Supported by the Thailand Research Fund,No.DBG5980006;UK-Thailand Research Collaborations(Newton Fund),No.MR/N01247X/1.
BACKGROUND In the past decades,the potential of microRNA(miRNA)in cancer diagnostics and prognostics has gained a lot of interests.In this study,a meta-analysis was conducted upon the pooled miRNA microarray data of c...
Supported by Postgraduate Research and Practice Innovation Program of Jiangsu Province,No.KYCX18_0174
BACKGROUND Statistics indicate that the incidence of Crohn’s disease(CD)is rising in many countries.The poor understanding on the pathological mechanism has limited the development of effective therapy against this d...
Supported by A Strategic Alliance Programme between Alltech Ltd. and DCU and also Enterprise Ireland Innovation Partnership Grant(IP 2015 0375)
AIM To identify mi RNA-regulated proteins differentially expressed between Caco2 and HT-29: two principal cell line models of the intestine.METHODS Exponentially growing Caco-2 and HT-29 cells were harvested and prepa...
Supported by the Deutsche Forschungsgemeinschaft,No.(DFG) SFB-TRR77 “Liver cancer”(Project B1)
To screen clinically relevant microRNAs (miRNAs) silenced by DNA methylation in human hepatocellular carcinoma (HCC).METHODSKnockdown of DNA methyltransferases (DNMTs) using siRNAs and miRNA profiling in HCC cell line...
Supported by Projects of Foreign Science and Technology Cooperation of Anhui Province of Anhui Province,No.1604b0602027;New Century Excellent Talents in University,Ministry of Education of China,No.NCET-13-0644;Wanjiang Scholars Program of Anhui Province of China
AIM To explore novel therapeutic target of cisplatin resistance in human gastric cancer.METHODS The sensitivity of SGC7901 cells and cisplatin-resistant SGC7901 cells(SGC7901/DDP) for cisplatin were detected by 3-(4,5...
Supported by National Natural Science Foundation of China,No.81370008 and No.81000169;Natural Science Foundation of Zhejiang Province,No.R2110159,No.LY15H030006 and No.LY16H030003;Science Technology Project of Zhejiang Province,No.2014C33205
AIM: To investigate the expression pattern of plasma long noncoding RNAs (lncRNAs) in Chrohn’s disease (CD) patients.METHODS: Microarray screening and qRT-PCR verification of lncRNAs and mRNAs were performed i...
Supported by National Institutes of Health,Bethesda,United States,No.5R01AI076192
AIM: To study host gene expression and numberof immune cells in liver tissues from patients with fulminant hepatitis E(FH-E).METHODS: Microarray-based expression profiling was done using Illumina Human WG-6_v3_Bead Ch...
Grants from the research projects in Liaoning Province Science and Technology Department,No.2007225017,No.2009225011-2 and No.2011415052;Science and Technology projects in Shenyang City,No.F11-264-1-19
AIM:To investigate the expression and prognostic role of pyruvate dehydrogenase(PDH) in gastric cancer(GC).METHODS:This study included 265 patients(194 male,71 female,mean age 59 years(range,29-81 years) with GC who u...
Supported by Grants from the Ministry of Health of the China,No.W2012RQ02;Shanghai Science and Technology Committee,No.12nm0501402;Shanghai Education Committee,No.120311
AIM: To investigate the microRNA(miRNA) expression profile in gastrointestinal stromal tumor(GIST) tissues that could serve as a novel diagnostic biomarker for GIST detection.METHODS: We performed a quantitative real-...
Supported by National Natural Science Foundation of China,No.81071965
AIM: To profile expression of microRNAs (miRNAs) in gastric cancer cells and investigate the effect of miR-374b-5p on gastric cancer cell invasion and metastasis.