INFLAMMASOME

作品数：391被引量：2615H指数：23
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相关领域：医药卫生更多>>
相关作者：韩蓉吴东明吴玉章许颖陈永文更多>>
相关机构：第二军医大学广州医科大学华中科技大学安徽医科大学更多>>
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DDX3X: stressing the NLRP3 inflammasome被引量：4
《Cell Research》2019年第12期969-970,共2页Daniel Fox Si Ming Man 
Stress granules and inflammasomes are intracellular complexes that assemble in response to cellular stress signals,enabling cells to persist and perish,respectively.In a recent study published in Nature,Samir et al.id...
关键词：NLRP3 STRESS SOME 
Author Correction:Mitochondrial DNA synthesis fuels NLRP3 inflammasome被引量：2
《Cell Research》2018年第12期1202-1202,共1页Rebecca C.Coll Caroline L.Holley Kate Schroder 
In the initial published version of this article,there was a mistake in the title.The correct title should be "Mitochondrial DNA synthesis fuels NLRP3 activation".This correction does not affect the description of the...
关键词：AUTHOR CORRECTION MITOCHONDRIAL DNA SYNTHESIS fuels NLRP3 INFLAMMASOME 
Mitochondrial DNA synthesis fuels NLRP3 inflammasome被引量：3
《Cell Research》2018年第11期1046-1047,共2页Rebecca C. Coll Caroline L. Holley Kate Schroder 
Mitochondria-derived signals are associated with NLRP3 inflammasome activation. A recent study in Nature by Zhong et al. shows that inflammasome priming drives new mito- chondrial DNA synthesis, and proposes this to b...
关键词：Innate immunity 
NLRP9b： a novel RNA-sensing inflammasome complex被引量：5
《Cell Research》2017年第11期1302-1303,共2页Chinh Ngo Si Ming Man 
Inflammasome sensors recognize pathogens and danger signals and assemble an immune signaling com- plex, which induces the secretion of pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. A new study published...
Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation被引量：20
《Cell Research》2017年第6期784-800,共17页Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu 
Chemotherapies are known often to induce severe gastrointestinal tract toxicity but the underlying mechanism re- mains unclear. This study considers the widely applied cytotoxic agent irinotecan （CPT-11） as a repres...
关键词：DSDNA AIM2 EXOSOME INFLAMMASOME CHEMOTHERAPY intestinal toxicity 
The kinase activity of PKR represses inflammasome activity被引量：1
《Cell Research》2016年第3期367-379,共13页Howard CH Yim Die Wang Liang Yu Christine L White Pieter W Faber Bryan RG Williams Anthony J Sadler 
The protein kinase R （PKR） functions in the antiviral response by controlling protein translation and inflamma- tory cell signaling pathways. We generated a transgenic, knock-in mouse in which the endogenous PKR is ...
关键词：INFLAMMATION INFLAMMASOMES protein kinase R kinase activity protein translation 
Inflammasome assembly： The wheels are turning被引量：1
《Cell Research》2015年第12期1277-1278,共2页Petr Broz 
Inflammasomes control host cell death and inflammation in response to sterile or infectious stimuli. Two recent reports published in Science reveal the structural basis for the assembly of NAIP-NLRC4 inflammasomes.
关键词：下线 服务 迁移 
Gasdermin D is an executor of pyroptosis and required for interleukin-lp secretion被引量：252
《Cell Research》2015年第12期1285-1298,共14页Wan-ting He Haoqiang Wan Lichen Hu Pengda Chen Xin Wang Zhe Huang Zhang-Hua Yang Chuan-Qi Zhong Jiahuai Han 
Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of interleukin 1β （IL-Iβ） and IL-18 and triggers pyroptosis. Caspase-1 and -11 （o...
关键词：GSDMD INFLAMMASOME PYROPTOSIS apoptosis IL-1 β CASPASE-1 caspase-11 
Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome被引量：7
《Cell Research》2013年第7期965-968,共4页Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng 
We thank Dr Warren Strober （National Institutes of Health, USA） for providing the Nlrp3-deficient mice, Dr Vishva Dixit （Genentech, Inc., USA） for providing Asc-deficient mice, Dr Jfirg Tschopp （University of Lausanne, Switzerland） for provid- ing shRNA constructs. We also thank Dr Xudong Zhu （Nankai University, China） for helpful discussion and our colleague Ms Cuili Dong for excellent technical assistance. This work was sup- ported by grants from 100 Talent Program of the Chinese Acad-emy of Sciences, the National Natural Science Foundation of China （91029707, 31170868, 812111134, 31100622）, Shanghai Natural Science Foundation （11ZR1442600）, Novo Nordisk-CAS Research Foundation, SA-SIBS Scholarship Program, Chinese Postdoctoral Science Foundation （20110490752） and Postdoctoral Research Foundation of Shanghai Institutes for Biological Sci- ences （2011 KIP513）, as well as grants from the National Key Ba- sic Research Program （2013CB531600） and National Science and Technology Major Project （2012ZX 10002007-003） of China.
Dear Editor, Many opportunistic fungi are devastating pathogens that cause lethal infection. Cryptococcus neoformans （C. neoformans） is such a fungus that mainly infects im- munocompromised hosts such as AIDS patie...
关键词：隐球菌 生物膜 真菌病原体 激活 菌株 临床 器官移植 脑膜脑炎 
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock被引量：61
《Cell Research》2013年第2期201-212,共12页Kairui Mao Shuzhen Chen Mingkuan Chen Yonglei Ma Yan Wang Bo Huang Zhengyu He Yan Zeng Yu Htl Shuhui Sun Jing Li Xiaodong Wu Xiangrui Wang Warren Strober Chang Chen Guangxun Meng Bing Sun 
We thank R Caspi （National Eye Institute, NIH, USA） and D Li （Shanghai Institutes for Biological Sciences, China） for helpful comments, and S Skinner for critical reading of the manuscript. This work was supported by the National Basic Research Program of China （973 program, 2013CB530504）, the National Natural Science Foundation of China （31230024, 31030029, 31100662, 31030023, 91029707, 31170868）, the Shanghai Natural Science Foundation （11ZR1442600）, the National Ministry of Science and Technology （2007DFC31700）, the National Science and Technology Major Project （2008ZX10004-002, 2008ZX10002-014, 2009ZX10004-105, 2009ZXI0004-016, 2011ZX10004-001 and 2012ZXl0002007）, the Shanghai Pasteur Health Research Foundation （SPHRF2008001 and SPHRF2009001）, the SA-SIBS Discovery Innovation Grant, the Li Kha Shing Foundation and the 100 Talent Program of the Chinese Academy of Sciences （to GM）.
Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the maturation of interleukin-1β （IL-1β）, yet the regulation of these complexes remains poorly characterized. Here we show tha...
关键词：nitric oxide NLRP3 inflammasome septic shock 
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