云南高校图书馆联盟文献共享服务平台- NUCLEOLIN

NUCLEOLIN: 作品数：19被引量：37H指数：5; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：赵银龙宋晓良郭钰英钱成明蒙国照更多>>; 相关机构：四川大学吉林大学第二医院武汉大学上海交通大学更多>>; 相关期刊：《Genes & Diseases》《Current Medical Science》《Journal of Chinese Pharmaceutical Sciences》《中国实验诊断学》更多>>; 相关基金：国家自然科学基金国家教育部博士点基金中国博士后科学基金国家重点基础研究发展计划更多>>

A pH-Sensitive I-Motif Aptamer Probe for Dual Targeting and Imaging of Pancreatic Cancer Cells via Nucleolin Interactions: 《Journal of Bio-X Research》2024年第3期114-118,共5页Quwen Li Qingquan Chen Juan Tang Qicai Liu Feng Gao; This work was supported by the National Natural Science Foundation of China(No.82172953);the Fujian Natural Science Foundation(No.2021J01716);the National Key Clinical Specialty Construction Project Fund(No.2022YBL-ZD-02).; This study investigates the targeted imaging and tumor inhibition effects of a"signal-off"imaging-based activatable aptamer probe(I-AAP)for pancreatic cancer.AS1411,contained in the I-AAP probe,targets the nucleolin a...; 关键词：dual targeting tumor inhibition pancreatic cancer i motif aptamer phosphate buffer solution targeted imaging ph sensitive

Nucleolin promotes tumor growth in colorectal cancer by enhancing hnRNPA1-mediated PKM2 alternative splicing: 《Genes & Diseases》2023年第6期2237-2240,共4页Xue Wang Han Cheng Die Hu Ying Chen Waseem Hassan Jing Zhao Jiuming Li Zhaohui Huang; supported by the National Natural Science Foundation of China(No.81802462,81972220,and 82173063);the Natural Science Foundation of Jiangsu Province,China(No.BK20180618 and BE2019632);Wuxi Taihu Lake Talent Plan,and Wuxi Medical Key Discipline(China)(No.ZDXK2021002);China Postdoctoral Science Foundation(No.2020M681493);Postdoctoral Science Foundation of Jiangsu Province,China(No.2020Z050);Fundamental Research Funds for the Central Universities(China)(No.JUSRP11952).; Emerging evidence indicates that metabolism reprogramming plays an important role in cancer progression.RNAbinding protein nucleolin(NCL)was reported to function as an important oncogenic factor in multiple cancer typ...; 关键词：PKM2 METABOLISM MEDIATED

A tRF oligomerizes Nucleolin to stabilize metastasis-favoring transcripts: 《Science China(Life Sciences)》2023年第3期646-648,共3页Jiawei Guo Yong Peng; supported by the National Natural Science Foundation of China(82273168);the Science and Technology Foundation of Sichuan Province,China(2022YFS0046);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD20008)。; Apart from bringing amino acids to ribosomes for protein biogenesis,transfer RNA(t RNA)can be cleaved into small non-coding RNAs,named as t RFs or ts RNAs.These small RNA fragments were firstly thought as random degra...; 关键词：METASTASIS bringing

Nucleolin interacts with the rabbit hemorrhagic disease virus replicase RdRp, nonstructural proteins p16 and p23, playing a role in virus replication被引量：1: 《Virologica Sinica》2022年第1期48-59,共12页Jie Zhu Qiuhong Miao Hongyuan Guo Aoxing Tang Dandan Dong Jingyu Tang Fang Wang Guangzhi Tong Guangqing Liu; sponsored by Shanghai Sailing Program(20YF1457700);the National Natural Science Foundation of China(32000109 and 31672572);the China Postdoctoral Science Foundation(2019M660885 and 2021T140718); Rabbit hemorrhagic disease virus(RHDV)is a member of the Caliciviridae family and cannot be propagated in vitro,which has impeded the progress of investigating its replication mechanism.Construction of an RHDV replico...; 关键词：Rabbit hemorrhagic disease virus(RHDV) NUCLEOLIN Virus replication RNA-dependent RNA polymerase(RdRp)

