PEPTIDE

作品数:1070被引量:2052H指数:15
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相关领域:医药卫生更多>>
相关作者:杨松成张学敏张滨魏开华王红霞更多>>
相关机构:北京大学福建医科大学复旦大学军事医学科学院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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Engineering and preliminary evaluation of multiple non-equilibrium nanostructures from a single peptide amphiphile
《Nano Research》2024年第11期9764-9774,共11页Weiping Cui Di Wu Liuqing Yang Chang Yang Bing He Hua Zhang Xueqing Wang Lei Zhang Wenbing Dai Qiang Zhang 
supported by the National Key R&D Program of China(No.2022YFC3501900);Beijing Natural Science Foundation(Nos.L222127 and L212013);AI + Health Collaborative Innovation Cultivation Project(No.Z211100003521002);the National Natural Science Foundation of China(No.U20A20412).
Compared with thermodynamically equilibrium supramolecular assemblies, non-equilibrium assemblies from the same building blocks have attracted increasing attentions because their diverse structures and dynamic natures...
关键词:non-equilibrium nanostructures peptide amphiphile peptide assembly NANOMEDICINE 
Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer
《Nano Research》2024年第10期9044-9051,共8页Mengdie Chen Anying Zhu Furong Zhu Ziwen Lei Tao Huang Shengnan Du Dongdong Wang Xiaoyu Zhang Huan Min Yingqiu Qi Guangjun Nie 
supported by grants from the National Natural Science Foundation of China(Nos.32000998 and 32201240);The Young Elite Scientists Sponsorship Program by Henan Association for Science and Technology(No.2022HYTP046);the China Postdoctoral Science Foundation(No.2021TQ0298);Science and Technology Development Project of Henan Province(Nos.222102310525,232102310351);National College Students’innovation and entrepreneurship training program(No.202310459197).
Breast cancer remains a leading cause of morbidity and mortality among women worldwide,emphasizing the urgent need for enhanced diagnostic and therapeutic approaches.Leucine-rich-alpha-2-glycoprotein 1(LRG1)has emerge...
关键词:breast cancer leucine-rich-alpha-2-glycoprotein 1(LRG1) phage display PEPTIDE tumor targeting 
Nanoscale“precision strike”:Tumor microenvironment-responsive smart micelles for efficient targeted drug delivery
《Nano Research》2024年第9期8360-8367,共8页Dong Wan Yarong Song Xiujuan Lu Yanfeng Huang Jianxin Zhang Yonghui Liu Yi Liu Jie Pan 
financial support from National Natural Science Foundation of China(Nos.22178270,22078246,82103984,and U23A2089).
To address the limitations of conventional nanotechnology-based drug delivery systems,this work developed enzyme and reduction dual-responsive polymeric micelles.These micelles were synthesized with copolymers compose...
关键词:CANCER PEPTIDE MICELLE dual-responsive folate 
Assembly of peptide nanostructures with controllable sizes
《Nano Research》2024年第1期151-161,共11页Dan Cheng Fan Jia Yun-Bao Jiang Vincent P.Conticello Tao Jiang 
supported by the National Natural Science Foundation of China(Nos.22074128 and 22241503);Fundamental Research Funds for the Central Universities(Nos.20720210013 and 20720220005).
Controlled peptide assembly offers significant promise to develop synthetic supramolecular nanostructures to display material and biological properties that mimic protein assemblies in nature.Despite the progress in f...
关键词:peptide assembly controllable size TEMPLATE MULTI-COMPONENT 
Terminus-immobilization effect on peptide conformations and peptide–peptide interactions
《Nano Research》2023年第12期13498-13508,共11页Wendi Luo Xiaocui Fang Chen Wang Yanlian Yang Bin Tu Qiaojun Fang 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB36000000);the National Key R&D Program of China(No.2022YFA1203200);the National Natural Science Foundation of China(No.32027801).
Peptide-modified delivery systems are enabling the improvement of the targeting specificity,biocompatibility,stability,etc.However,the precise design of a peptide-decorated surface for a designated function has remain...
