support from the Miami Project to Cure Paralysis,the Buoniconti Fund,and the Interdisciplinary Stem Cell Institute(to AK,WDD,JDG,and ADL);the unconditional support of Dean Henri Ford of the Leonard M.Miller School of Medicine at the University of Miami.
Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular junction.In amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann c...
BACKGROUND Bone marrow transplantation(BMT)is a breakthrough procedure for patients with hematological and oncological conditions,particularly when all other treat-ments fail.Its indications vary between patients and ...
BACKGROUND The induced-membrane technique was initially described by Masquelet as an effective treatment for large bone defects,especially those caused by infection.Here,we report a case of chronic osteomyelitis of th...
supported by National Natural Science Foundation of China(82170214,81970159 and 82370218 to Bin Pan,81930005 and 82341203 to Kailin Xu);the Jiangsu Provincial Key Research and Development Program(BE2021631 to Bin Pan,China);the Natural Science Research of Jiangsu Higher Education Institutions of China(20KJA320002 to Bin Pan);Prof.Robert Peter Gale(Imperial College of Science,Technology and Medicine)kindly revised the typescript.
Targeting T-cell is a strategy to control allogeneic response disorders,such as acute graftversus-host disease(GVHD)which is an important cause of therapy-failure after allogeneic hematopoietic cell transplants.Free f...
supported by the Deutsche Forschungsgemeinschaft(DFG,project nr.536993790);the European Regional Development Fund(project ZELL-THEMA).
In a recent study published in Cell,Wang X et al.1 reported the first use of allogeneic anti-CD19 CAR T cells in patients with therapyresistant autoimmune diseases,demonstrating their effectiveness in reducing disease...
Objective To determine the effect of glucose-6-phosphate-dehydrogenase (G6PD) deficiency on patients'complications and prognosis following allogeneic stem cell hematopoietic transplantation (allo-HSCT).
Collecting umbilical cord stem cells is widely practiced due to its numerous benefits. Over the past decade, umbilical cord stem cells (UCSCs) have shown effectiveness in treating various conditions, such as bone path...
Alloantibodies that are non ABO Alloimmunization to protein antigens happens only after exposure, in contrast to ABO isohaemagglutinins, which are present naturally, even in the absence of prior exposure. It is recogn...
Chimeric antigen receptor(CAR)T-cell therapy has ushered in substantial advancements in the management of various B-cell malignancies.However,its integration into chronic lymphocytic leukemia(CLL)treatment has been ch...
BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and posture.Disturbances in motor functions constitute the main body of CP symptoms.These symptoms surface in early childhood and ...