Α-GAL

作品数:44被引量:63H指数:4
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相关领域:医药卫生生物学更多>>
相关作者:郑毅李胜富李幼平李文歌刘革力更多>>
相关机构:重庆医科大学山东大学中国科学院中日友好医院更多>>
相关期刊:《International Journal of Ophthalmology(English edition)》《中国肺癌杂志》《Chinese Medical Journal》《中国肿瘤生物治疗杂志》更多>>
相关基金:国家自然科学基金国家高技术研究发展计划国家重点基础研究发展计划山东省科技发展计划项目更多>>
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α-Galactosylceramide modulates the brain's inflammatory microenvironment to counteract learning and memory dysfunction in Aβ_(1–42)model mice
《Journal of Chinese Pharmaceutical Sciences》2024年第12期1110-1117,共8页Guangchan Jing Jingting Kang Chao Ji 
National Natural Science Foundation of China(Grant No.81100801)。
Alzheimer's disease(AD)is the most prevalent neurodegenerative disorder affecting the elderly.Among its pathological mechanisms,neuroinflammation triggered by amyloid-β(Aβ)aggregation is considered a key contributor...
关键词:Alzheimer’s disease Α-GALCER M2 microglia/macrophage NEUROINFLAMMATION Microglial polarization 
A comparative study of human and porcine-derived decellularised nerve matrices被引量:1
《Biomaterials Translational》2023年第3期180-195,共16页Rui Li Shuai Qiu Weihong Yang Zilong Rao Jiaxin Chen Yuexiong Yang Qingtang Zhu Xiaolin Liu Ying Bai Daping Quan 
the National Natural Science Foundation of China(Nos.51903255 and 52073314);The Key Areas Research and Development Program of Guangdong Province(No.2020B1111150003);Science and Technology Program of Guangzhou City(No.201904010364).
Decellularised extracellular matrix(dECM)biomaterials originating from allogeneic and xenogeneic tissues have been broadly studied in the field of regenerative medicine and have already been used in clinical treatment...
关键词:ALLOGENEIC decellularised nerve matrix immune response xenogeneic Α-GAL 
Evaluatingα-galactosylceramide as an adjuvant for live attenuated infuenza vaccines in pigs
《Animal Diseases》2022年第4期231-245,共15页Bianca L.Artiaga Igor Morozov Russell Ransburgh Taeyong Kwon Velmurugan Balaraman Sabarish V.Indran Darling Melany De Carvalho Madrid Weihong Gu Jamie Henningson Wenjun Ma Jürgen A.Richt John P.Driver 
funded by the National Institutes of Health grant number HD092286(JPD and JAR);the U.S.Department of Agriculture grant number 2016-09448(JPD);the AMP Core of the Center of Emerging and Zoonotic Infectious Diseases(CEZID)from National Institute of General Medical Sciences(NIGMS)under award number P20GM130448;the NIAID supported Centers of Excellence for Infuenza Research and Response(CEIRR,contract number 75N93021C00016;the NIAID funded Center of Excellence for Infuenza Research and Surveillance(CEIRS)grant number HHSN272201400006C(JAR);the U.S.Department of Homeland Security grant number DHS2010-ST-061-AG0001(JAR);the Center of Excellence for Emerging and Zoonotic Animal Disease(CEEZAD).
Natural killer T(NKT)cells activated with the glycolipid ligandα-galactosylceramide(α-GalCer)stimulate a wide variety of immune cells that enhance vaccine-mediated immune responses.Several studies have used this app...
关键词:Natural killer T cell Infuenza A virus Vaccine Live attenuated infuenza virus ADJUVANT α-Galactosylceramide SWINE 
Author Correction:α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice
《Acta Pharmacologica Sinica》2022年第7期1875-1878,共4页Xin Chen Jie Liu Jie Liu Wen-jia Wang Wen-jing Lai Shu-hui Li Ya-fei Deng Jian-zhi Zhou Sheng-qian Yang Ying Liu Wei-nian Shou Da-yan Cao Xiao-hui Li 
During our recent check of our published article entitled“α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice”published in Acta Pharmacologica Sinica...
关键词:PATHOGENESIS cardiac injury 
对动物源性医疗器械免疫毒理学评价的思考被引量:2
《中国医疗器械信息》2021年第3期1-3,9,共4页翁旭 奚晓青 陆佳骏 黄仁良 赵金川 
浙江省省属科研院所扶持经费项目(项目编号:304017-2018-1043);浙江省医疗器械检验研究院自立项项目(项目名称:动物源性医疗器械对机体自然杀伤细胞的影响,项目编号:20180002)。
阐述了对于动物源性医疗器械免疫毒理学评价的思考。主要介绍了动物源性医疗器械的种类以及关于动物源性医疗器械的国内外法规,同时详细介绍分析了动物源性医疗器械免疫毒理学评价的具体检测方法,同时对动物源性医疗器械免疫学评价进行...
