PARKINSON_DISEASE

作品数：125被引量：198H指数：7
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相关机构：首都医科大学附属北京天坛医院福建医科大学环境与疾病相关基因教育部重点实验室西安交通大学更多>>
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Research progress in mechanism of curcumin in treatment of Parkinson disease
《中国药理学与毒理学杂志》2021年第10期776-777,共2页YUAN Xin-ru JING Yong-shuai ZHANG Dan-shen 
Key Research and Development Program of Hebei Province(20370509D);and Science and Technology Project of Hebei Education Department(ZD2020117)。
Curcumin(Cur)is an important bioactive component of polyphenols in the rhizomes of Curcuma longa L.,Tulipa gesneriana L.and other Curcuma plants.It has a wide range of pharmacological effects such as anti-tumor,anti-a...
关键词：CURCUMIN Parkinson disease mechanism of action 
Roles of NAMPT and NAD decline in patho⁃genesis of Parkinson disease in mice被引量：1
《中国药理学与毒理学杂志》2021年第9期652-653,共2页CHEN Cong SHEN Chen GAO Tong-yao WANG Tong LU Yun-bi ZHANG Wei-ping 
OBJECTIVE Nicotinamide phos⁃phoribosyltransferase(NAMPT)is the key enzyme for the synthesis of nicotinamide ade⁃nine dinucleotide(NAD)in the salvaging pathway.NAD is an essential co-enzyme of multiple enzymes involved...
关键词：nicotinamide phosphoribosyltrans⁃ferase nicotinamide adenine dinucleotide MYELIN dopaminergic neurons 
Glutathione peroxidase 4 deficit-mediated fer⁃roptosis contributes to dopaminergic neuron degeneration under synucleinopathy
《中国药理学与毒理学杂志》2021年第9期645-646,共2页SUN Jie LU Dan-hua LI Kun LIN Xiao-min PAN Ming-hai GONG Hai-biao SUN Wan-yang WANG Meng LIANG Lei Kurihara Hiroshi LI Yi-fang DUAN Wen-jun ZHANG Li HE Rong-rong 
National Key Research and Development Program of China(2017YFC1700404);Natural Science Foundation of China(81873209);Natural Science Foundation of China(U1801284);Natural Science Foundation of China(81903821);Natural Science Foundation of China(81973718);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036);GDUPS(2019),Fun⁃damental Research Funds for the Central Univer⁃sities(21620448);Natural Science Foundation of Guangdong Province(2019A 1515010909);Nat⁃ural Science Foundation of Guangdong Prov⁃ince(2021A1515011297);Science and Tech⁃nology Program of Guangzhou(201903010062);Science and Technology Program of Guang⁃zhou(907158833068),and the Innovation Team Project of Guangdong Provincial Department of Education(2020KCXT D003)。
OBJECTIVE Intracellular aggre⁃gation ofα-synuclein(SNCA)is one of the core pathological features of neurodegenerative disor⁃ders including Parkinson disease,whilst the detailed mechanism for consequently neuron loss ...
关键词：Parkinson disease ferroptosis glutathione peroxidase-4 phospholipid-omics Α-SYNUCLEIN 
Urolithin A protects dopaminergic neurons in experimental models of Parkinson disease by promoting mitochondrial biogenesis through SIRT1/PGC-1αsignaling pathway
《中国药理学与毒理学杂志》2021年第9期648-649,共2页LIU Jia QIU jing-ru WANG Bao-zhu SUN De-qing YU Shu-yan LOU Hai-yan 
OBJECTIVE Mitochondrial dys⁃function contributes to the pathogenesis of neuro⁃degenerative diseases such as Parkinson dis⁃ease(PD).Therapeutic strategies targeting mito⁃chondrial dysfunction hold considerable promise ...
关键词：urolithin A Parkinson disease mito⁃chondrial biogenesis 
Metabolic aspects behind ageing and neurodegeneration reveal new ways forward for therapy in motorneurone(ALS) and Parkinson diseases
《中国药理学与毒理学杂志》2019年第10期754-754,共1页A BOUSCARY C QUESSADA A HENRIQUES JP LOEFFLER M SPEDDING 
Human beings evolved to run over a relatively short evolutionary time scale, ~1 million years, 2-3 million years ago, markedly increasing metabolic rate and VO2max, compared with other primates, while increasing brain...
