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PARKINSON_DISEASE: 作品数：125被引量：198H指数：7; 导出分析报告; 相关作者：余舒扬陈滢陈晓春王涛张巧俊更多>>; 相关机构：首都医科大学附属北京天坛医院福建医科大学环境与疾病相关基因教育部重点实验室西安交通大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金北京市自然科学基金国家重点基础研究发展计划陕西省自然科学基金更多>>

Emerging role of microglia in the developing dopaminergic system:Perturbation by early life stress: 《Neural Regeneration Research》2026年第1期126-140,共15页Kaijie She Naijun Yuan Minyi Huang Wenjun Zhu Manshi Tang Qingyu Ma Jiaxu Chen; supported by the National Natural Science Foundation of China,Nos.82304990(to NY),81973748(to JC),82174278(to JC);the National Key R&D Program of China,No.2023YFE0209500(to JC);China Postdoctoral Science Foundation,No.2023M732380(to NY);Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine,No.202102010014(to JC);Huang Zhendong Research Fund for Traditional Chinese Medicine of Jinan University,No.201911(to JC);National Innovation and Entrepreneurship Training Program for Undergraduates in China,No.202310559128(to NY and QM);Innovation and Entrepreneurship Training Program for Undergraduates at Jinan University,Nos.CX24380,CX24381(both to NY and QM)。; Early life stress correlates with a higher prevalence of neurological disorders,including autism,attention-deficit/hyperactivity disorder,schizophrenia,depression,and Parkinson's disease.These conditions,primarily inv...; 关键词：Chinese herbal drugs dopamine early life stress epigenetics gut-brain axis hypothalamo–pituitary–adrenal axis innate immune memory MICROGLIA neuroinflammation Parkinson disease PHAGOCYTOSIS REWARD

Correlations of transcranial sonography of substantia nigra characteristics with MRI iron deposition on substantia nigra in patients with Parkinson disease: 《中国医学影像技术》2024年第8期1160-1163,共4页ZOU Quan CHEN Fei MENG Wenyu ZHENG Hong; Objective To explore the correlations of transcranial sonography of substantia nigra(SN-TCS)characteristics with MRI iron deposition on substantia nigra in patients with Parkinson disease(PD).Methods Data of SN-TCS an...; 关键词：Parkinson disease substantia nigra IRON ULTRASONOGRAPHY magnetic resonance imaging

Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy被引量：1: 《World Journal of Gastroenterology》2024年第3期225-237,共13页Xin-Yang Yuan Yu-Sen Chen Zhou Liu; This comprehensive review elucidates the complex interplay between gut microbiota and constipation in Parkinson’s disease(PD),a prevalent non-motor symptom contributing significantly to patients’morbidity.A marked a...; 关键词：Parkinson disease CONSTIPATION Gut microbiota PREBIOTICS PROBIOTICS Fecal microbiota transplantation

Gene therapy for Parkinson’s Disease and Ethical Challenges: A Systematic Review: 《Advances in Parkinson's Disease》2023年第2期9-28,共20页Théodora M. Zohoncon Joseph Sawadogo Abdou Azaque Zoure Abdoul Karim Ouattara Marie N. L. Ouedraogo Luc Zongo Paul Ouedraogo Florencia W. Djigma Christelle W. M. Nadembèga Raphael Kabore Djénéba Ouermi Dorcas Obiri-Yeboah Jacques Simpore; Background: Parkinson’s disease (PD) is a complex, multifactorial neurodegenerative disorder with a pathophysiology deriving from the synergy of abnormal aggregation of neuroinflammation, synuclein and dysfunction of...; 关键词：Neurodegenerative Diseases Parkinson Disease Molecular Mechanism Gene Therapy Gene Therapy Ethics

Bifurcations for counterintuitive post-inhibitory rebound spike related to absence epilepsy and Parkinson disease: 《Chinese Physics B》2023年第9期206-219,共14页王宪军古华光贾雁兵陆博周辉; the National Natural Science Foundation of China(Grant Nos.12072236,11872276,and11802086);the Postdoctoral Research Project of Henan Province,China(Grant No.19030095);the Science and Technology Development Program of Henan Province,China(Grant No.212102210543)。; Seizures are caused by increased neuronal firing activity resulting from reduced inhibitory effect and enhancement of inhibitory modulation to suppress this activity is used as a therapeutic tool.However,recent experi...; 关键词：bifurcation threshold post-inhibitory rebound spike brain disease