关键词:terminus-immobilization peptide conformations peptide–peptide interactions molecular dynamics peptide design 
Membrane fusion reverse micelle platforms as potential oral nanocarriers for efficient internalization of free hydrophilic peptides被引量:1
《Nano Research》2023年第7期9768-9780,共13页Mengting Lin Linjie Wu Yiying Lu Xiaoyan Bao Haiqing Zhong Qi Dai Qiyao Yang Yiyi Xia Xin Tan Yaxin Qin Ruolin Jiang Min Han 
This work was supported by the National Key Research and Development Program of China(No.2022YFE0107800);National Natural Science Foundation of China(Nos.82073332,and 81673022)。
Orally administered peptides or proteins are garnering increasing preference owing to their superiority in terms of patient compliance and convenience.However,the development of oral protein formulations has stalled d...
关键词:oral drug delivery system reverse micelle self-emulsifying drug delivery system membrane fusion hydrophilic peptide 
A composite peptide-supramolecular microneedle system for melanoma immunotherapy被引量:3
《Nano Research》2023年第4期5335-5345,共11页Mengzhen Li Minxuan Wang Lingyun Li Limin Zhang Bing Ma Weizhi Wang 
supported by the National Natural Science Foundation of China(No.22074006);Beijing Natural Science Foundation(No.2222029);Beijing Institute of Technology Research Fund Program for Young Scholars.
Despite recent advances in melanoma treatment through the use of antibody immunotherapy,the clinical benefit remains restricted by its inefficient infiltration and immunosuppression within the tumor microenvironment(T...
关键词:targeting peptide cascaded drug delivery MICRONEEDLE immune checkpoint blockade self-assembly 
Tyrosine-mediated analog resistive switching for artificial neural networks被引量:1
《Nano Research》2023年第1期858-864,共7页Min-Kyu Song Seok Daniel Namgung Hojung Lee Jeong Hyun Yoon Young-Woong Song Kang Hee Cho Yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon Kwon 
This work was funded by a National Research Foundation of Korea(NRF)grant from the Korean government(MSIT)(No.2020R1A2C2004864);S.D.N.acknowledges the support by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(No.HI19C1234).
The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently required.Memristors have...
关键词:artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network 
pH-activatable lactam-stapled peptide-based nanoassemblies for enhanced chemo-photothermal therapy被引量:1
《Nano Research》2022年第9期8315-8325,共11页Yao Xiao Ling Zhang Mengzhen Shi Rui Tang Zherui Jiang Yue Song Yuan Tian Shaobing Zhou 
the National Key Research and Development(R&D)Program of China(No.2021YFB3800900);the Natural Science Foundation of China(Nos.51725303,21708031,and 52033007);the National Postdoctoral Program for Innovative Talents(No.BX20180264);China Postdoctoral Science Foundation(No.2018M643519);the Sichuan Science and Technology Program(No.2020JDRC0051);the Fundamental Research Funds for the Central Universities(No.2682021ZTPY075)。
The practical application of nanomedicines for cancer therapy is generally hampered by their compromised tumor accumulation and transmembrane potency.Cell penetrating peptides(CPPs)have been widely used to enhance the...
关键词:lactam-stapled peptide PH-RESPONSIVE NANOASSEMBLIES CHEMOTHERAPY photothermal therapy 
Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development被引量:1
《Nano Research》2022年第8期7267-7285,共19页Taiyu Liu Lu Li Cheng Cheng Bingfang He Tianyue Jiang 
the National Key Research and Development Program of China(No.2019YFA0905200);the National Natural Science Foundation of China(No.82072045);the Natural Science Foundation of Jiangsu Province of China for Excellent Young Scholars(No.BK20190084).
Proteins have been widely used in the biomedical field because of their well-defined architecture,accurate molecular weight,excellent biocompatibility and biodegradability,and easy-to-functionalization.Inspired by the...
关键词:drug delivery VACCINE protein/peptide SELF-ASSEMBLY targeting controlled release 
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