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作品数：561被引量：1898H指数：18
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The crosstalk between non-coding RNAs and oxidative stress in cancer progression
《Genes & Diseases》2025年第3期146-167,共22页Qiqi Sun Xiaoyong Lei Xiaoyan Yang 
funded by the Hengyang City Science and Technology Planning Project(Hunan,China)(No.202150063473);the Scientific Research Project of Hunan Provincial Health Commission(China)(No.202202044140);the Scientific Research Project of Hunan Provincial Education Department(China)(No.21B0438).
As living standards elevate,cancers are appearing in growing numbers among younger individuals globally and these risks escalate with advancing years.One of the reasons is that instability in the cancer genome reduces...
关键词：ANGIOGENESIS Autophagy CANCER Cancer energy metabolism Epithelial mesenchymal transformation Non-coding RNAs Oxidative stress 
Dynamics of epithelial-mesenchymal plasticity driving cancer drug resistance
《Cancer Pathogenesis and Therapy》2025年第2期120-128,共9页Rashmi Bangarh Reena V.Saini Adesh K.Saini Tejveer Singh Hemant Joshi Seema Ramniwas Moyad Shahwan Hardeep Singh Tuli 
supported by the DST-INSPIRE(Department of Science&Technology-Innovation in Science Pursuit for Inspired Research)Fellowship(No.IF210078);the Department of Science and Technology(Technology Development Program),Government of India(No.TDP/BDTD/54/2021/General);the Indian Council of Medical Research-Department of Health Research(ICMR-DHR)Young Scientist Fellowship(F.No:R.12014/29/2022/HR).
Epithelial-mesenchymal transition(EMT)promotes several cancers by increasing tumor cell motility,disrupting epithelial cell phenotypes,apical-basal polarity,and intracellular connections,and enhancing tumor resistance...
关键词：Epithelial-mesenchymal transition Tumor microenvironment METASTASIS Cancer drug resistance 
Anticancer effects of SH003 and its active component Cucurbitacin D on oral cancer cell lines via modulation of EMT and cell viability
《Oncology Research》2025年第5期1217-1227,共11页HYEONG SIM CHOI JEONG-KUI KU SEONG-GYU KO PIL-YOUNG YUN 
supported by grants from the Seoul National University Bundang Hospital(SNUBH)Research Fund(Grant no.02-2020-0008);the Creative-Pioneering Researchers Program of Seoul National University(Grant no.860-20240109).
Background:Oral cancer remains a significant global health challenge,as it has high morbidity and mortality rates.Current treatments show limited efficacy and have severe side effects,prompting searches for new therap...
关键词：SH003 Oral cancer Cucurbitacin D Epithelial–mesenchymal transition(EMT) MIGRATION 
Melatonin Mitigates Atrazine-Induced Renal Tubular Epithelial Cell Senescence by Promoting Parkin-Mediated Mitophagy
《Research》2025年第1期135-148,共14页Yu-Sheng Shi Tian-Ning Yang Yu-Xiang Wang Xiang-Yu Ma Shuo Liu Yi Zhao Jin-Long Li 
supported by the National Natural Science Foundation of China(no.32172932);Key Program of Natural Science Foundation of Heilongjiang Province of China(no.ZD2021C003);China Agriculture Research System of MOF and MARA(no.CARS-35);Distinguished Professor of Longjiang Scholars Support Project(no.T201908),Heilongjiang Touyan Innovation Team Program.
The accumulation of senescent cells in kidneys is considered to contribute to age-related diseases and organismal aging.Mitochondria are considered a regulator of cell senescence process.Atrazine as a triazine herbici...
关键词：mitochondrial homeostasis cell senescence processatrazine triazine herbicide parkin mediated mitophagy senescent cells ATRAZINE renal tubular epithelial cell senescence MELATONIN 
EMP2 promotes hepatocellular carcinoma proliferation and invasion by activating cellular autophagy
《Oncology Research》2025年第2期443-464,共22页HAIYING PANG FENGBO WU YU ZHANG NAN ZHANG CHUNTING WANG QIU LI GU HE PENG ZHANG 
supported by the Fundamental Research Funds for the National Natural Science Foundation of China(Nos.22177084 and 82104373);the Fundamental Research Funds of Science&Technology Department of Sichuan Province(No.2022YFQ0054).
Background:EMP2 is a tumor-associated membrane protein belonging to the GAS-3/PMP22 gene family.EMP2 expression demonstrates significant tissue specificity and heterogeneity in various human tissues and tumor tissues,...
