To investigate the effect on central nervous transmission of toosendanin (TSN), a presynaptic blocker, rat striatum was perfused in vivo with a TSN-containing artificial cere-brospinal fluid (ACSF) and the level of do...
This work was supported by National Institute for Physiological Science, Japan and the National Natural Science Foundation of China. Partial experiments were performed in Okazaki, Japan
Toosendanin (TSN), a triterpenoid derivative extracted from the bark of Melia toosendan Seib et Zucc and used in Chinese traditional medicine as an anthelmintic against ascaris, is a presynaptic neuromuscular blocker....
As the most potent natural poison, botulinum toxin (BoTX) blocks the cholinergic synaptic transmission in skeletal muscles selectively by interfering in the acetylcholine release from motor nerve terminals and results...