关键词:动物源性医疗器械 免疫毒理 DNA残留量 α-Gal抗原残留 
α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice
《Acta Pharmacologica Sinica》2020年第11期1416-1426,共11页Xin Chen Jie Liu Jie Liu Wen-jia Wang Wen-jing Lai Shu-hui Li Ya-fei Deng Jian-zhi Zhou Sheng-qian Yang Ying Liu Wei-nian Shou Da-yan Cao Xiao-hui Li 
This study was funded by the National Natural Science Foundation of China(#81773742 and #81520108029 to XHL,#81703521 to YFD,and #81473260 to JZZ).
Immunotherapies for can cers may cause severe and life-threate ning cardiotoxicities.The underlyi ng mecha nisms are complex and largely elusive.Currently,there are several on going clinical trials based on the use of...
关键词:α-galactosylceramide OCH iNKT cells isoprote renol can cer immunotherapy CARDIOTOXICITY on cocardiology 
JACI:恙螨叮咬会导致对红肉过敏?
《健康大视野》2018年第17期13-13,共1页
恙螨是一类令人讨厌的小虫子,它们通常在脚踝和腰围附近的咬伤会引起发痒的皮疹。根据Wake Forest Baptist医学中心的医生的说法,除了感到不舒服和烦恼外,这些叮咬还可能对被称为α-gal的红肉产生相对罕见的过敏反应。
关键词:过敏反应 红肉 叮咬 恙螨 Α-GAL 医学中心 
激光微孔化脱细胞骨软骨支架的制备及表征
《中国组织工程研究》2018年第18期2836-2842,共7页刘雪剑 刘士臣 孙百川 张凯红 孟昊业 王玉 黄绍代 鲁长风 王冲 余文 荆晓光 赵跃 杨建华 彭江 
北京市科技专项(Z161100005016059);国家自然科学基金(81572148);国家重点研发计划(2016YFC1102104);佳木斯大学科学技术重点项目(基础研究类)(12Z1201507);黑龙江省大学生创新创业训练计划项目(201610222058);黑龙江省教育厅基础研究项目(2016-KYYWF-0548)
背景:如何制备出既具有软骨源性成分又具有良好初始力学强度的支架,是组织工程软骨研究的方向。目的:制备微孔化脱细胞骨软骨支架,评价其力学性能及细胞相容性。方法:取猪膝关节骨软骨,采用激光微孔化技术制作微孔化骨软骨支架,随后利...
关键词:软骨组织工程 脱细胞 骨软骨支架 共培养 骨髓间充质干细胞 激光微孔化 α-Gal抗原检测 生物相容性 生物材料 
Screening of Fabry disease in patients with end-stage renal disease of unknown etiology:the first Thailand study被引量:1
《The Journal of Biomedical Research》2017年第1期17-24,共8页Objoon Trachoo Paisan Jittorntam Sarunpong Pibalyart Saowanee Kajanachumphol Norasak Suvachittanont Suthep Patputthipong Piyatida Chuengsaman Arkom Nongnuch 
We aimed to explore the prevalence of Fabry disease in Thai patients who were diagnosed with end-stage renal disease(ESRD) of an unknown origin.Venous blood samples were collected from ESRD patients for biochemical ...
关键词:Fabry disease end-stage renal disease(ESRD) Alpha-galactosidase A(α-GAL A) 
α-半乳糖神经酰胺负载DC促进CIK细胞对肝癌细胞的杀伤效应被引量:1
《中国肿瘤生物治疗杂志》2016年第2期175-181,共7页刘红彦 张颖 王晶波 陈莉 王惠 李栋 盖中涛 
山东省科技发展计划资助项目(No.2012GGA01219);济南市科技发展计划资助项目(No.201302032);济南市2012年度科技型中小企业技术创新基金资助~~
目的:研究负载α-半乳糖神经酰胺(alpha-galactosylceramide,α-Gal Cer)的DC功能与成熟度的改变情况,探讨α-Gal Cer-DC与CIK共培养对CIK细胞表型、增殖活性及杀伤肝癌细胞效率的影响。方法:采用密度梯度离心法从人外周血中分离出单个...
关键词:树突状细胞 细胞因子诱导的杀伤细胞 Α-GAL CER 肝癌 增殖 成熟 肿瘤杀伤活性 
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