized by iron-dependent lipid peroxidation that is initiated by ferrous iron and H_(2)O_(2) via Fenton reaction,in which the role of activating transcription factor 3(ATF3)remains elu...
关键词：GLIOMA BRUCINE ferroptosis ATF3 hydrogen peroxide ER stress NOX4 
Effect of Baizhu(Rhizoma Atractylodis Macrocephalae)extract on intestinal absorption of brucine and strychnine in vitro and in situ被引量：4
《Journal of Traditional Chinese Medicine》2020年第4期562-570,共9页Lu Dan Jiang Qieying Zhang Jing Zeng Ronggui Liao Zhenggen Liang Xinli 
the National Natural Science Foundation of China(No.81660757 and No.81303237);the Academic and Technological Foregoer Funds of Jiangxi Province,China(No.20162BCB22015);the Project on Cultivation of Medical Elite(Gan Po Ying Cai 555)(2013296);the Youth Science Funds of Jiangxi Province,China(No.20153BCB23019);the National Natural Science Foundation of Jiangxi Province(No.20161ACB21020);the Natural Science Research Project of Huaian(No.HAB201716)。
OBJECTIVE:To investigate the antagonistic effect of the extract of Baizhu(Rhizoma Atractylodis Macrocephalae)(RAM)on the intestinal absorption of brucine and strychnine in Strychnos nux-vomica(NUX)and propose the mech...
关键词：Strychnos nux-vomica BRUCINE STRYCHNINE ATP binding cassette transporter subfamily B member 1 Baizhu(Rhizoma Atractylodis Macrocephalae) 
Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation被引量：5
《Current Medical Science》2019年第6期890-898,共9页Min ZHANG Chao WANG Hua-lin CAI Jing WEN Ping-fei FANG 
the National Natural Science Foundation of China(No.81473411).
Licorice,one of the most widely used medicinal herbs in East Asia,has effects such as anti-inflammation,antioxidant,and detoxifying.This study aimed to evaluate the protective effect of licorice on brucine-induced nep...
关键词：LICORICE BRUCINE NEPHROTOXICITY apoptosis STAT3 
Tissue distribution and pharmacokinetics of brucine niosomal gels in rats after topical and oral application被引量：1
《Journal of Chinese Pharmaceutical Sciences》2018年第2期92-98,共7页Zhenzhen Wu Hengchun Ren Yanying Li Jiajia Fu Xiaojun Liu Jie Hu 
National Science and Technology Major Projects for"Major New Drugs Innovation and Development"(Grant No.2017ZX09301016)
Brucine has anti-inflammatory and analgesic effects and is the main active compound of the seeds of Strychnos nux-vomica L. To study brucine niosomal gels, a reliable and rapid LC-MS/MS method was established to quant...
关键词：Brucine niosomal gels PHARMACOKINETICS Tissue distribution LC-MS/MS 
Brucine Suppresses Breast Cancer Metastasis via Inhibiting Epithelial Mesenchymal Transition and Matrix Metalloproteinases Expressions被引量：19
《Chinese Journal of Integrative Medicine》2018年第1期40-46,共7页LI Miao LI Ping ZHANG Mei MA Feng 
Supported by the State Administration of Traditional Chinese Medicine of China(2009-No.30)
Objective： To examine the effect of brucine on the migration, invasion, adhesion and expressions of epithelial-to-mesenchymal transition （EMT） markers and matrix metalloproteinases （MMPs） in the highly metastatic...
关键词：BRUCINE breast cancer METASTASIS epithelial mesenchymal transition matrix metalloproteinase 
Brucine N-oxide reduces ethanol intake and preference in alcohol-preferring Fawn-Hooded rats
《中国药理学与毒理学杂志》2017年第5期479-480,共2页LIANG Jian-hui WEI Shou-peng LI Yu-ling GONG Qi WANG Yan-ting LIANG Hui LIU Qing ZHANG Han-ting CHEN Feng Andrew J LOWRENCE 
OBJECTIVE The alcoholism-related social problems have burdened the public health heavily.A better therapy for alcohol dependence as a chronic brain disease is highly required and interests the scientists worldwide. Ou...
关键词：brucine N-oxide ethanol 
Brucine Inhibits Bone Metastasis of Breast Cancer Cells by Suppressing Jagged1/Notch1 Signaling Pathways被引量：18
《Chinese Journal of Integrative Medicine》2017年第2期110-116,共7页HU Ke-fei KONG Xiang-ying ZHONG Mi-cun WAN Hong-ye LIN Na PEI Xiao-hua 
Supported by the Fifty-fifth Batch of China Post Doctoral Science Foundation(No.2014M550663)
Objective： To examine the effects of brucine on the invasion, migration and bone resorption of receptor activator of nuclear factor-kappa B ligand（RANKL）-induced osteoclastogenesis. Methods： The osteoclastogenesis...
关键词：brucine breast cancer bone metastasis Jagged1/Notch1 signaling pathway 
Microstructure, Content and in vitro Release of Brucine and Strychnine in Strychnos Nux-Vomica Powder with Different Particle Sizes被引量：4
《Transactions of Tianjin University》2014年第6期444-450,共7页倪力军 赵雯雯 张立国 王南南 
Supported by the Plan Issue of Shanghai Science &Technology Committee(No.13401901100)
To explore the effect of particle size on the quality uniformity and in vitro release performance of Strychnos nux-vomica powder, seven samples of Strychnos nux-vomica powder with different particle sizes were prepare...
关键词：strychnos nux-vomica BRUCINE STRYCHNINE PARTICLE size quality UNIFORMITY in VITRO release 
Brucine抗肿瘤的分子水平研究进展被引量：2
《中国老年学杂志》2014年第17期5022-5024,共3页杨福伟 王辰 王光明 王德友 王皓 
传统中药马钱子,为马钱科植物马钱子的干燥成熟种子,具有通络止痛、散结消肿的功效。现代研究表明其主要有效成分为生物碱类,含量约为生药的1.5%~5%,主要是士的宁、马钱子碱(Brucine)及其氮氧化物。其中Brucine是从马钱子中提取的吲哚...
关键词：马钱子碱(Brucine) 抗肿瘤作用机制 分子水平 
Erucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats被引量：3
《Acta Pharmacologica Sinica》2014年第7期853-861,共9页Yu-ling LI Qing LIU Qi GONG Jun-xu LI Shou-peng WEI Yan-ting WANG Hui LIANG Min ZHANG Li JING ZhengYONG Andrew J LAWRENCE Jian-hui LIANG 
Aim： Brucine （BRU） extracted from the seeds of Strychnos nux-vomica L is glycine receptor antagonist. We hypothesize that BRU may modify alcohol consumption by acting at glycine receptors, and evaluated the pharmac...
关键词：ALCOHOLISM ethanol BRUCINE glycine receptor antagonist Fawn-Hooded （FH/Wjd） rat 
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