Nucleolin Mediates LPS-induced Expression of Inflammatory Mediators and Activation of Signaling Pathways被引量：2: 《Current Medical Science》2020年第4期646-653,共8页Li FANG Kang-kai WANG Qing HUANG Feng CHENG Fang HUANG Wei-wei LIU; This work was supported by grants from Bureau of Science and Technology of Changsha,China(No.Kq 1701007);Hunan Natural Science Foundation,China(No.2018JJ6127).; Summary:In this study,we investigated the effects of nucleolin on lipopolysaccharide(LPS)-induced activation of MAPK and NF-KappaB(NF-kB)signaling pathways and secretion of TNF-a,IL-1βand HMGB1 in THP-1 monocytes.Imm...; 关键词：NUCLEOLIN THP-1 monocytes LIPOPOLYSACCHARIDE MAPK NF-κB signaling pathway inflammatory mediators

MicroRNA Profiling of Transgenic Mice with Myocardial Overexpression of Nucleolin: 《Chinese Medical Journal》2018年第3期339-346,共8页Qing-Lan Lyu Bi-Mei Jiang Bin Zhou Li Sun Zhong-Yi Tong Yuan-Bin Li Yu-Ting Tang Hui Sun Mei-Dong Liu Xian-Zhong Xiao; Background：Nucleolin （NCL） is the most abundant RNA-binding protein in the cell nucleolus and plays an important role in chromatin stability,ribosome assembly,ribosomal RNA maturation,ribosomal DNA transcription,nu...; 关键词：MicroRNA microarray MYOCARDIUM NUCLEOLIN Transgenic mice

Differential expression of nucleolin in colon adenoma and adenocarcinoma被引量：1: 《Oncology and Translational Medicine》2017年第2期82-85,共4页Guozhao Meng Junlei Yi Ming Xie; Objective The aim of the study was to investigate the discrepancy in nucleolin expression between colon adenoma and colon adenocarcinoma,explore the role of nucleolin expression in the carcinogenesis of colon adenocar...; 关键词：NUCLEOLIN COLON ADENOMA COLON ADENOCARCINOMA

Selective alkylation and bioactivity of phosphorothioated nucleolin aptamer AS1411被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2017年第1期23-30,共8页张光普邓家荔杨先桃朱月洁关注张礼和杨振军; the Ministry of Science and Technology of China(Grant No.2012CB720604);National Natural Science Foundation of China(Grant No.21332010); An operationally simple and efficient method for the synthesis of a wide range of alkylated nucleotides under mild conditions was developed. This improved method furnishes alkylated nucleotides fi＇om both single nucl...; 关键词：Phosphorothioated nucleotide ALKYLATION APTAMER AS 1411 NUCLEOLIN

Nucleolin在结肠癌中的表达变化及其临床意义被引量：1: 《中华普外科手术学杂志（电子版）》2016年第6期523-526,共4页张翊刁永鹏韩旭东吴致委李强许庆; 目的探讨Nucleolin蛋白在结肠癌组织中的表达及其临床病理学意义。方法选取2010年1月至2015年8月结肠癌病理组织标本70例（结肠癌组）和本院病理科既往收集的20例正常结肠组织（正常组）进行免疫组织化学检测,利用统计软件SAS9.1,分析...; 关键词：结肠肿瘤核仁蛋白质类病理学临床

Nucleolin与VEGF在结肠癌中的表达及其与转移的关系被引量：5: 《肿瘤预防与治疗》2015年第1期18-21,共4页林冰雷晴郎锦义王春婷; 目的:研究Nucleolin与VEGF在结肠癌中的表达以及与临床病理特征之间的关系。方法:采用免疫组化法检测组织芯片60例结肠癌组织中Nucleolin与VEGF蛋白的表达。分析其与结肠癌临床病理特征之间的关系。结果:VEGF阳性表达于细胞浆,在正常结...; 关键词：NUCLEOLIN VEGF 结肠癌转移

NUCLEOLIN