THE_ACT

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Combined in silico/in vitro approaches for identifying modulators of the activity of the p.Tyr110Cys Carnitine O-Acetyltransferase(CRAT)variant associated to an early onset case of Leigh syndrome
《Acta Pharmacologica Sinica》2025年第4期1123-1136,共14页Lucas Cafferati Beltrame Maria Noemi Sgobba Luna Laera Valeria Scaglione Sabino Todisco Serena Barile Anna Lucia Francavilla Danila Imperia De Luca Michele Montaruli Vito Porcelli Lorenzo Guerra Anna De Grassi Mariateresa Volpicella Ciro Leonardo Pierri 
supported by EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases(Project No.PE00000007,INF‐ACT);MUR PNRR National Center for Gene Therapy and Drugs based on RNA Technology(Project No.CN_00000041);The authors would also like to thank for the IT resources made available by ReCaS(https://www.recas-bari.it/index.php/en/),a project funded by the MIUR(Italian Ministry for Education,University and Research)in the“PON Ricerca e Competitivita 2007-2013‐Azione I-Interventi di rafforzamento strutturale”PONa3_00052,Avviso 254/Ric,University of Bari.
Carnitine O-acetyltransferase(CRAT)is a crucial enzyme involved in mitochondrial energy metabolism.Alterations in CRAT activity have emerged as significant contributors to the pathogenesis of Leigh syndrome and relate...
关键词：carnitine acetyltransferase Leigh-like syndrome mitochondrial encephalomyopathy 3D modeling and virtual screening of chemical libraries SURAMIN ARTEMISININ 
Influence of Interspecies Interactions on Bacterial Community Assembly in the Active and Permafrost Layers on the Qinghai-Tibet Plateau
《Journal of Earth Science》2025年第2期395-407,共13页Hongfei Chi Xiufeng Yin Xuefeng Zhang Jingyi Zhu Lin Zhao Yongcui Deng Pengfei Liu Yongqin Liu 
supported by grants from the National Natural Science Foundation of China for Excellent Young Scientists Fund Program(No.42222105);the National Natural Science Foundation of China General Program(No.42171144);the Assessment of Ecosystem Carbon Stock and Turnover Patterns in Qinghai Province(No.2021-SFA7-1-1);the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(No.2021QZKK0100)。
Bacterial communities play a crucial role in permafrost biogeochemical cycling and ecosystem function maintenance.Bacterial interaction is one of the main factors in shaping soil bacterial communities.However,how woul...
关键词：PERMAFROST the Qinghai-Tibet Plateau bacterial community Interspecies interaction community assembly process biogeology 
Recent progress on understanding of micro-and electronicstructures to synergistically enable the activity and stability for oxygen reduction
《Nano Research》2025年第3期48-72,共25页Yao Liu Ruisi Li Junjun Xia Chenyang Shu Jianhong Liu Shaoxin Yan Rong Jin Haifeng Chen Liumei Teng Yujun Si Chaozhong Guo Yuxin Zhang Quan Xu 
financially supported by the National Natural Science Foundation of China(Nos.22478423 and 22275026);the Natural Science Foundation for Distinguished Young Scholars of Chongqing,China(No.CSTB2023NSCQJQX0032);the key project of Chongqing Science and Technology Bureau(No.CSTB2022TIAD-KPX0041).
Single-atom catalysts(SACs)are considered as the most promising nonprecious metal alternatives for oxygen reduction reactions(ORR)in proton exchange membrane fuel cells because of their high atomic utilization and exc...
关键词：single-atom catalysts(SACs) oxygen reduction reactions(ORR) structural regulation 
GnIH secreted by green light exposure,regulates bone mass through the activation of Gpr147
《Bone Research》2025年第1期212-223,共12页Yu You Konglin Huo Liang He Tongyue Wang Lei Zhao Rong Li Xiaoqing Cheng Xuebin Ma Zhiying Yue Stefan Siwko Ning Wang Lujian Liao Mingyao Liu Jian Luo 
National Key Research and Development Program of China(2023YFB3810200 to J.L.);National Natural Science Foundation of China(92168204,82225030 to J.L.);Fundamental Research Funds for the Central Universities(22120210586 to J.L.)。
Reproductive hormones associated with the hypothalamic-pituitary-gonadal(HPG)axis are closely linked to bone homeostasis.In this study,we demonstrate that Gonadotropin inhibitory hormone(GnIH,one of the key reproducti...
关键词：ACTIVATION HOMEOSTASIS GNIH 
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth
《Acta Pharmacologica Sinica》2025年第3期740-750,共11页Qing-yong Hu Lei Li Yu-huang Li Hai-bo Zhang Tao Deng Yang Liu Feng-tian Li Zhi-xiong Xiao Yang Cao 
supported by the National Natural Science Foundation of China(Grant numbers 81973243,81861148031,81520108020 and 31401130).
p53,a tumor suppressor protein,has a vital role in the regulation of the cell cycle,apoptosis,and DNA damage repair.The degradation of p53 is predominantly controlled by the murine double minute 2(MDM2)protein,a ubiqu...
