云南高校图书馆联盟文献共享服务平台- STAUROSPORINE

STAUROSPORINE: 作品数：48被引量：126H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王晓明薛绍白李源刘艳张卫卫更多>>; 相关机构：第四军医大学西京医院北京师范大学军事医学科学院华中农业大学更多>>; 相关期刊：《Chinese Medical Journal》《生理通讯》《药学学报》《天然产物研究与开发》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金湖北省自然科学基金更多>>

Staurosporine targets the Hippo pathway to inhibit cell growth: 《Journal of Molecular Cell Biology》2018年第3期267-269,共3页Xueyan Ma Peixue Li Peihao Chen Jinhui Li Hongling Huang Chao Wang Wenjing Li Jianping Ding Yun Zhao Fa-Xing Yu Xiangbing Qi Lei Zhang; This work was supported by the ＇Strategic Priority Research Program＇ of the Chinese Academy of Sciences （XDB19000000）, the National Key Research and Development Program of China （2017YFA0103601）, the National Natural Science Foundation of China （31530043 and 31625017）, the ＇Cross and Cooperation in Science and Technology Innovation Team＇ Project of the Chinese Academy of Sciences, and the CAS/SAFEA International Partnership Program for Creative Research Teams.; The Hippo signaling pathway was discovered to control organ size in Drosophila through regulating cell proliferation and apoptosis （Yu et al., 2015）. Arising studies over the past two decades have defined the core c...; 关键词：STAUROSPORINE 小径河马 APOPTOSIS 生长房间指向核心部件

Probe Staurosporine Drug Binding Site on Protein Kinase by PFSC: 《Chemical Research in Chinese Universities》2014年第4期644-649,共6页ZHENG Kun YANG Hong ZHAO Xiaofei JIANG Yang SUN Chuantao YANG Jia'an; Supported by the National Natural Science Foundation of China（Nos.20771030, 20671025）.Acknowledgements We are thankful to HAN Weiwei and WANG Ye in the Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University for assistance in using the computational facilities.; We used a new approach,protein folding shape code（PFSC）,to predict the potential staurosporine binding sites in protein kinases.Firstly,all available three dimensioned（3D） structures of protein kinases in protein ...; 关键词：STAUROSPORINE Adenosine triphosphate（ATP）-binding site Protein fold shape code（PFSC） Protein folding structural alignment（PFSA） Protein databank（PDB）

Curcumin protects against staurosporine toxicity in rat neurons: 《Neuroscience Bulletin》2012年第5期606-610,共5页Xiao-Yan Qin Ji-Hui Lv Jia Cui Xue Fang Yan Zhang; supported by the National Basic Research Development Program of China(2009CB941301);the National Natural Science Foundation of China (91132718, 30701138);the Peking University President Research Grant;the Ministry of Education Recruiting Research Grant;the Fundamental Research Funds for the Central Universities of China (1112KYZY41);the "985 Project" of Minzu University, China (MUC98504-14); Objective Curcumin is extracted from the turmeric plant （Curcuma longa Linn.） and is widely used as a food additive and traditional medicine. The present study investigated the activity of curcumin against staurospo...; 关键词：CURCUMIN staurosporine-induced cytotoxicity hippocampal neurons caspase-3 Akt Hsp70 reactive oxygen species cancer treatment

Contractile effect of tachykinins on rabbit sma intestine被引量：6: 《Acta Pharmacologica Sinica》2011年第4期487-494,共8页Marta Sofia VALERO Diego Santos FAGUNDES Laura GRASA Maria Pilar ARRUEBO Miguel Angel PLAZA Maria Divina MURILLO; Aim： To study the role of the tachykinin receptors in spontaneous contractions of longitudinal and circular smooth muscle from rabbit small intestine and to determine the mechanism of action of Substance P （SP）. Me...; 关键词：tachykinin receptors substance P small intestine RABBITS STAUROSPORINE U73122 L-733 060 GR-94800 SB 218795