关键词：METABOLISM ageing-related diseases motorneurone Parkinson disease 
Tetramethylpyrazine analogue T-006 promotes clearance of alpha-synuclein by enhancing proteasome activity in Parkinson disease models被引量：1
《中国药理学与毒理学杂志》2019年第9期658-659,共2页ZHOU He-feng SHAO Min GUO Bao-jian LI Chu-wen LU Yu-cong YANG Xuan-jun LI Sheng-nan LI Hai-tao ZHU Qi ZHONG Han-bing WANG Yu-qiang ZHANG Zai-jun LU Jia-hong LEE Ming-yuen Simon 
Science and Technology Development Fund(FDCT)of Macao SAR(069/2015/A2;134/2014/A3;062-2017-AIR);Research Committee,University of Macao(MYRG2015-00182-ICMS-QRCM;MYRG2015-00214-ICMSQRCM;MYRG139(Y1-L4)-ICMS12-LMY;and MYRG2016-00129-ICMS-QRCM)
OBJECTIVE To investigate the effects of T-006(tetramethylpyrazine derivative)in promotingα-Synuclein(α-Syn)degradation and evaluated the neuroprotective effects in cellular and animalα-Syn model of Parkinson diseas...
关键词：Α-SYNUCLEIN degradation LMP7 proteasome activity Parkinson disease 
Histone deacetylase 6 mediated NALP3 inflammasome activation contributes to dopaminergic injury in experimental models of Parkinson disease
《中国药理学与毒理学杂志》2018年第9期686-687,共2页YAN Shao-qi WEI Xin-bing JIAN Wen-cheng QIN Yue JIANG Fan LOU Hai-yan ZHANG Bin 
Key Technologies Research and Development Program of Shandong Province (2017GSF18171,2018GSF118139).
OBJECTIVE To investigate the mechanisms of histone deacetylase 6(HDAC6)deacetylation activity on NALP3 inflammasome activation and explore the protective effect s of pharmacological inhibition of HDAC6 on dopaminergic...
关键词：HISTONE DEACETYLASE 6 NALP3 PEROXIREDOXIN 2 reactive oxygen species 
Upregulation of TREM2 attenuates neuroinflammation and dopaminergic neurotoxicity in MPTP model mice with Parkinson disease
《中国药理学与毒理学杂志》2018年第9期684-684,共1页REN Man-ru GUO Ying WEI Xin-bing YAN Shao-qi QIN Yue ZHANG Bin LOU Hai-yan 
Shandong Province Science and Technology Program (2016GSF201061).
OBJECTIVE To investigate the role of triggering receptor expressed on myeloid cells-2(TREM2) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) model mice with Parkinson disease(PD) and explore the underlying s...
关键词：triggering receptor expressed on MYELOID cells-2 PARKINSON disease microglia NEUROINFLAMMATION 
Research progress on pharmacological effect and mechanism of baicalein in Parkinson diseases被引量：3
《中国药理学与毒理学杂志》2018年第4期341-342,共2页Xiao-yue ZHAO Hai-gang WANG Qi-meng ZHOU Ping HE Guan-hua DU 
supported by National Key R＆D Plan(2016YFC1000905)
Parkinson disease(PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and deposition of cytosolic inclusions in surviving neurons(Lewy bodies),resulting in motor deficits and non-motor sym...
关键词：帕金森病 治疗方法 黄芩素 临床分析 
Protective role of brain CYP2J in diverse Parkinson disease animal models
《中国药理学与毒理学杂志》2017年第10期967-968,共2页Yue-ran LI Xu-ming YU Zhe-qiong YANG Xian-fei YUE Jiang XIE 
supported by New Century Excellent Talents in University(NCET-11-0399);National Natural Science Foundation of China(81673503)
OBJECTIVE CYP2 family including CYP2C and CYP2J is the predominant arachidonic acid(AA)epoxygenase,and the epoxidation of AA produces four regioisomeric cis-epoxyeicosatrienoic acids(5,6-,8,9-,11,12-,and 14,15-EET).Hu...
关键词：Parkinson disease CYP2C and CYP2J animal models 
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