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3D printing of interferonγ-preconditioned NSC-derived exosomes/collagen/chitosan biological scaffolds for neurological recovery after TBI
《Bioactive Materials》2024年第9期375-391,共17页Chong Chen Zhe-Han Chang Bin Yao Xiao-Yin Liu Xiao-Wang Zhang Jun Liang Jing-Jing Wang Shuang-Qing Bao Meng-Meng Chen Ping Zhu Xiao-Hong Li 
supported by the National Key Research and Development Program of China(2021YFF1200800,2018YFA0108700);the National Natural Science Foundation of China(82171861,82170256,82101448);Guangdong Provincial Special Support Program for Prominent Talents(2021JC06Y656);Science and Technology Planning Project of Guangdong Province(2020B1111170011,2022B1212010010);Guangzhou Science and Technology Plan Project(202201000006);the Natural Science Foundation of Sichuan Province(24NSFSC3547).
The reconstruction of neural function and recovery of chronic damage following traumatic brain injury(TBI)remain significant clinical challenges.Exosomes derived from neural stem cells(NSCs)offer various benefits inTB...
关键词：EXOSOMES Traumatic brain injury Interferonγ 3D printing Neural reconstruction 
Tailoring therapeutics via a systematic beneficial elements comparison between photosynthetic bacteria-derived OMVs and extruded nanovesicles被引量：1
《Bioactive Materials》2024年第6期48-61,共14页Tingshan Xiao Yichuan Ma Ziyang Zhang Yixin Zhang Yu Zhao Xiaohan Zhou Xueyi Wang Kun Ge Junshu Guo Jinchao Zhang Zhenhua Li Huifang Liu 
supported by the National Natural Science Foundation of China(32322045,32271420,31971304,and 21977024);The Beijing-Tianjin-Hebei Basic Research Cooperation Project(19JCZDJC64100);Cross-Disciplinary Project of Hebei University(DXK201916);One Hundred Talent Project of Hebei Province(E2018100002);National High-End Foreign Expert Recruitment Plan(G2022003007L);Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province(B2021201038);Natural Science Foundation of Hebei Province(B2023201108);Hebei Province Higher Education Science and Technology Research Project(JZX2023001).
Photosynthetic bacteria(PSB)has shown significant potential as a drug or drug delivery system owing to their photothermal capabilities and antioxidant properties.Nevertheless,the actualization of their potential is im...
关键词：Photosynthetic bacteria Outer membrane vesicles Bacteria-derived nanovesicles ANTITUMOR LYSOPHOSPHATIDYLCHOLINE 
Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair被引量：3
《Bioactive Materials》2024年第5期242-258,共17页Zhaoping Wu Yi Zhou Xianglin Hou Weidong Liu Wen Yin Lei Wang Yudong Cao Zhipeng Jiang Youwei Guo Quan Chen Wen Xie Ziqiang Wang Ning Shi Yujun Liu Xiang Gao Longlong Luo Jianwu Dai Caiping Ren Xingjun Jiang 
supported by the National Natural Science Foundation of China(82071399);National Key Research and Development Program of China(2023YFC2412504,2016YFC1101502);Key Research and Development Program of Hunan Province(2021DK2003,2021SK2016).
Induced pluripotent stem cells(iPSCs)can be personalized and differentiated into neural stem cells(NSCs),thereby effectively providing a source of transplanted cells for spinal cord injury(SCI).To further improve the ...
关键词：Spinal cord injury Induced pluripotent stem cells LOCS Neural network tissue NEUROTROPHIN-3 
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts被引量：4
《Bioactive Materials》2024年第1期463-474,共12页Charles M.Kerr Sophia E.Silver Yi Sun Choi Martha E.Floy Amy D.Bradshaw Seung-Woo Cho Sean P.Palecek Ying Mei 
funded by the National Institutes of Health(NIH)F31 HL154665,R01 HL133308,8P20 GM103444,R21 HL167211,R01 HL168255,U01 HL169361,R01 HL148059;the NIH Cardiovascular Training Grant T32 HL007260;the National Science Foundation(NSF)(CBET-1743346),the NSF Engineering Research Center for Cell Manufacturing Technologies(CMaT,NSF EEC-1648035);the VA Merit I01 BX005943-01A1;supported by the grants,2021R1A2C3004262,2022M3A9B6082675,of the National Research Foundation of Korea(NRF)funded by the Korean government,the Ministry of Science and ICT(MSIT).
Human induced pluripotent stem cell derived cardiac fibroblasts(hiPSC-CFs)play a critical role in modeling human cardiovascular diseases in vitro.However,current culture substrates used for hiPSC-CF differentiation an...
