ANTIVIRAL

作品数：505被引量：1623H指数：17
导出分析报告
相关领域：医药卫生更多>>
相关作者：张秀春王健李红黄岳顺陈润生更多>>
相关机构：中国科学院北京地坛医院中国农业大学苏州大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 期刊=Cell Researchx
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
AHI1: linking depression and impaired antiviral immune response
《Cell Research》2022年第10期869-870,共2页Weili Yang Shihua Li Xiao-Jiang Li 
AHI1 is a neurodevelopmental gene,and its expression deficiency was found to correlate with altered stress responses and depressive behaviors in mice.In a recent paper of Cell Research,Zhang et al.show that AHI1 reduc...
关键词：AHI IMPAIRED immunity 
Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis被引量：5
《Cell Research》2022年第10期897-913,共17页Hong-Guang Zhang Bin Wang Yong Yang Xuan Liu Junjie Wang Ning Xin Shifeng Li Ying Miao Qiuyu Wu Tingting Guo Yukang Yuan Yibo Zuo Xiangjie Chen Tengfei Ren Chunsheng Dong Jun Wang Hang Ruan Miao Sun Xingshun Xu Hui Zheng 
supported by grants from the National Key R&D Program of China(2017YFE0103700,2018YFC1705500 and 2018YFC1705505);the National Natural Science Foundation of China(31770177,31970846,81120108011,81771454,and 82071511);Jiangsu Provincial Distinguished Young Scholars(BK20130004);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
Depression is a serious public-health issue.Recent reports have suggested higher susceptibility to viral infections in depressive patients.However,how depression affects antiviral innate immune signaling remains unkno...
关键词：AHI IMMUNITY INTERFERON 
Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2被引量：12
《Cell Research》2022年第1期9-23,共15页Shaojun Zhang Wenze Huang Lili Ren Xiaohui Ju Mingli Gong Jian Rao Lei Sun Pan Li Qiang Ding Jianwei Wang Qiangfeng Cliff Zhang 
supported by the National Natural Science Foundation of China(91740204,91940306,and 31761163007 to Q.C.Z.,81930063 to J.W.,32070153 to Q.D.);the National Key R&D Program of China(2018YFA0107603 and 2019YFA011000 to Q.C.Z.);Tsinghua University Spring Breeze Fund(2020Z99CFY029 to Q.C.Z.,2021Z99CFY030 to Q.D.);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020HY320001 to L.R.);the Tsinghua-Cambridge Joint Research Initiative Fund(2019Z02CAU to Q.C.Z.).
In contrast to the extensive research about viral protein–host protein interactions that has revealed major insights about how RNA viruses engage with host cells during infection,few studies have examined interaction...
关键词：DRUGS VIRAL INTERACT 
ERASE:a novel nucleic-acid based antiviral mechanism
《Cell Research》2021年第11期1142-1143,共2页George Fu Gao 
Nucleic acid-based antiviral systems,including CRISPR/Cas and RNA interference,play important roles in antiviral defense.In a paper recently published in Cell Research,Wu et al.revealed a novel nucleic acid-based anti...
关键词：CRISPR/Cas mechanism. al. 
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells
《Cell Research》2021年第9期998-1010,共13页Junyu Wu Chunyan Wu Fan Xing Liu Cao Weijie Zeng Liping Guo Ping Li Yongheng Zhong Hualian Jiang Manhui Luo Guang Shi Lang Bu Yanxi Ji Panpan Hou Hong Peng Junjiu Huang Chunmei Li Deyin Guo 
The work is supported by the National Natural Science Foundation of China(81620108020 and 32041002 to D.G.,31800151 to J.W.,81803568 to FX);Guangdong Zhujiang Talents Program(to D.G.);Shenzhen Science and Technology Program(KQTD20180411143323605 and JSGG20200225150431472 to D.G.,JCYJ20170818162249554 to F,X.);National Ten-thousand Talents Program(to D.G.)。
Nucleic acid-based systems play important roles in antiviral defense,including CRISPR/Cas that adopts RNA-guided DNA cleavage to prevent DNA phage infection and RNA interference(RNAi)that employs RNA-guided RNA cleava...
关键词：ENDOGENOUS CLEAVAGE destroyed 
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target被引量：13
《Cell Research》2021年第8期847-860,共14页Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao 
Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E...
关键词：DISTRESS ACUTE RESPIRATORY 
Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation被引量：8
《Cell Research》2019年第8期641-654,共14页Yumei Zhou Mengxuan Li Yiquan Xue Zhiqing Li Weitao Wen Xingguang Liu Yuanwu Ma Lianfeng Zhang Zhongyang Shen Xuetao Cao 
We thank Dr. Pin Wang for technical assistance. supported by grants from the National Natural Science Foundation of China (81788101 to X.C.);the National Key Research & Development Program of China (2018YFA0507403 to X.C.);CAMS Innovation Fund for Medical Sciences (2016-12M-1-003 to X.C.).
Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate immune response to viral infection. How this response can be enhanced, however, remains to be explored. Here, we identify a new cyt...
关键词：production POTENT pathway 
Antiviral immunity: a link to bile acids
《Cell Research》2019年第3期177-178,共2页Jing Wang Richard A. Flavell Hua-Bing Li 
National Natural Science Foundation of China (91753141 to HBL).
A recent study in Cell Research by Hu et al. describes a novel function of intracellular bile acids (BAs), a class of cholesterolderived metabolites, which activate several key innate antiviral signaling components th...
关键词：ANTIVIRAL IMMUNITY BILE ACIDS 
Siglecl suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27被引量：26
《Cell Research》2015年第10期1121-1136,共16页Qingliang Zheng Jin Hou Ye Zhou Yingyun Yang Bing Xie Xuetao Cao 
Type I interferon （IFN） production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations o...
关键词：Siglec 1 innate immune response type I interferon TBK1 TRIM27 
IFNβ/TNFa synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response被引量：3
《Cell Research》2013年第5期673-690,共18页Karin Fink Lvdie Martin Esperance Mukawera St&any Chartier Xavier De Deken Emmanuelle Brochiero Francoise Mi Nathalie Grandvaux 
Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and proinflammatory cytokines that act in an autocrine/paracrine fash...
关键词：ANTIVIRAL cell signaling innate immunity inflammation NADPH oxidase INTERFERON 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部