云南高校图书馆联盟文献共享服务平台- INFLAMMASOME

INFLAMMASOME: 作品数：391被引量：2615H指数：23; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：韩蓉吴东明吴玉章许颖陈永文更多>>; 相关机构：第二军医大学广州医科大学华中科技大学安徽医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划上海市自然科学基金更多>>

14-Deoxygarcinol,a polyisoprenylated benzophenone from Garcinia cambogia,ameliorates inflammatory responses in adipose tissue via suppressing NLRP3 inflammasome: 《中国药理学与毒理学杂志》2021年第10期759-759,共1页CHEN Jia-li FENG Zhe-ling CHEN Cheng ZHU Jian-zhong LIN Li-gen; National Natural Science Foundation of China(81872754);Research Fund of University of Macao(MYRG2018-00037-ICMS);and Science and Technology Development Fund,Macao SAR(FDCT 0031/2019/A1)。; OBJECTIVE Interleukin(IL)-1β,one of the principal inflammatory cytokines mainly secreted by monocytes and macrophages,is produced by cleavage of the inactive pro-IL^(-1)βprecursor by caspase-1 via the NLRP3 inflamma...; 关键词：14-deoxygarcinol Sirtuin 2 INTERLEUKIN-1Β MACROPHAGES NLRP3 inflammasome

Myrrh extract alleviated ROS-mediated ferroptosis through regulating TXNIP/NLRP3 axis in ischemic stroke: 《中国药理学与毒理学杂志》2019年第9期667-668,共2页LIU Tian-long WANG Wen-jun DING Yi WEN Ai-dong ZHANG Ru-xue; National Natural Science Foundation of China(81673631;81603385);China Postdoctoral Science Foundation(2018M643843);Natural Science Foundation of Shaanxi Province(2017JM8056);Key Research and Development Foundation of Shaanxi province(2018SF-241); OBJECTIVE To investigate the neuroprotective effects and exact mechanisms of myrrh extract following cerebral ischemic stroke.METHODS Male rats were randomly divided into three groups:sham group,middle cerebral artery...; 关键词：myrrh extract ischemic stroke ferroptosis NLRP3 inflammasome thioredoxin-interacting protein reac⁃tive oxygen species

Naringenin protects LPS-induced dopaminergic neurons damage through mediating NLRP3 inflammasome: 《中国药理学与毒理学杂志》2018年第9期697-698,共2页CHEN Ce LI Dai-di WANG Guo-qing ZHANG Feng; National Natural Science Foundation of China(81460556;81760658).; OBJECTIVE To research the effect of naringenin(NAR) on LPS-induced dopaminergic neurons damage and its potential mechanism.METHODS Rats were randomly divided into the following six groups(n=10):control(0.9% NaCl),NAR ...; 关键词：NLRP3 INFLAMMASOME NARINGENIN DOPAMINERGIC NEURONS

Protective effect and mechanism of ginsenoside Rg1 on H2O2 induced hippocampal neurons aging due to down-regulate NOX2 mediated NLRP1 inflammasome activation in vitro被引量：1: 《中国药理学与毒理学杂志》2018年第4期321-321,共1页Tan-zhen XU Ya-li CHEN Xiao-yan SHEN Ling-Ling SUN Bi-qiong ZHANG Da-ke HUANG Wei-zu LI; supported by National Natural Science Foundation of China(81671384;81371329); OBJECTIVE To explore the protective effects and mechanisms of Ginsenoside Rg1(Rg1) on H_2O_2-induced hippocampal neurons aging in vitro.METHODS The primary culture hippo.campal neurons(7 d) were randomly placed into s...; 关键词：人参皂甙海马神经体治疗方法临床分析

