PRODRUG

作品数：209被引量：333H指数：7
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相关机构：北京大学上海大学信息技术有限公司郑州大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖北省自然科学基金更多>>
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Multitarget Thiol-Activated Tetrapyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer Therapy
《CCS Chemistry》2024年第3期783-797,共15页Xue-Quan Zhou Selda Abyar Imma Carbo-Bague Lan Wang Sebastian Türck Maxime ASiegler Uttara Basu Ingo Ott Rongfang Liu Adriaan PIJzerman Sylvestre Bonnet 
the China Scholarship Council for a personal financial grant(no.201606200045);supported by the European Research Council via a Starting Grant;Dutch Research Council(NWO)for a VICI grant to S.Bonnet.
Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase(TrxR)inhibition,which disturbs the redox balance of cancer cells.However,in this model,the role of the liga...
关键词：anticancer Au(Ⅲ)complexes enzyme inhibtion potassium channel affinity lysosome damage cell imaging PRODRUG 
Tumor-Selective Cascade-Amplified Dual-Prodrugs Activation for Synergistic Oxidation-Chemotherapy
《CCS Chemistry》2022年第12期3878-3888,共11页Xuan Xiao Qingyu Zong Jisi Li Youyong Yuan 
This work was supported by the National Natural Science Foundation of China(nos.52073101 and 51873072);the Science and Technology Program of Guangzhou(no.202102010025);Guangdong Provincial Pearl River Talents Program(no.2019QN01Y088);the Special Fund for the Construction of High-level Key Clinical Specialty(Medical Imaging)in Guangzhou,Guangzhou Key Laboratory of Molecular Imaging and Clinical Translational Medicine.
Efficacy of prodrugs in cancer therapy requires selective and efficient drug activation in cancer cells.Here,we report a novel dual-prodrug delivery system with tumor-selective cascade-amplified prodrug activation for...
关键词：PRODRUG cascade drug activation oxidation-chemotherapy cancer therapy drug delivery 
A Reactive Oxygen Species-Tyrosinase Cascade-Activated Prodrug for Selectively Suppressing Melanoma
《CCS Chemistry》2022年第5期1654-1670,共17页Guorui Li Yi Yang Yaya Zhang Peiling Huang Jiangyu Yan Zhibin Song Quan Yuan Jing Huang 
funded by the National Natural Science Foundation of China(nos.31871365 and 21708007);the Technology Innovation Program of Hunan Province(no.2018RS3060).
“Off-target effect”is one of the obstacles for targeted prodrugs in chemotherapy.To circumvent this issue,herein we propose a dual biomarker cascadeactivated prodrug strategy based on high levels of reactive oxygen ...
关键词：PRODRUG cascade activated ROS TYR MELANOMA mitochondria redox homeostasis THERANOSTICS 
Esterase-Activated Theranostic Prodrug for Dual Organelles-Targeted Imaging and Synergetic Chemo-Photodynamic Cancer Therapy被引量：2
《CCS Chemistry》2022年第3期1028-1043,共16页Jiabao Zhuang Nan Li Yaling Zhang Baolin Li Hanqi Wen Xinchan Zhang Tianyu Zhang Na Zhao Ben Zhong Tang 
supported by National Natural Science Foundation of China(nos.21975149,22077077 and 21672135);Funded Projects for the Academic Leaders and Academic Backbones,Shaanxi Normal University(no.18QNGG007);the Fundamental Research Funds for the Central Universities(nos.GK201902006 and GK202003036).
Activatable prodrugs have received considerable attention in cancer therapy due to their high specificity and reduced side effects.However,the theranostic prodrug with multiple cancerous organelles targeting and combi...
关键词：aggregation-induced emission ESTERASE LYSOSOME MITOCHONDRIA photodynamic therapy chemotherapy 
A ROS-Stimulus-Responsive Nanocarrier Loading with Guanidine-Modified Hydroxycamptothecin Prodrug for Enhanced Anti-Tumor Efficacy被引量：2
《CCS Chemistry》2020年第5期305-316,共12页Zhilin Liu Haiyang Yu Na Shen Zhaohui Tang Xuesi Chen 
support for this work was provided by the Ministry of Science and Technology of China(no.2018ZX09711003-012);National Natural Science Foundation of China(Project nos.51503202,51673189,51873206,51833010,and 51520105004).
We report a reactive oxygen species(ROS)-stimulus-responsive phenylboronic acid pinacol ester nanocarrier,loaded with guanidine-modified 10-hydroxycamptothecin(HCPT)prodrug,to create a drug delivery-base nanomedicine....
关键词：ROS NANOMEDICINE cancer therapy PRODRUG NANOCARRIER 
Hydrogen Sulfide-Specific and NIR-Light-Controllable Synergistic Activation of Fluorescent Theranostic Prodrugs for Imaging-Guided Chemo- Photothermal Cancer Therapy被引量：1
《CCS Chemistry》2020年第4期527-538,共12页Ge Xu Wei Guo Xianfeng Gu Zhijun Wang Rongchen Wang Tianli Zhu He Tian Chunchang Zhao 
support by the National Natural Science Foundation of China(21672062,21874043,21572039,and 21788102);Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX03);the Program of Introducing Talents of Discipline to Universities(B16017).
Theranostic prodrugs are promising for cancer medicine;however,the inability to activate these systems exclusively at the desired tumor location compromises the specificity and efficacy of cancer treatment.Here,we dev...
关键词：THERANOSTIC PRODRUG hydrogen sulfide NIR fluorescence light-controllable cancer therapy 
Bioorthogonal Prodrug–Antibody Conjugates for On-Target and On-Demand Chemotherapy被引量：4
《CCS Chemistry》2019年第2期226-236,共11页Feng Lin Long Chen Heng Zhang William Shu Ching Ngai Xiangmei Zeng Jian Lin Peng R.Chen 
Current antibody–drug conjugates(ADCs)suffer from low tissue penetration and significant side effects,largely due to the permanent linkage and/or premature release of cytotoxic payloads.Herein,we developed a prodrug...
关键词：antibody-drug conjugates bioortho-gonal prodrug iEDDA reaction enhanced tumor penetration alleviated side effects 
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