关键词：Activated fibroblast Biomimetic substrate Extracellular matrix hiPSC-derived cardiac fibroblasts RNA sequencing 
Dual human iPSC-derived cardiac lineage cell-seeding extracellular matrix patches promote regeneration and long-term repair of infarcted hearts被引量：4
《Bioactive Materials》2023年第10期206-226,共21页Yun Jiang Ling-Ling Zhang Fan Zhang Wei Bi Peng Zhang Xiu-Jian Yu Sen-Le Rao Shi-Hui Wang Qiang Li Chen Ding Ying Jin Zhong-Min Liu Huang-Tian Yang 
Human pluripotent stem cell-derived cardiovascular progenitor cells (hCVPCs) and cardiomyocytes (hCMs) possess therapeutic potential for infarcted hearts;however, their efficacy needs to be enhanced. Here we tested th...
关键词：Induced human pluripotent stem cells Cardiac lineage cells Extracellular matrix patch Cardiomyocyte regeneration Infarcted heart repair 
Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity被引量：5
《Bioactive Materials》2023年第3期194-208,共15页Teng Ye Zhengsheng Chen Jieyuan Zhang Lei Luo Renzhi Gao Liangzhi Gong Yuhang Du Zongping Xie Bizeng Zhao Qing Li Yang Wang 
National Natural Science Foundation of China(Grant No.81870972,82072550);Science and Technology Commission of Shanghai Municipality(Grant No.21DZ2201300).
Tendinopathy is a common musculoskeletal disorder which results in chronic pain and reduced performance.The therapeutic effect of stem cell derived-small extracellular vesicles(sEVs)for tendinopathy has been validated...
关键词：Large extracellular vesicles iPSC-derived MSCs TENDINOPATHY Inflammatory regulation Macrophages 
iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel被引量：4
《Bioactive Materials》2022年第8期290-301,共12页Yoshifumi Kobayashi Julie Nouet Erdenechimeg Baljinnyam Zain Siddiqui Daniel HFine Diego Fraidenraich Vivek A.Kumar Emi Shimizu 
supported by NIH grants,R01DE025885(E.S),R15EY029504(VAK);National Science Foundation NSF IIP 1903617(VAK).
The dental pulp has irreplaceable roles in maintaining healthy teeth and its regeneration is a primary aim of regenerative endodontics.This study aimed to replicate the characteristics of dental pulp tissue by using c...
关键词：Regenerative endodontics IPSC Cranial neural crest Fibroblast growth factor Odontoblastic differentiation Angiogenic self-assembling peptide hydrogel 
Increased connectivity of hiPSC-derived neural networks in multiphase granular hydrogel scaffolds被引量：4
《Bioactive Materials》2022年第3期358-372,共15页Chia-Chen Hsu Julian H.George Sharlayne Waller Cyril Besnard David A Nagel Eric J Hill Michael D.Coleman Alexander M.Korsunsky Zhanfeng Cui Hua Ye 
This study was supported by funding from the Biotechnology and Biological Sciences Research Council(BB/H008527/1)(www.bbsrc.ac.uk);China Regenerative Medicine International(CRMI),Jiangsu Industrial Technology Research Institute(JITRI),and Engineering and Physical Sciences Research Council(EPSRC EP/P005381/1 and EP/V007785/1).
To reflect human development,it is critical to create a substrate that can support long-term cell survival,differentiation,and maturation.Hydrogels are promising materials for 3D cultures.However,a bulk structure cons...
关键词：MICROGEL HYDROGEL HYALURONAN IPSC Neural tissue engineering 3D printing 
Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration被引量：17
《Bioactive Materials》2021年第9期2754-2766,共13页Lei Fan Pengfei Guan Cairong Xiao Huiquan Wen Qiyou Wang Can Liu Yian Luo Limin Ma Guoxin Tan Peng Yu Lei Zhou Chengyun Ning 
This work was supported by the the National Natural Science Foundation of China(Nos.51932002,51903087,51772106,31771080);the Natural Science Foundation of Guangdong Province(No.2020A1515011369);the Science and Technology Program of Guangzhou(No.202002030308);the Science and Technology Innovation Team Project of Foshan(No.2018IT100101);Sino-Singapore International Joint Research Institute(No.203-A018004).
The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property.Bone marrow stem cells(BMSCs)derived exosomes(Exos)contain multiple biosignal molecules and have...
关键词：OSTEOIMMUNOLOGY Macrophages polarization POLYETHERETHERKETONE BMSC-Derived exosomes Bone regeneration 
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