ALTERNATIVE_SPLICING

作品数：214被引量：559H指数：10
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Splicing factor PTBP1 promotes hepatocarcinogenesis via oncogenic splice-switching of MAPT
《Oncology Research》2025年第5期1121-1133,共13页WENYING ZHENG YANYAN SHANG KAI DU AILING LUO LIJUN PEI MEIQI LI GUOPING ZHANG MIN DENG 
supported by the National Natural Science Foundation of China(Nos.81972771,82173062);the Key Areas Project of Education Department of Guangdong Province(No.2021ZDZX2017);the Tertiary Education Scientific Research Project of Guangzhou Municipal Education Bureau(No.202235387);the Guangzhou Science and Technology Project of Guangzhou Municipal Science and Technology Bureau(No.2023A03J0428);the Natural Science Foundation of Guangdong Province,China(No.2024A1515013082);the Guangdong Basic and Applied Basic Research 21 Foundation(No.2021A1515010403).
Background:Alterations in splicing factors contribute to aberrant alternative splicing(AS),which subsequently promotes tumor progression.The splicing factor polypyrimidine tract binding protein 1(PTBP1)has been shown ...
关键词：Hepatocellular carcinoma Alternative splicing PTBP1 MAPT 
The alternatively spliced diacylglycerol kinase gamma-Δexon13 transcript generated under hypoxia promotes glioblastoma progression
《Oncology Research》2025年第5期1189-1198,共10页MING YANG LIANGZHAO CHU SHUKAI LIN HAN PENG NIYA LONG KAYA XU HUA YANG FENG HAN JIAN LIU 
funded by Guizhou Province Science and Technology Plan Project Qiankehe Foundation-ZK[2023]General 360,362;Science and Technology Fund project of Guizhou Provincial Health Commission(gzwkj-2022-09,gzwkj-2023-035);National Natural Science Foundation Cultivation Project of Guizhou Medical University(21NSFCP14,gyfynsfc-2022-25);The PhD Scientific Research Launch Fund Project of the Affiliated Hospital of Guizhou Medical University(gyfybsky-2022-02).
Background:Glioblastoma(GBM)is one of the most malignant types of central nervous system tumors.Oxygen deprivation in the tumor microenvironment is thought to be an important factor in promoting GBM progression.Howeve...
关键词：Glioblastoma(GBM) HYPOXIA Diacylglycerol kinase gamma(DGKG) Alternative splicing 
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration
《Genes & Diseases》2025年第2期121-124,共4页Zhangxiang Zhao Yuquan Wang Zixin Jin Huiming Han Bo Chen Mingyue Liu Kaidong Liu Shuping Zhuang Haihai Liang Yunyan Gu 
supported by the National Key Research and Development Program of China (No.2023YFF1204600);the Guangdong Province Basic and Applied Basic Research Fund (China) (No.2022A1515110765);the National Natural Science Foundation of China (No.32270710);the Outstanding Youth Foundation of Heilongjiang Province of China (No.YQ2021H005).
Breast cancer,recognized as a foremost cause of mortality among women,is characterized by a complex immune microenvironment.Alternative splicing(AS)is a crucial process leading to diverse transcript variants.Studies h...
关键词：CANCER MORTALITY IMMUNE 
RNA-binding motif protein RBM39 enhances the proliferation of gastric cancer cells by facilitating an oncogenic splicing switch in MRPL33
《Acta Pharmacologica Sinica》2025年第4期1068-1081,共14页Cheng-piao Lu Jia-bin Li Dong-bao Li Yu-hong Wang Xiao-gang Jiang Jing-jing Ma Guoqiang Xu 
supported by the National Natural Science Foundation of China(32171437);the National Key R&D Program of China(2019YFA0802401);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB310017);Suzhou Science and Technology Development Project(SZM2023006);Gusu Key Health Talent Program of Suzhou(GSWS2022122);the Young Physician Scientists Program(ML42900323);Interdisciplinary Basic Frontier Innovation Program(YXY2302015)at Suzhou Medical College of Soochow University;the National Center for International Research(2017B01012);the Jiangsu Key Laboratory of Neuropsychiatric Diseases(BM2013003);a project funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
Gastric cancer is a malignant gastrointestinal disease characterized by high morbidity and mortality rates worldwide.The occurrence and progression of gastric cancer are influenced by various factors,including the abn...
关键词：RBM39 MRPL33 gastric cancer PROLIFERATION alternative splicing 
Extrachromosomal circular DNA and their roles in cancer progression
《Genes & Diseases》2025年第1期209-223,共15页Siqi Zheng Yunong Li Lin Wang Qian Wei Minjie Wei Tao Yu Lin Zhao 
supported by grants from the National Natural Science Foundation of China(No.82073281,8157346282073884,U20A20413);Shenyang S&T Projects(Liaoning,China)(No.20-204-4-22);Science and Technology Innovation Team Project of China Medical University(No.CXTD2022007);Supporting the High-Quality Development of Science and Technology Funding Projects at China Medical University(No.2022011963-JH2/202).