海洋链霉菌Streptomyces sp.SCSIO 1667中吲哚咔唑生物碱类成分的研究被引量：8: 《天然产物研究与开发》2011年第3期415-419,共5页周俊勇黄洪波汪中文杨民和田新朋张偲张长生鞠建华; 中国科学院知识创新工程重要方向项目(KSCX2-YW-G-065;KZCX2-YW-JC202;KSCX2-EW-G-12);中国科学院南海海洋所领域前沿项目(LYQY200805); 运用大孔树脂柱及硅胶柱层析对南海海洋链霉菌Streptomyces sp.SCSIO 1667的代谢产物进行了研究,从SCSIO 1667菌株的发酵产物中分离得到两个indolocarbazole生物碱类化合物,经质谱,1D、2D NMR波谱数据分析鉴定为星形孢菌素(staurosporin...; 关键词：海洋放线菌 STREPTOMYCES sp.SCSIO 1667 STAUROSPORINE K-252d

Crystal Structure of the MAP3K TAO2 Kinase Domain Bound by an Inhibitor Staurosporine: 《Acta Biochimica et Biophysica Sinica》2006年第6期385-392,共8页Tian-Jun ZHOU Li-Guang SUN Yan GAO Elizabeth J. GOLDSMITH; This research was supported by Nationai Institutes of Health(USA)grants DK46993 and GM53032 and grants I1128 and I1143 from the Welch Foundation; Mitogen-activated protein kinase （MAPK） signal transduction pathways are ubiquitous in eukaryotic cells, which transfer signals from the cell surface to the nucleus, controlling multiple cellular programs. MAPKs are...; 关键词：TAO2 MAP3K INHIBITOR STAUROSPORINE crystal structure

蛋白激酶C抑制剂Staurosporine对A类清道夫受体胞浆域结构去除后功能的影响被引量：3: 《生物化学与生物物理进展》2004年第8期693-698,共6页管晓翔陈琪范乐明; 国家重点基础研究发展规划项目 ( 973 ) (TG2 0 0 0 5 6910 );江苏省科委应用基础资助项目 (BK2 0 0 1113 )~~; A类清道夫受体 (scavengerreceptor,SR A)是一种主要位于巨噬细胞膜表面的同源三聚体糖蛋白 ,能够结合和摄取多种配基并介导内移 .在清道夫受体胞浆域有几个潜在的磷酸化位点 ,有关这些磷酸化位点与受体功能之间的确切关系目前尚所知甚...; 关键词：A类清道夫受体胞浆域磷酸化蛋白激酶C抑制剂巨噬细胞

The Effect of Mutant Inhibitor of Caspase-ActivatedDNase on Apoptosis Induced by Staurosporine: 《Wuhan University Journal of Natural Sciences》2004年第3期397-398,共2页ZhangWen ZhangBai-fang PengFang-fang WuDong-cheng

Staurosporine诱导小鼠心肌细胞凋亡模型的构建(英文)被引量：2: 《心脏杂志》2004年第1期4-10,共7页王晓明臧益民高峰龚卫琴李源; 目的 :Staurosporine可诱导不同细胞类型的细胞凋亡 ,但尚缺乏其对小鼠心肌细胞作用影响的报道。本研究旨在观察 Staurosporine是否也可引起小鼠心肌细胞的凋亡 ,并对其模型进行分子水平的鉴定。方法 :用 Stau-rosporine处理原代培养的...; 关键词：心肌细胞小鼠细胞凋亡 STAUROSPORINE CASPASE-3 乳酸脱氢酶

蛋白激酶C抑制剂staurosporine对HeLa细胞周期的影响被引量：4: 《中国生物化学与分子生物学报》1998年第1期113-11,共1页石法武任洪波张兆山王会信周廷冲; 蛋白激酶Ｃ抑制剂ｓｔａｕｒｏｓｐｏｒｉｎｅ对ＨｅＬａ细胞周期的影响石法武＊任洪波张兆山＊＊王会信周廷冲（军事医学科学院基础医学研究所，＊＊生物工程研究所，北京１００８５０Ｔｈｅｅｆｅｃｔｏｆｓｔａｕｒｏｓｐｏｒｉｎｅ...; 关键词：蛋白激酶抑制剂 HELA 细胞周期

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