LYMPHOTOXIN

作品数：9被引量：10H指数：2
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相关领域：医药卫生更多>>
相关作者：刘梦蕾更多>>
相关机构：第二军医大学更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》《Cellular & Molecular Immunology》《Journal of Biomedical Research》更多>>
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Role of lymphotoxin alpha as a new molecular biomarker in revolutionizing tear diagnostic testing for dry eye disease
《International Journal of Ophthalmology(English edition)》2023年第11期1883-1889,共7页Chao-Ran Li 
Dry eye disease(DED),primarily classified as multifactorial ocular surface disorder,afflicts tens of millions of individuals worldwide,adversely impacting their quality of life.Extensive research has been conducted on...
关键词：dry eye disease tear film BIOMARKER matrix metalloproteinase 9 lymphotoxin alpha 
Effect of lymphotoxin blockage on different stages of Sjogren's syndrome in an animal model
《Rheumatology & Autoimmunity》2022年第2期76-81,共6页Alexander Jacob Long Shen Jing He Kelly Nealon Jessy J.Alexander Julian L.Ambrus Jr 
Background:Lymphotoxin(LT)is an important mediator in Sjogren's syndrome(SS),both in patients and in animal models.Deletion of the LT alpha gene prevented the development of disease manifestations in the interelukin a...
关键词：animal model LYMPHOTOXIN Sjogren's syndrome 
Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation被引量：3
《Cellular & Molecular Immunology》2018年第7期697-709,共13页Yuan Zhang Tae-Jin Kim Joanna A Wroblewska Vera Tesic Vaibhav Upadhyay Ralph R Weichselbaum Alexei V Tumanov Hong Tang Xiaohuan Guo Haidong Tang Yang-Xin Fu 
Splenomegaly is a well-known phenomenon typically associated with inflammation.However,the underlying cause of this phenotype has not been well characterized.Furthermore,the splenomegaly phenotype seen in lymphotoxin(...
关键词：GERM-FREE LYMPHOTOXIN MICROBIOTA SPLENOMEGALY type 3 innate lymphoid cells 
Pathological significance and regulatory mechanism of lymphotoxin β receptor overexpression in T cells of patients with systemic lupus erythematosus被引量：1
《The Journal of Biomedical Research》2018年第2期113-122,共10页Cheng Yin Xubing Cai Huijuan Wang Bingjie Gu Xiaofan Yang Rong Zhang Xiaohui Ji 
Systemic lupus erythematosus（SLE） is a typical autoimmune disease. Lymphotoxin β receptor（LTβR） signaling plays an important role in autoimmune inflammations. LTβR-Ig fusion protein, LTβR blocking agent, has b...
关键词：lupus erythematosus systemic（SLE） lymphotoxin β receptor（LTβR） interleukin-17（IL-17） interleukin-23 receptor（IL-23R） 
Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy被引量：6
《Cellular & Molecular Immunology》2017年第10期809-818,共10页Haidong Tang Mingzhao Zhu Jian Qiao Yang-Xin Fu 
by the US National Institutes of Health through National Cancer Institute grants CA141975 and CA97296,CPRIT grant RR150072,grants from the Chinese Academy of Sciences(XDA09030303);grants from the Chinese Ministry of Science and Technology(2012ZX10002006,2011DFA31250 and 2012AA020701)to YXF and a Cancer Resarch Institute Irvington Fellowship to HT.
Tertiary lymphoid structures(TLS)often develop at sites of persistent inflammation,including cancers and autoimmune diseases.In most cases,the presence of TLS correlates with active immune responses.Because of their p...
关键词：autoimmune disease CANCER IMMUNOTHERAPY lymphotoxin signalling tertiary lymphoid structure 
No Association of Lymphotoxin a AspH1 Genotype and Tumor Necrosis Factor-238 Genotype with Genetic Susceptibility in Chinese Patients with Ulcerative Colitis
《胃肠病学》2000年第B08期100-100,共1页XiaB ZhangGS DingGP ZhouY DengCS 
关键词：淋巴毒素 基因型 肿瘤坏死因子-238 遗传性 感染性 溃疡性淋巴管炎 
DISTRIBUTION OF AN NcoI POLYMORPHISM IN THE LYMPHOTOXIN α GENE IN DUTCH PATIENTS WITH INFLAMATORY BOWEL DISEASES
《Chinese Medical Journal》1995年第10期739-742,共4页夏冰 G Bouma JBA Grusius SGM Meuwissen AS Pena 
An Ncol restriction fragment length polymorphism in the first intron of the lymphotoxin α gene was investigated in 35 patients with Crohn's disease, 40 patients with ulcerative colitis, and 30 unrelated healthy contr...
关键词：IBD GENE DISTRIBUTION OF AN NcoI POLYMORPHISM IN THE LYMPHOTOXIN GENE IN DUTCH PATIENTS WITH INFLAMATORY BOWEL DISEASES MHC UC 
Identification of an ｋB-like motif at the 5' upstream region of human lymphotoxin gene
《Cell Research》1994年第1期1-7,共7页XURENER SHOUYUANZHAO 
Lymphotoxin(LT) is a glycoprotein secreted by activated T cell. The expression of LT gene is mainly regulated at the level of transcription. By using human LT DNA as a probe, we carried out a RNA dot blotting test and...
关键词：human LT gene protein-DNA interaction transcription regulation 
THE ANTITUMOR ACTIVITY OF LYMPHOTOXIN AND THE EFFECT OF INTERLEUKIN-2 ON ITS FUNCTION
《Chinese Journal of Cancer Research》1990年第4期45-49,共5页沈泽荔 何俊森 
The effect of lymphotoxin (LT)-containing supernatant produced by lectin-stimulated human lymphocytes on tumor cells and the relation between interleukin-2 (IL-2) and LT were studied in this article. Results showed th...
关键词：THE ANTITUMOR ACTIVITY OF LYMPHOTOXIN AND THE EFFECT OF INTERLEUKIN-2 ON ITS FUNCTION MTT 
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