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作品数：2085被引量：4671H指数：24
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Potential Mechanism of Huanglian Jiedu Decoction Regulating Iron Homeostasis in NLRP3/IFITM3/γ-secretase Pathway against AD Based on Network Pharmacology
《Medicinal Plant》2025年第2期35-39,共5页Ye CHU Yingyuan QIN Suyi CHEN Linhao LIU Mengjia LI Huanjin HUANG Liuyi WEI Yanyuan ZHOU Linglin CHEN Yifei CHEN 
Supported by National Natural Science Foundation of China(82160832);Natural Science Foundation of Guangxi Zhuang Autonomous Region(2022GXNSFAA035603&2017GXNSFAA198255);the Open Project Program of Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical University(GKLBCN-202206-02);the Fourth Training Plan of Thousands of Young and Mid-aged Mainstay Teachers in Guangxi Colleges and Universities.
[Objectives]To explore the possible targets of Huanglian Jiedu Decoction in NLRP3/IFITM3/γ-secretase pathway through regulating iron homeostasis and the potential mechanism of anti-Alzheimer s disease(AD).[Methods]Fi...
关键词：Huanglian Jiedu Decoction Iron homeostasis Action mechanism Alzheimer's disease(AD) Network pharmacology 
The protective effects of melatonin against electromagnetic waves of cell phones in animal models:A systematic review
《Animal Models and Experimental Medicine》2025年第4期629-637,共9页Mohammad Amiri Habibolah Khazaie Masoud Mohammadi 
Deputy for Research and Technology,Kermanshah University of Medical Sciences,Grant/Award Number:4030031。
Background:Due to the widespread use of cell phone devices today,numerous re-search studies have focused on the adverse effects of electromagnetic radiation on human neuropsychological and reproductive systems.In most...
关键词：animal model cell phone radiation MELATONIN 
Robust federated contrastive recommender system against targeted model poisoning attack
《Science China(Information Sciences)》2025年第4期46-61,共16页Wei YUAN Chaoqun YANG Liang QU Guanhua YE Quoc Viet Hung NGUYEN Hongzhi YIN 
supported by Australian Research Council under the Streams of Future Fellowship(Grant No.FT210100624);Discovery Project(Grant No.DP240101108);Linkage Project(Grant No.LP230200892)。
Federated recommender systems(FedRecs)have garnered increasing attention recently,thanks to their privacypreserving benefits.However,the decentralized and open characteristics of current FedRecs present at least two d...
关键词：federated recommender system contrastive learning model poisoning attack and defense 
Clearing the Air:A New Push Against Outdoor Secondhand Smoke
《Beijing Review》2025年第16期48-48,共1页
Strolling down a busy street,waiting in a parking lot or standing at the entrance of a scenic spot,many have encountered the sharp,unwelcome sting of cigarette smoke hanging heavily in the air.
关键词：parking lot outdoor smoke stinging smoke secondhand smoke cigarette smoke 
Potential inflammatory mechanisms of the ketogenic diet against febrile infection-related epilepsy syndrome
《Acta Epileptologica》2025年第1期11-21,共11页Juan Wang Lingling Xie Li Jiang 
supported by the Youth project of key Laboratory of Ministry of Education(3000971).
Febrile infection-related epilepsy syndrome(FIRES)is a rare epilepsy syndrome with unclear pathogenesis,characterized by fever-induced,super-refractory status epilepticus and high mortality.Studies have shown that ket...
关键词：Ketogenic diet Febrile infection-related epilepsy syndrome INFLAMMATION MECHANISMS 
Dendrobium officinale extract exerts antioxidant effects against skin photoaging through MMP9-TNF pathway
《Traditional Medicine Research》2025年第3期32-41,共10页Bei-Bei Dong Yun Wang Han Zhao Wu-Yan Guo Bo Zhang 
Background:Skin photoaging is a physiological or pathological process caused by multiple factors.Developing anti-skin photoaging drugs is a hot topic in cosmetology research fields.The purpose of this study was to exp...
关键词：Dendrobium officinale skin photoaging matrix metalloproteinase anti-oxidative stress 
Therapeutic potential of kakkatin derivatives against hepatocellular carcinoma
《World Journal of Clinical Oncology》2025年第3期13-19,共7页Sahiba Chahal Vikram Patial 
Supported by the Indian Council of Scientific and Industrial Research,No.MLP0204(CSIR-IHBT no.5712).
In this article,we commented on the work done by Jiang et al,where they syn-thesized a kakkatin derivative,6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-me-thoxy-4H-chromen-4-one(HK),and investigated its antitumor activ...
关键词：Hepatocellular carcinoma ANTITUMOR Kakkatin PROTOONCOGENES CISPLATIN 
Evaluation of bio-efficacy of Metarhizium anisopliae against the pink bollworm Pectinophora gossypiella(Saunders),with insights into its colonization potential and insecticide compatibility
《Journal of Cotton Research》2025年第1期76-88,共13页THAVKAR Snehal THUBE Shivaji PANCHBHAI Pramod LAVHE Nandkishor PILLAI Tinni SHAH Vivek DESHMUKH Vrushali PANDIAN Thavaprakasa R. FAND Babasaheb TENGURI Prabhulinga NIKOSHE Akash PRIYANK Mhatre BEHERE Gajanan PRASAD Yenumula 
Background The pink bollworm(Pectinophora gossypiella,PBW)is a major cotton pest,causing economic losses by damaging seeds and fiber.Cotton growers typically use systemic and broad-spectrum insecticides for its manage...
关键词：Bio-efficacy Compatibility Entomopathogenic fungi Metarhizium anisopliae Pink bollworm SEM 
GPR120/FFAR4 protects retinal vascular endothelial cells against high glucose injury via suppressing ROS-ERS mediated apoptosis
《International Journal of Ophthalmology(English edition)》2025年第3期383-389,共7页Li-Zhao Wang Jie-Jing Yan 
AIM:To evaluate the role of reactive oxygen speciesendoplasmic reticulum stress(ROS-ERS)in the cellular protection of G protein-coupled receptor 120(GPR120/FFAR4)against high glucose(HG)induced human retinal vascular ...
关键词：GPR120/FFAR4 high glucose APOPTOSIS oxidative stress retinal vascular endothelial cells 
Repurposing Diflunisal as an Antivirulence Agent Against Staphylococcus aureus
《Infectious Microbes & Diseases》2025年第1期43-53,共11页Daniel Sun Nina M.Haste Josh Sun Mateus SáMagalhães Serafim Anna Salvioni Joshua Olson Jason Cole Cheryl Okumura Richard L.Gallo George Sakoulas Anthony J.O’Donoghue Mary E.Hensler Victor Nizet 
supported by the US National Institutes of Health grants(R01-AI145325);This work was also supported in part by the UCSD Graduate Training Program in Cellular and Molecular Pharmacology through an institutional training grant from the National Institute of General Medical Sciences,T32 GM007752;The funder had no role in the study design,data collection or analysis,decision to publish,or preparation of the manuscript.MSMS acknowledges his PDE scholarship by CNPq(200069/2024-1).
Infections refractory to standard antibiotic therapy are contributing to adverse treatment outcomes in patients suffering from deep-seated bacterial infections caused by increasingly resistant pathogens.Adjunctive str...
关键词：Staphylococcus aureus DIFLUNISAL nonsteroidal anti-inflammatory drug drug repurposing antivirulence therapy antimicrobial peptides alpha-toxin BIOFILM 
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