关键词：MDM2 P53 virtual screening inhibitor 
Tianxiangdan(TXD) alleviates myocardial ischemia reperfusion-induced ferroptosis through the activation of estrogen receptor alpha(ERα)
《Chinese Journal of Natural Medicines》2025年第1期102-110,共9页Yuanjia Yue Yu Li Xing Rong Zhao Ji Huimin Wang Liang Chen Lin Jiang 
supported by the National Natural Science Foundation of China (No. 8196140154);the Natural Science Foundation of Xinjiang Uygur Autonomous Region (Nos.2023D01C139 and 2023D01C63);the State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia Fund (No. SKL-HIDCA-2020-8)。
Tianxiangdan(TXD),a traditional Chinese herbal remedy,demonstrates efficacy in mitigating myocardial ischemia-reperfusion(I/R)-induced damage.This study employed network pharmacology to evaluate the therapeutic target...
关键词：TIANXIANGDAN Estrogen receptor alpha Ferroptosis Myocardial ischemia-reperfusion injury Network pharmacology 
High-temperature calcination dramatically promotes the activity of Cs/Co/Ce-Sn catalyst for soot oxidation
《Chinese Chemical Letters》2025年第1期534-538,共5页Meng Wang Yan Zhang Yunbo Yu Wenpo Shan Hong He 
supported by the National Natural Science Foundation of China(Nos.22206183,52225004);the National Key R&D Program of China(No.2022YFC3701804);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA23010201);the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2022309)。
Catalytic oxidation of soot is of great importance for emission control on diesel vehicles.In this work,a highly active Cs/Co/Ce-Sn catalyst was investigated for soot oxidation,and it was unexpectedly found that high-...
关键词：Soot oxidation CALCINATION Surface defects Surface-active oxygen species NO_(2) 
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament
《Frontiers of Medicine》2024年第6期1087-1099,共13页Xiao Liu Lei Zhang Ge Wang Wei Zhao Chen Liang Youzhi Tang Yenan Fu Bo Liu Jing Zhang Xiaoguang Liu Hongquan Zhang Yu Yu 
supported by grants from the Ministry of Science and Technology of the People’s Republic of China(No.2022YFA1104003 to Hongquan Zhang and No.2021YFC2501003 to Hongquan Zhang);the National Natural Science Foundation of China(No.82073076 to Yu Yu,No.82372992 to Yu Yu,No.82230094 to Hongquan Zhang and No.81972616 to Hongquan Zhang,and No.82372451 to Xiaoguang Liu).
Ossification of the posterior longitudinal ligament(OPLL)is a condition comprising ectopic bone formation from spinal ligaments.This disease is a leading cause of myelopathy in the Asian population.However,the molecul...
关键词：OSSIFICATION posterior longitudinal ligament osteogenic differentiation IFN signaling 
Monocyte to high-density lipoprotein cholesterol ratio as a predictor of the activity of thyroid-associated ophthalmopathy
《International Journal of Ophthalmology(English edition)》2024年第12期2276-2281,共6页Xing-Hong Sun Xiao-Wen Zhang Chen Han Xin Dou Xue-Ying He Meng-Ru Su Feng Jiang Song-Tao Yuan 
Supported by the Special Fund for Clinical Research of Nanjing Drum Tower Hospital(No.2023-LCYJPY-37).
AIM:To evaluate the relationship between monocyte to high-density lipoprotein cholesterol ratio(MHR)and the disease activity of thyroid-associated ophthalmopathy(TAO).METHODS:A total of 87 patients were classified int...
关键词：thyroid-associated ophthalmopathy monocyte to high-density lipoprotein cholesterol ratio disease activity 
Effect of cobalt on the activity of nickel-based/magnesium-substituted hydroxyapatite catalysts for dry reforming of methane
《Chinese Journal of Chemical Engineering》2024年第12期281-291,共11页Tongming Su Bo Gong Xinling Xie Xuan Luo Zuzeng Qin Hongbing Ji 
supported by the Guangxi Natural Science Foundation(2020GXNSFDA297007);the National Natural Science Foundation of China(22078074);the Special Funding for‘Guangxi Bagui Scholars’.
The dry reforming of methane(DRM)reaction can directly convert methane(CH_(4))and carbon dioxide(CO_(2))into syngas(H_(2)+CO),which is a promising method for achieving carbon neutralization.In this study,a series of 3...
关键词：METHANE Carbon dioxide HYDROXYAPATITE Nickel COBALT 
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