Α-GLUCOSIDASE

作品数:98被引量:178H指数:7
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相关领域:医药卫生更多>>
相关作者:陈光英郑彩娟罗由萍周通肖音更多>>
相关机构:哈尔滨工业大学中国科学院大叶大学海南师范大学更多>>
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相关基金:国家自然科学基金广东省自然科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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  • 期刊=Chinese Journal of Natural Medicinesx
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Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum
《Chinese Journal of Natural Medicines》2025年第2期245-256,共12页Jiaocen Guo Li Yang Luting Dai Qingyun Ma Jiaoyang Yan Qingyi Xie Yougen Wu Haofu Dai Youxing Zhao 
supported by the National Natural Science Foundation of China (No.81973568);the Earmarked Fund for China Agriculture Research System (No.CARS-21);the Special Financial Project of the Ministry of Agriculture and Rural Areas (No.NFZX2024)。
Eight previously undescribed lanostane triterpenoids,including five nortriterpenoids with 26carbons,ganothenoids A-E(1-5),and three lanostanoids,ganothenoids F-H(6-8),along with 24 known ones(9-32),were isolated from ...
关键词:Ganoderma theaecolum Lanostane nortriterpenoids Neuroprotective effects PTP1B Α-GLUCOSIDASE 
Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii
《Chinese Journal of Natural Medicines》2023年第6期443-453,共11页TAO Linlan XU Shuangyu ZHANG Zizhen LI Yanan YANG Jue GU Wei YI Ping HAO Xiaojiang YUAN Chunmao 
supported by the National Natural Science Foundation of China(No.32270413,U1812403);the Science and Technology Department of Guizhou Province(No.QKH 2020-1Z076);the 13th batch of Outstanding Young Scientific and Technological Talents in Guizhou Province(No.QKHPTRC[2021]5633);Cultivation project of National Natural Science Foundation of Guizhou Medical University(No.19NSP003);the Education Department of Guizhou Province(No.QJH KY[2021]189);the Natural Science Foundation of Guizhou Province(No.QKHZYD[2022]4015);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);“Light of the West”Talent Cultivation Program of Chinese Academy of Sciences for Chunmao Yuan(No.RZ[2020]82).
This study employed the α-glucosidase inhibitory activity model as an anti-diabetic assay and implemented a bioactivity-guided isolation strategy to identify novel natural compounds with potential therapeutic propert...
关键词:Hypericum sampsonii Chemical constituents Structure elucidation Α-GLUCOSIDASE Molecular docking 
Rapid identification of stigmastane-type steroid saponins from Vernonia amygdalina leaf based onα-glucosidase inhibiting activity and molecular networking
《Chinese Journal of Natural Medicines》2022年第11期846-853,共8页GAO Juanjuan ZHAO Mengling SHAN Shujun LI Yongyi LUO Jun LI Yi 
supported by the National Natural Science Foundation of China(No.81573550)。
Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines,especially Vernonia amygdalina,a famous nature medicine for the treatment of tonsilliti...
关键词:Δ^(7 9(11))Stigmastane-type steroid saponins α-Glucosidase inhibitory activity Fragmentation pathways Diagnostic ions Molecular networking 
New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242被引量:3
《Chinese Journal of Natural Medicines》2020年第11期855-859,共5页GUO Hui-Xian HUANG Cui-Ying YAN Zhang-Yuan CHEN Tao HONG Kui LONG Yu-Hua 
supported by the National Natural Science Foundation of China (No. 41876153);Guangdong Special Fund for Marine Economic Development (No. GDME-2018C004);the Natural Science Foundation of Guangdong Province (No.2017A030313088)。
Four new compounds, asperisocoumarin G(1), asperisocoumarin H(2),(±)-asperisocoumarin I [(±)-3], along with the known pergillin(4) and penicisochroman L(5) were isolated from a mangrove endophytic fungus Aspergillus...