Efficacy and safety of light therapy for Parkinson disease被引量：2: 《Chinese Medical Journal》2022年第7期878-880,共3页Yanghong Li Xiaoxia Zhou Xinyin Wu Beisha Tang; the National Natural Science Foundation of China(No.81430023)。; To the Editor:Parkinson disease(PD)is the second most common neurodegenerative disorder associated with significant disability and negative impact on quality of life(QoL),affecting 2%to 3%of the population≥65 years o...; 关键词：IMPAIRMENT RIGIDITY typically

Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease被引量：2: 《Translational Neurodegeneration》2022年第1期390-400,共11页Matilde Bongianni Mauro Catalan Daniela Perra Elena Fontana Francesco Janes Claudio Bertolotti Luca Sacchetto Stefano Capaldi Matteo Tagliapietra Paola Polverino Valentina Tommasini Giulia Bellavita Elham Ataie Kachoie Roberto Baruca Andrea Bernardini Mariarosaria Valente Michele Fiorini Erika Bronzato Stefano Tamburin Laura Bertolasi Lorenzo Brozzetti Maria Paola Cecchini Gianluigi Gigli Salvatore Monaco Paolo Manganotti Gianluigi Zanusso; Fondazione Cariverona:“Development and validation of a novel molecular assay forα-synuclein in patients with Parkinson’s disease and otherα-synucleinopathies”#2018.0708 to GZ and Brain Research Verona Foundation to GZ.Dr.Elena Fontana is attending a doctoral fellowship supported by COPAN group.; Background: In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucle...; 关键词：Parkinson disease ALPHA-SYNUCLEIN Real-time quaking-induced conversion assay Olfactory mucosa Cerebrospinal fluid

Effect of Varenicline on Detrusor Overactivity in Rat Model of Parkinson’s Disease Induced by Intranigral 6-Hydroxydopamine: 《Advances in Parkinson's Disease》2022年第1期1-10,共10页Zeynep Mine Altunay Fatma Rüyal Tan Nermin Bölükbaşı Funda Fatma Bölükbaşı Hatip Izzettin Hatip-Al-Khatib; Background: Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Bladder dysfunction is the common non-motor symptom of PD, most often presenting with ...; 关键词：Nicotinic Cholinergic Receptors Overactive Bladder VARENICLINE Parkinson Disease Alpha7 Nicotinic Cholinergic Receptor Agonists

Roles of NAMPT and NAD decline in patho⁃genesis of Parkinson disease in mice被引量：1: 《中国药理学与毒理学杂志》2021年第9期652-653,共2页CHEN Cong SHEN Chen GAO Tong-yao WANG Tong LU Yun-bi ZHANG Wei-ping; OBJECTIVE Nicotinamide phos⁃phoribosyltransferase(NAMPT)is the key enzyme for the synthesis of nicotinamide ade⁃nine dinucleotide(NAD)in the salvaging pathway.NAD is an essential co-enzyme of multiple enzymes involved...; 关键词：nicotinamide phosphoribosyltrans⁃ferase nicotinamide adenine dinucleotide MYELIN dopaminergic neurons

Glutathione peroxidase 4 deficit-mediated fer⁃roptosis contributes to dopaminergic neuron degeneration under synucleinopathy: 《中国药理学与毒理学杂志》2021年第9期645-646,共2页SUN Jie LU Dan-hua LI Kun LIN Xiao-min PAN Ming-hai GONG Hai-biao SUN Wan-yang WANG Meng LIANG Lei Kurihara Hiroshi LI Yi-fang DUAN Wen-jun ZHANG Li HE Rong-rong; National Key Research and Development Program of China(2017YFC1700404);Natural Science Foundation of China(81873209);Natural Science Foundation of China(U1801284);Natural Science Foundation of China(81903821);Natural Science Foundation of China(81973718);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036);GDUPS(2019),Fun⁃damental Research Funds for the Central Univer⁃sities(21620448);Natural Science Foundation of Guangdong Province(2019A 1515010909);Nat⁃ural Science Foundation of Guangdong Prov⁃ince(2021A1515011297);Science and Tech⁃nology Program of Guangzhou(201903010062);Science and Technology Program of Guang⁃zhou(907158833068),and the Innovation Team Project of Guangdong Provincial Department of Education(2020KCXT D003)。; OBJECTIVE Intracellular aggre⁃gation ofα-synuclein(SNCA)is one of the core pathological features of neurodegenerative disor⁃ders including Parkinson disease,whilst the detailed mechanism for consequently neuron loss ...; 关键词：Parkinson disease ferroptosis glutathione peroxidase-4 phospholipid-omics Α-SYNUCLEIN

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