supported by the National Key Research and Development Program of China(2021YFA1301900,2021YFA1301203 and 2022YFC2303700 to H.D.and Z.S.);the National Natural Science Foundation of China(31900039 and 32170029 to X.T.,81971974 to H.D.,32222040 and 32070049 to Z.S.);the 1.3.5 Project for Disciplines Excellence of West China Hospital,Sichuan University(ZYYC20021 to H.D.);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Action(TSBICIP-KJGG-008 to Z.S.).
CRISPR‒Cas7-11 is a Type Ⅲ-E CRISPR-associated nuclease that functions as a potent RNA editing tool.Tetratrico-peptide repeat fused with Cas/HEF1-associated signal transducer(TPR-CHAT)acts as a regulatory protein tha...