关键词:ASPERGILLUS Furo[3 2-h]isocoumarins α-Glucosidase inhibitory activity Antimicrobial activity 
Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3被引量:2
《Chinese Journal of Natural Medicines》2020年第4期256-260,共5页QIU Pei CAI Run-Lin LI Lin SHE Zhi-Gang 
the National Natural Science Foundation of China (No. 21877133);Guangdong MEPP Fund (No. GDOE-2019A21);the Key Project of Natural Science Foundation of Guangdong Province (No. 2016A040403091) for generous support。
Three new isocoumarin derivatives,(S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one(1),(S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one(2) and(R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1 H-isochromen-3...
关键词:Isocoumarin derivatives Penicillium sp. Structure elucidation α-Glucosidase inhibitory activity 
Vitellaria paradoxa nutshells from seven sub-Saharan countries as potential herbal medicines for treating diabetes based on chemical compositions, HPLC fingerprints and bioactivity evaluation被引量:2
《Chinese Journal of Natural Medicines》2019年第6期446-460,共15页LI Da XIAO Jian-Qi LIU Wen-Yuan ZHANG Chao-Feng AKIHISA Toshihiro ABE Masahiko MASTERS Eliot-T. ZHAI Wei-Wei FENG Feng ZHANG Jie 
supported by the General Program Foundation of Jiangsu Food and Pharmaceutical Science College(No.JSFP·2018005-Z);the Natural Science Foundation of Jiangsu Province(No.BK20170742);the Youth Science Fund Project of National Natural Science Foundation of China(No.81703383)
The aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-TOF-MS and phyt...
关键词:Vitellaria paradoxa HPLC FINGERPRINTS Antioxidant ACTIVITY Α-GLUCOSIDASE INHIBITORY ACTIVITY Molecular DOCKING 
New octadecanoid derivatives from the seeds of Ipomoea nil
《Chinese Journal of Natural Medicines》2019年第4期303-307,共5页SONG Xiu-Qing ZHANG Jun-Sheng YU Shu-Juan YU Jin-Hai ZHANG Hua 
supported by the Natural Science Foundation of Shandong Province(No.JQ201721);the Young Taishan Scholars Program(No.tsqn20161037);the Director Foundation of XTIPC,CAS(No.2015RC015);Shandong Talents Team Cultivation Plan of University Preponderant Discipline(No.10027)。
Four new octadecanoid derivatives(1–4) including a pair of enantiomers(1/2), along with 12 known analogues(5–16), were isolated from the seeds of Ipomoea nil. Their structures were determined by detailed spectroscop...
关键词:Ipomoea nil Octadecanoid Fatty acid Natural enantiomer α-Glucosidase inhibition 
Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities被引量:2
《Chinese Journal of Natural Medicines》2017年第11期816-824,共9页XIONG Jia GRACE Mary H ESPOSITO Debora KOMARNYTSKY Slavko WANG Fei LILA Mary Ann 
supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);State Forestry Administration of China(No.201104019)
The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract(B) and fractions(B1-B7) obtained by high-speed counter-current chromatography(HSCCC) and evaluate their a...
关键词:ACACIA mearnsii PROANTHOCYANIDINS ANTI-INFLAMMATORY Α-AMYLASE Α-GLUCOSIDASE 
Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity被引量:4
《Chinese Journal of Natural Medicines》2016年第3期227-231,共5页LI Jie-Hong PAN Jie-Tao YIN Yong-Qin 
supported by Chinese National Natural Science Fund(No.81202885);the Natural Science Foundation of Guangdong province of China(No.2015A030313585)
In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and...
关键词:Ipomoea cairica Resin glycoside Simonic acid A a-Glucosidase 
Simultaneous quantification of ten constituents of Xanthoceras sorbifolia Bunge using UHPLC-MS methods and evaluation of their radical scavenging, DNA scission protective, and α-glucosidase inhibitory activities被引量:11
《Chinese Journal of Natural Medicines》2015年第11期873-880,共8页ZHANG Yu MA Jian-Nan MA Chun-Li QI Zhi MA Chao-Mei 
supported by National Natural Science Foundation of China(No.81360474)
The present study was designed to investigate the bioactive constituents ofXanthoceras sorbifolia in terms of amounts and their antioxidant, DNA scissiou protection, and ct-glucosidase inhibitory activities. Simultane...
关键词:Xanthoceras sorbifolia Constituents Quantification Antioxidant DNA scission protective α-glucosidase inhibition 
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