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Reducing off-target effects of DdCBEs by reversing amino acid charge near DNA interaction sites: 《Cell Research》2024年第12期877-881,共5页Long Xie Yaqi Cao Di Li Mengxue Ma Danrong Jiao Hu Feng Zhenrui Zuo Erwei Zuo; Dear Editor,DddA_(tox)-derived cytosine base editors(DdCBEs)can mediate precise,CRISPR-independent editing of mitochondrial DNA(mtDNA),but were recently shown to potentially introduce extensive and non-trivial off-tar...; 关键词：TRIVIAL utilizing PRECISE

Amino acid availability governs mTOR ubiquitination: 《Cell Research》2024年第5期335-336,共2页Xiaoming Dai Peiqiang Yan Wenyi Wei; How mTORC1,a master regulator of cell growth,senses amino acid availability to regulate cell growth is an intriguing but mysterious question.In a recent paper published in Cell Metabolism,Ge et al.report that amino ac...; 关键词：mTORC1 depletion AVAILABILITY

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression被引量：258: 《Cell Research》2019年第10期787-803,共17页Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng; Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential m...; 关键词：inflammation ALZHEIMER SHAPED

DH44 neurons： gut-brain amino acid sensors被引量：1: 《Cell Research》2018年第11期1048-1049,共2页Yu-Chieh David Chen Anupama Dahanukar; Maintaining protein homeostasis is essential for the survival of animals. A recent study in Cell Research identifies a group of DH44＋ neuroendocrine cells in the Drosophila brain as a novel fast-acting amino acid sen...; 关键词：Molecular biology Nutrient signalling

A post-ingestive amino acid sensor promotes food consumption in Drosophila被引量：3: 《Cell Research》2018年第10期1013-1025,共13页Zhe Yang Rui Huang Xin Fu Gaohang Wang Wei Qi Decai Mao Zhaomei Shi Wei L. Shen Liming Wang; We thank all Wang Lab members for helpful discussions and technical assistance. We thank Pierre Leopold, Zhefeng Gong, Paul Taghert, Yi Rao, the Bloomington Drosophila stock center at Indiana University, and the Tsinghua Fly Center for fly stocks and reagents. We thank Zhaobing Gao and Yanfen Li （Shanghai Institute of Materia Medica） for their help with electrophysiological experiments. We thank Dr. Xiaoming Li and the Molecular Imaging Core Facility of School of Life Science and Technology, ShanghaiTech University for microscopic imaging. We thank members of the Neuroscience Pioneer Club for insightful discussions throughout the course of this study, and Yan Li, Xiaoke Chen, Liqun Luo and Dengke Ma for helpful comments on the manuscript. Danping Chen and Ye Wu provided scientific and administrative support in the laboratory. This study was funded by the National Natural Science Foundation of China （31522026 to L.W. and 31771169 to W.S.）, the Thousand Young Talents Plan （LW. and W.S.）, and the Fundamental Research Funds for the Central Universities （2016QN81010 and 2015XZZX004-33 to L.W.）.; Adequate protein intake is crucial for the sUrvival and well：being of animals. How animals assess prospective protein sources and ensure dietary amino acid intake plays a critical role in protein homeostasis. By usin...; 关键词：传感器识别食物消费氨基酸果蝇蛋白质来源基因激活 vivo 神经原

Multiple amino acid sensing inputs to mTORC1被引量：12: 《Cell Research》2016年第1期7-20,共14页itsugu Shimobayashi Michael N Hall; Acknowledgments We acknowledge support from the Louis-Jeantet Foundation, the Swiss National Science Foundation and the Canton of Basel.; The evolutionarily conserved target of rapamycin complex 1 （TORC1） is a master regulator of cell growth and metabolism. In mammals, growth factors and cellular energy stimulate mTORC1 activity through inhibition of ...; 关键词：mTORC1 amino acid RAG

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORCl被引量：23: 《Cell Research》2015年第12期1299-1313,共15页Carsten Gram Hansen Yuen Lam Dora Ng Wai-Ling Macrina Lam Steven W Plouffe Kun-Liang Guan; YAP and TAZ are transcriptional co-activators and function as the major effectors of the Hippo tumor suppressor pathway, which controls cell growth, tissue homeostasis, and organ size. Here we show that YAP/TAZ play a...; 关键词：HIPPO YAP MTOR LAT1/CD98 SLC7A5 amino acid

L_-glutamine provides acid resistance for Escherichia coil through enzymatic release of ammonia被引量：25: 《Cell Research》2013年第5期635-644,共10页Peilon Lu Dan Ma Yuling Chen Yingying Guo Guo-Qiang Chen Haiteng Deng Yigong Shi; Bacteria, exemplified by enteropathogenic Escherichia coli （E. coh）, rely on elaborate acid resistance systems to survive acidic environment （such as the stomach）. Comprehensive understanding of bacterial acid res...; 关键词：acid resistance bacterial stress response GLUTAMINASE GLUTAMINE amino acid antiporter

Leucyl-tRNA synthetase： double duty in amino acid sensing: 《Cell Research》2012年第10期1509-1509,共1页Rafil V Duran Michael N Hall; Due to a production error by the editorial office, this Research Highlight, which was originally published in the August issue of Cell Research （22：1207-1209. doi： 1 0.1038/cr.2012.68; published online 24 April 201...; 关键词：亮氨酰-TRNA合成酶氨基酸检测编辑部细胞复制

Leucyl-tRNA synthetase： double duty in amino acid sensing: 《Cell Research》2012年第9期1312-1314,共3页Raúl Durán Michael N Hall; The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Tw...; 关键词：亮氨酰-TRNA合成酶氨基酸检测哺乳动物细胞细胞反应分子水平亮氨酸 LRS

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