Dihydroquercetin ameliorates alcoholic liver steatosis through P2x7R-NLRP3 inflammasome pathway: 《中国药理学与毒理学杂志》2018年第4期338-339,共2页Yu ZHANG Xia LI Kai-li XIA Min JIANG Ben-wen CUI Yan-ling WU Ji-xing NAN Li-hua LIAN; supported by National Natural Science Foundation of China(81560597;81260664;81360658;and 81660689); OBJECTIVE Dihydroquercetin(TAX) is the most abundant dihydroflavone found in on.ions,milk thistle and Douglas fir bark.We investigated whether TAX could inhibit the lipid accumulation in alcoholic liver steatosis in v...; 关键词：二氢黄酮酒精肝治疗方法化合物

Gentiopicroside ameliorates LKB1/AMPK-dependent alcoholic hepatosteatosis via P2x7R-NLRP3 inflammasome被引量：3: 《中国药理学与毒理学杂志》2018年第4期265-266,共2页Xia LI Yu ZHANG Kai-li XIA Min JIANG Ben-wen CUI Yan-ling WU Ji-xing NAN Li-hua LIAN; supported by National Natural Science Foundation of China(81560597;81260664;81360658;81660689); OBJECTIVE Regulating P2x7R-NLRP3 inflammasome activation might be a potential therapeutic strategy to treat alcoholic hepatosteatosis.We investigated whether this process would be modulated by gentiopicroside(GPS),whi...; 关键词：炎症酒精肝治疗方法临床分析

GSK-3β inhibition induces cardioprotection via attenuating activation of NLRP3 inflammasome after acute myocardial infarction in rats: 《中国药理学与毒理学杂志》2018年第4期270-270,共1页Shu-hui WANG Li-na XU Cheng CHANG Yu YAO Sheng-na HAN LI-rong ZHANG; supported by National Natural Science Foundation of China(8167020905); OBJECTIVE To observe the effects of glycogen synthase 3β(GSK-3β) in the regula.tion of NLRP3 inflammasome activation after acute myocardial infarction(MI) in Sprague Dawley(SD)rats.METHODS Ligation of the left anter...; 关键词：急性心肌梗塞合成酶治疗方法临床分析

Protective action of aspirin and its against endothelial Nlrp3 inflammasome activation in response to LPS stimuli: 《中国药理学与毒理学杂志》2017年第10期984-984,共1页Xing ZHOU Yi-lin ZHONG Yan-jiao WU Yi HUANG Yang CHEN; supported by National Natural Science Foundation of China(81603587,81603668);Science and Technology Development Plan of Guangdong Province(2017A020211016);Youth Medical Talent Fund of Guangzhou University of Chinese Medicine(QNYC20170105); OBJECTIVE Recent studies have demonstrated that the Nlrp3 inflammasome serve as a central role in the pathogenesis of cardiovascular diseases and endothelial dysfunction occurs in association with several cardiovascul...; 关键词：Asporin Nlrp3 inflammasome CAECs ROS

A novel mechanism underlying the protective effect of PDE4 inhibitor against cognitive impairment:inhibiting neuroinflammation through inducing autophagy in microglial cells: 《中国药理学与毒理学杂志》2017年第5期461-461,共1页YOU Ting-ting GUO Hai-biao WANG Hai-tao 徐江平; The project supported by National Natural Science Foundation of China(81373384); OBJECTIVE Inhibition of phosphodiesterase 4(PDE4) improves the learning and memory abilities in Alzheimer disease animal models. The cognition-enhancing effects of PDE4 inhibition involve reduced inflammatory response...; 关键词：phosphodiesterase 4 AUTOPHAGY INFLAMMASOME MICROGLIA

The GSK3b sensing metabolism controls NLRP3 inflammasome activation: 《中国药理学与毒理学杂志》2016年第10期1038-1039,共2页HAN Sheng-na ZHANG Li-rong Wajahat Z MEHAL OUYANG Xin-shou; OBJECTIVE To identify the role of GSK3 isoform inhibition on inflammasome activation.METHODS The NLRP3 inflammasome was activated by typical LPS/ATP and host-derived metabolites in primary mouse macrophages.The pharma...; 关键词：GSK3-β NLRP3 inflammasome IL-1β secretion O-Glc NAc transferase GLYCOSYLATION

INFLAMMASOME