Extrachromosomal circular DNA(eccDNA),a chromosome-independent circular DNA,has garnered significant attention due to its widespread distribution and intricate biogenesis in carcinoma.Existing research findings propos...
关键词：Alternative splicing Cancer stem cell Extrachromosomal circle DNA Protein-protein interaction Tumor heterogeneity Tumor immune microenvironment 
Coupling of alternative splicing and alternative polyadenylation被引量：1
《Acta Biochimica et Biophysica Sinica》2025年第1期22-32,共11页Xueying Zhang Feiyan Liu Yu Zhou 
supported by the grants from the National Natural Science Foundation of China(No.82341023);the National Key R&D Program of China(No.2023YFC2307802);the Fundamental Research Funds for the Central Universities(No.2042022dx0003)to Y.Z.
RNA splicing and 3′-cleavage and polyadenylation(CPA)are essential processes for the maturation of RNA.There have been extensive independent studies of these regulated processing events,including alternative splicing...
关键词：alternative polyadenylation alternative splicing CROSSTALK RNA processing RNA regulation 
Alternative splicing drives the functional diversification of a b HLH transcription factor in the control of growth and drought tolerance in rice
《Science Bulletin》2025年第2期153-156,共4页Min Ning Qinyan Li Ya Wang Qingmao Li Yonghong Tao Fan Zhang Fengyi Hu Liyu Huang 
supported by the National Natural Science Foundation of China(32060474 and 32272079);the Yunnan Provincial Science and Technology Department(202101AS070001 and 202201BF070001-011);the Henan Academy of Agricultural Sciences Outstanding Youth Science and Technology Fund Project(2024JQ05);the Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-CSIAF-202303)。
Given the increase in global climate change,reconciling the increasing demand for food production with dwindling water resources poses a formidable challenge.To ensure sustainable rice production and global food secur...
关键词：DROUGHT mechanism tolerance 
METTL3-Mediated LINC00475 Alternative Splicing Promotes Glioma Progression by Inducing Mitochondrial Fission
《Research》2024年第4期348-364,共17页Yaping Yan Ailing Luo Shanshan Liu Mansi Cai Xiaodan Liu Xiaohong Zhang Siyi Zhang Yu Liu Jiamin Zeng Xinke Xu Na Zhang Zhuorong Zhang Yingyi Xu Jing He Xiaoping Liu 
supported by the National Natural Science Foundation of China(nos.81672496 and no.82173593);Guangzhou Municipal Science and Technology Bureau(nos.202201020603 and 202201020640);Guangzhou Municipal Science and Technology Program key projects(no.202206010006).
Mitochondrial fission promotes glioma progression.The function and regulation mechanisms of lncRNAs in glioma mitochondrial fission are unclear.The expression of LINC00475 and its correlation with clinical parameters ...
关键词：promoted thereby utilized 
Establishing a dominant early larval sex-selection strain in the Asian malaria vector Anopheles stephensi
《Infectious Diseases of Poverty》2024年第6期80-89,共10页Shih‑Che Weng Fangying Chen Ming Li Sammy Lee Connor Gerry Dylan Can Turksoy Omar S.Akbari 
supported by funding from NIH awards(R01AI151004,RO1AI148300,RO1AI175152)awarded to O.S.A.Figures were created using Prism9 for Windows(GraphPad Software,San Diego,USA)and www.BioRe nder.com.
Background Genetic biocontrol interventions targeting mosquito-borne diseases require the release of male mosquitoes exclusively,as only females consume blood and transmit pathogens.Releasing only males eliminates the...
关键词：Genetic sex sorting Malaria DOUBLESEX Sex-specific alternative splicing Anopheles stephensi Genetic biocontrol 
A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis
《Molecular Plant》2024年第12期1850-1865,共16页Michaela Králová Ivona Kubalová Jakub Hajný Karolina Kubiasová Karolína Vagaská Zengxiang Ge Michelle Gallei Hana Semerádová Anna Kuchařová Martin Hönig Aline Monzer Martin Kovačik JiříFriml Ondřej Novák Eva Benková Yoshihisa Ikeda David Zalabák 
Czech Science Foundation via project 23-07363S(to D.Z.,J.H.,K.V.,and O.N.);Scientific Service Units(SSU)of ISTA through resources provided by the Imaging and Optics Facility and the Life Science Facility.
Hormone perception and signaling pathways have a fundamental regulatory function in the physiological processes of plants.Cytokinins,a class of plant hormones,regulate cell division and meristem maintenance.The cytoki...
关键词：SPLICING ARABIDOPSIS DECOY 
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