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A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy: 《Acta Pharmaceutica Sinica B》2024年第12期5407-5417,共11页Hongyu Wang Dengyuan Hao Qihang Wu Tingting Sun Zhigang Xie; supported by the National Natural Science Foundation of China(52003267 and 51973214);the Natural Science Foundation of Jilin Province(YDZJ202101ZYTS027,China).; Tumor microenvironment activatable therapeutic agents and their effective tumor accumula-tion are significant for selective tumor treatment.Herein,we provide an unadulterated nanomaterial combining the above advantage...; 关键词：Perylene diimide Morphological transformation Radical anion HYPOXIA TUMOR-SPECIFIC Photothermal therapy NANOFIBER Amino acid

Methylmalonic Acidemia: An Unusual Cause of Chronic Renal Disease in Adults: 《Open Journal of Nephrology》2024年第3期334-339,共6页Kamel El Reshaid Abdulrahman Al Kanderi; Background: Methylmalonic aciduria (MMA) is a genetic disorder of aminoacid metabolism, due to mutations in methylmalonyl-CoA mutase, which leads to the accumulation of methylmalonic acid in body fluids. Patients typi...; 关键词：Methylmalonic Acidemia Kidney Failure Metabolic Acidosis Autosomal Recessive Amino Acid Disorder Kreps Cycle Hyperammonia Vitamin 12 CARNITINE

Correction to:Amino acid-based enteral nutrition is effective for pediatric Crohn’s disease:a multicenter prospective study: 《Gastroenterology Report》2024年第1期872-872,共1页; This is a correction to:Qingfan Yang,Ting Zhang,Na Diao,Kang Chao,Huijun Shu,Jie Wu,Dexiu Guan,Li Wang,Xiwei Xu,Zhenghong Li,Xiang Gao,Amino acid-based enteral nutrition is effective for pediatric Crohn’s disease:a m...; 关键词：PEDIATRIC PROSPECTIVE CROHN

Taurine: a promising nutraceutic in the prevention of retinal degeneration被引量：2: 《Neural Regeneration Research》2024年第3期606-610,共5页Diego García-Ayuso Johnny Di Pierdomenico Ana Martínez-Vacas Manuel Vidal-Sanz Serge Picaud María PVillegas-Pérez; supported by Instituto de Salud CarlosⅢ(ISCⅢ):PI19/00203;cofunded by ERDF;"A way to make Europe"to MPVP and DGA;P122/00900;RD16/0008/0026 co-funded by ERDF;"A way to make Europe"to MPVP and RD21/0002/0014;financiado porla Unión Europea-NextGenerationEU;Fundación Robles Chillida to DGA;RED2018-102499-T;PID201 9-106498GB-I00;funded by MCIN/AEI/10.13039/501100011 033 to MVS;IHU FOReSIGHT[ANR-18-IAHU-0001] to SP; Taurine is considered a non-essential amino acid because it is synthesized by most mammals.However,dietary intake of taurine may be necessary to achieve the physiological levels required for the development,maintenanc...; 关键词：amino acid ANTI-INFLAMMATORY ANTIOXIDANT gamma-aminobutyric acid NUTRACEUTICAL photoreceptor degeneration RETINA retinitis pigmentosa TAURINE

Amino acid-based enteral nutrition is effective for pediatric Crohn’s disease:a multicenter prospective study被引量：1: 《Gastroenterology Report》2024年第1期3-10,共8页Qingfan Yang Ting Zhang Na Diao Kang Chao Huijun Shu Jie Wu Dexiu Guan Li Wang Xiwei Xu Zhenghong Li Xiang Gao; supported by the Guangdong Provincial Key Laboratory of Microecological Preparations[grant number 2022B1212020004];the Medical Scientific Research Foundation of Guangdong Province of China[grant number A2022099];the program of Guangdong Provincial Clinical Research Center for Digestive Diseases[grant number 2020B1111170004].; Background:Exclusive enteral nutrition(EEN)therapy effectively induces remission in pediatric Crohn’s disease(CD).However,this may depend on the type of enteral formula used.Moreover,data on the efficacy of amino aci...; 关键词：pediatric Crohn’s disease exclusive enteral nutrition amino acid-based enteral formula prospective study effectiveness nutrition improvement