关键词：Epithelial membrane protein 2 Hepatocellular carcinoma AUTOPHAGY Integrin pathway 
Natural product mediated mesenchymaleepithelial remodeling by covalently binding ENO1 to degrade m6A modified b-catenin mRNA
《Acta Pharmaceutica Sinica B》2025年第1期467-483,共17页Tianyang Chen Guangju Liu Sisi Chen Fengyuan Zhang Shuoqian Ma Yongping Bai Quan Zhang Yahui Ding 
support of the National Natural Science Foundation of China(Nos.81872764 and 82273808 to Quan Zhang and No.82272654 to Yahui Ding).
The transition of cancer cells from epithelial state to mesenchymal state awarded hepatocellular carcinoma(HCC)stem cell properties and induced tumorigenicity,drug resistance,and high recurrence rate.Reversing the mes...
关键词：Natural product Target identification ENO1 Mesenchymal-epithelial remodeling Β-CATENIN 
Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis
《International Journal of Oral Science》2024年第4期743-758,共16页Mouyuan Sun Ning Zhan Zhan Yang Xiaoting Zhang Jingyu Zhang Lianjie Peng Yaxian Luo Lining Lin Yiting Lou Dongqi You Tao Qiu Zhichao Liu Qianting Wang Yu Liu Ping Sun Mengfei Yu Huiming Wang 
financially supported by the following programs:National Natural Science Foundation of China(82122014,82071085,82001045,82201122,82020108011);National Key Research and Development Program of China(2018YFA0703000);China Postdoctoral Science Foundation(2023M743009);Zhejiang Provincial Natural Science Foundation of China(LR21H140001,LQ21H140002,LR22H140005);Zhejiang Basic Public Welfare Research Project(LGF22H140007);Medical Technology and Education of Zhejiang Province of China(2018KY501);Foundation of Zhejiang University(2022QZJH55);Zhejiang University of Stomatology Postdoctoral Scientific Research Foundation(2023PDF013);Foundation of Stomatology Hospital Affiliated to Zhejiang University School of Medicine(RD2022JCXK01)。
The development,progression,and curative efficacy of head and neck squamous cell carcinoma(HNSCC)are influenced by complex interactions between epithelial and immune cells.Nevertheless,the specific changes in the natu...
关键词：MALIGNANT SQUAMOUS INVASION 
The Effect of Optimized Intense Pulsed Light Therapy on Meibomian Gland Function and Corneal Epithelial Healing for Patients with Blepharitis-associated Dry Eye Disease
《Chinese Journal of Biomedical Engineering(English Edition)》2024年第4期146-152,共7页CHEN Jing-ling ZENG Cha-lian 
Objective:To develop and optimize intense pulsed light(IPL)technology for the treatment of blepharitis-associated dry eye disease and to evaluate its biomedical effects on meibomian gland function and corneal epitheli...
关键词：intense pulse light(IPL)technology blepharitis-associated dry eye disease meibomian gland function corneal epithelial repair 
Western diet induces GSDME-mediated epithelial pyroptosis through the DCA-S1PR2 pathway to disrupt the intestinal epithelial barrier被引量：1
《Science Bulletin》2024年第24期3832-3837,共6页Ke Liu Mengyao Song Xueqin Huang Yanqiang Shi Sheng Li Fangqing Zhu Teng Ben Xinlong Lin Bingxia Chen Beibei Xu Sicong Ma Binhai Shen Zheng Chen Xinwen Yan Ruo Huang Fachao Zhi Gao Tan 
supported by the National Natural Science Foundation of China(81970492 and 82270547);Outstanding Youths Development Scheme of Nanfang Hospital,Southern Medical University(2021J009).
Inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic and refractory inflammatory bowel disorder[1].The incidence of IBD is greater in Western countries than in Asia and...
关键词：MIDDLE barrier BOWEL 
Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehydrodiisoeugenol
《Acta Pharmaceutica Sinica B》2024年第12期5286-5304,共19页Ruiyang Gao Bei Yue Cheng Lv Xiaolong Geng Zhilun Yu Hao Wang Beibei Zhang Fangbin Ai Ziyi Wang Donghui Liu Zhengtao Wang Kaixian Chen Wei Dou 
supported by the National Natural Science Foundation of China(No.82274329,82304991,82130115);the China Postdoctoral Science Foundation(No.2023M732336);the Shanghai Science and Technology Committee Sailing Program Foundation(No.23YF1442500,China).
Irinotecan(CPT11)chemotherapy-induced diarrhea affects a substantial cancer population due to b-glucuronidase(Gus)converting 10-O-glucuronyl-7-ethyl-10-hydroxycamptothecin(SN38G)to toxic 7-ethyl-10-hydroxycamptothecin...
关键词：IRINOTECAN Intestinal mucositis b-Glucuronidase Enterococcus faecalis Intestinal stem cells Epithelial regeneration Gus bacteriaehost eirinotecan axis Dehydrodiisoeugenol 
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