supported by the National Key R&D Program of China(No.2022YFC3501900);Beijing Natural Science Foundation(Nos.L222127 and L212013);AI + Health Collaborative Innovation Cultivation Project(No.Z211100003521002);the National Natural Science Foundation of China(No.U20A20412).
Compared with thermodynamically equilibrium supramolecular assemblies, non-equilibrium assemblies from the same building blocks have attracted increasing attentions because their diverse structures and dynamic natures...
supported by grants from the National Natural Science Foundation of China(Nos.32000998 and 32201240);The Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology(No.2022HYTP046);the China Postdoctoral Science Foundation(No.2021TQ0298);Science and Technology Development Project of Henan Province(Nos.222102310525,232102310351);National College Students’innovation and entrepreneurship training program(No.202310459197).
Breast cancer remains a leading cause of morbidity and mortality among women worldwide,emphasizing the urgent need for enhanced diagnostic and therapeutic approaches.Leucine-rich-alpha-2-glycoprotein 1(LRG1)has emerge...
financial support from National Natural Science Foundation of China(Nos.22178270,22078246,82103984,and U23A2089).
To address the limitations of conventional nanotechnology-based drug delivery systems,this work developed enzyme and reduction dual-responsive polymeric micelles.These micelles were synthesized with copolymers compose...
supported by the National Natural Science Foundation of China(Nos.22074128 and 22241503);Fundamental Research Funds for the Central Universities(Nos.20720210013 and 20720220005).
Controlled peptide assembly offers significant promise to develop synthetic supramolecular nanostructures to display material and biological properties that mimic protein assemblies in nature.Despite the progress in f...
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB36000000);the National Key R&D Program of China(No.2022YFA1203200);the National Natural Science Foundation of China(No.32027801).
Peptide-modified delivery systems are enabling the improvement of the targeting specificity,biocompatibility,stability,etc.However,the precise design of a peptide-decorated surface for a designated function has remain...
This work was supported by the National Key Research and Development Program of China(No.2022YFE0107800);National Natural Science Foundation of China(Nos.82073332,and 81673022)。
Orally administered peptides or proteins are garnering increasing preference owing to their superiority in terms of patient compliance and convenience.However,the development of oral protein formulations has stalled d...
supported by the National Natural Science Foundation of China(No.22074006);Beijing Natural Science Foundation(No.2222029);Beijing Institute of Technology Research Fund Program for Young Scholars.
Despite recent advances in melanoma treatment through the use of antibody immunotherapy,the clinical benefit remains restricted by its inefficient infiltration and immunosuppression within the tumor microenvironment(T...
This work was funded by a National Research Foundation of Korea(NRF)grant from the Korean government(MSIT)(No.2020R1A2C2004864);S.D.N.acknowledges the support by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(No.HI19C1234).
The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently required.Memristors have...
the National Key Research and Development(R&D)Program of China(No.2021YFB3800900);the Natural Science Foundation of China(Nos.51725303,21708031,and 52033007);the National Postdoctoral Program for Innovative Talents(No.BX20180264);China Postdoctoral Science Foundation(No.2018M643519);the Sichuan Science and Technology Program(No.2020JDRC0051);the Fundamental Research Funds for the Central Universities(No.2682021ZTPY075)。
The practical application of nanomedicines for cancer therapy is generally hampered by their compromised tumor accumulation and transmembrane potency.Cell penetrating peptides(CPPs)have been widely used to enhance the...
the National Key Research and Development Program of China(No.2019YFA0905200);the National Natural Science Foundation of China(No.82072045);the Natural Science Foundation of Jiangsu Province of China for Excellent Young Scholars(No.BK20190084).
Proteins have been widely used in the biomedical field because of their well-defined architecture,accurate molecular weight,excellent biocompatibility and biodegradability,and easy-to-functionalization.Inspired by the...