New paradigm of oral rehydration in patients affected by irritable bowel syndrome with chronic diarrhea: 《World Journal of Gastrointestinal Pharmacology and Therapeutics》2024年第1期1-4,共4页Marco Chiarelli Matilde De Simone Gerardo Cioffi Ugo Cioffi; Irritable bowel syndrome with diarrhea is a very frequent clinical condition characterized by disabling intestinal symptoms.This disease presents with daily abdominal pain for at least 3 months related to defecation a...; 关键词：DIARRHEA Irritable bowel syndrome Diarrhea-predominant irritable bowel syndrome Medical food Amino acid beverage formulation

ATF4 renders human T-cell acute lymphoblastic leukemia cell resistance to FGFR1 inhibitors through amino acid metabolic reprogramming被引量：1: 《Acta Pharmacologica Sinica》2023年第11期2282-2295,共14页Zi-jian Zhang Qi-fang Wu An-qi Ren Qian Chen Jiang-zhou Shi Jia-peng Li Xi-yu Liu Zhi-jie Zhang Yu-zhe Tang Yuan Zhao Ning-ning Yao Xiao-yu Zhang Chang-peng Liu Ge Dong Jia-xuan Zhao Mei-jun Xu Yun-qiang Yue Jia Hu Fan Sun Yu Liu Qi-lin Ao Fu-ling Zhou Hong Wu Tong-cun Zhang Hai-chuan Zhu; funded by the grants from the Wuhan Science and Technology Plan Project(2019030703011533)to TCZ;China Postdoctoral Science Foundation(2021M702538);Department of Education of Hubei Province(B2021023);National Natural Science Foundation of China(82203497)to JPL;also supported by Natural Science Foundation of Hubei Province(2022CFB029);National Natural Science Foundation of China(82100193)to HCZ.; Abnormalities of FGFR1 have been reported in multiple malignancies, suggesting FGFR1 as a potential target for precision treatment, but drug resistance remains a formidable obstacle. In this study, we explored whether...; 关键词：T-ALL FGFR1 inhibitor AZD4547 PD-166866 drug resistance ATF4

A highly conserved amino acid in high molecular weight glutenin subunit 1Dy12 contributes to gluten functionality and processing quality in wheat被引量：1: 《Journal of Genetics and Genomics》2023年第11期909-912,共4页Changfeng Yang Qian Chen Mingming Xin Zhenqi Su Jinkun Du Weilong Guo Zhaorong Hu Jie Liu Huiru Peng Zhongfu Ni Qixin Sun Yingyin Yao; supported by the National Natural Science Foundation of China(32125030);Hainan Yazhou Bay Seed Lab(B21HJ0502);China Postdoctoral Science Foundation(2022M713413).; Bread wheat(Triticum aestivum L.)is one of the most commonly consumed staples worldwide,with widespread uses in foods such as breads,noodles,cakes,and cookies(Veraverbeke and Delcour,2002).The specific cooking propert...; 关键词：weight WHEAT GLUTEN

Effectiveness of an amino acid beverage formulation in diarrheapredominant irritable bowel syndrome:A pragmatic real-world study被引量：1: 《World Journal of Gastrointestinal Pharmacology and Therapeutics》2023年第5期39-49,共11页Samantha E Niles Phil Blazy Samuel N Cheuvront Robert W Kenefick Sadasivan Vidyasagar Adam BSmith Neil Fawkes William Denman; BACKGROUND Amino-acid based medical foods have shown promise in alleviating symptoms of drug induced gastrointestinal side effects;particularly,diarrhea-predominant symptoms.Irritable bowel syndrome(IBS)is a gastroint...; 关键词：Diarrhea-predominant irritable bowel syndrome Amino acid beverage formulation Pragmatic real-world study Medical food Bristol Stool Form Scale Irritable Bowel Syndrome–Severity Scoring System

Therapeutic poly(amino acid)s as drug carriers for cancer therapy: 《Chinese Chemical Letters》2023年第6期81-89,共9页Huihui Hu Zhen Zhang Yifen Fang Lei Chen Jun Wu; supported by the National Natural Science Foundation of China(Nos.51973243 and 52173150);the Shenzhen Basic Research Project(No.JCYJ20190807155801657);the International Cooperation and Exchange of the National Natural Science Foundation of China(No.51820105004)。; As one of the top global health problems,the effective treatment of cancer is one of the most urgent clinical challenges.Currently,the main treatments for cancer include surgery,chemotherapy,radiotherapy,and gene ther...; 关键词：Poly(amino acid)s IMMUNOMODULATORY ANTIOXIDANT ANTI-INFLAMMATORY Apoptosis-promoting

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