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BETA: 作品数：1050被引量：2083H指数：18; 导出分析报告; 相关领域：自动化与计算机技术医药卫生更多>>; 相关作者：凌凤香范峰赵震肖丰收段爱军更多>>; 相关机构：中国科学院北京大学山东大学中国石油化工股份有限公司更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划教育部人文社会科学研究基金更多>>

Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved被引量：3: 《Neural Regeneration Research》2019年第10期1661-1671,共11页Raquel Coronel Charlotte Palmer Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste; supported by grants from the Ministerio de Ciencia e Innovación-Instituto de Salud Carlos Ⅲ(PI-10/00291 and MPY1412/09);Ministerio de Economía y Competitividad(SAF2015-71140-R);Comunidad de Madrid(Neurostem-Comunidad de Madrid consortium; S2010/BMD-2336);supported by grants from Plan de Empleo Juvenil-Ministerio de Economía y Competitividad; The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of AP...; 关键词：AMYLOID precursor protein APP SOLUBLE APP alpha SOLUBLE APP BETA AMYLOID BETA peptide APP intracellular domain NEURAL stem CELLS NEURAL progenitor CELLS neurogenesis signaling pathways

Beta secretase activity in peripheral nerve regeneration被引量：4: 《Neural Regeneration Research》2017年第10期1565-1574,共10页Carolyn Tallon Mohamed H.Farah; supported by the Muscular Dystrophy Association and R01NS079339 from the National Institutes of Neurological Disease and Stroke of the National Institutes of Health; While the peripheral nervous system has the capacity to regenerate following a nerve injury,it is often at a slow rate and results in unsatisfactory recovery,leaving patients with reduced function.Many regeneration as...; 关键词：peripheral nerve axonal regeneration beta-site amyloid precursor protein-cleaving enzyme 1

The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus被引量：9: 《Neural Regeneration Research》2017年第10期1632-1639,共8页Bo Zhao Wen-wei Gao Ya-jing Liu Meng Jiang Lian Liu Quan Yuan Jia-bao Hou Zhong-yuan Xia; supported by the National Natural Science Foundation of China,No.81471844;the Natural Science Foundation of Hubei Province of China,No.2016CFB167;the Basic Scientific Research Foundation of Central Universities,No.2042017kf0147; Myocardial ischemia/reperfusion injury can lead to severe brain injury.Glycogen synthase kinase 3 beta is known to be involved in myocardial ischemia/reperfusion injury and diabetes mellitus.However,the precise role o...; 关键词：nerve regeneration myocardial ischemia/reperfusion injury brain injury glycogen synthase kinase 3 beta ischemic post-conditioning diabetes mellitus neural regeneration

Xuebijing alters tumor necrosis factor-alpha, interleukin-1beta and p38 mitogen activated protein kinase content in a rat model of cardiac arrest following cardiopulmonary resuscitation被引量：2: 《Neural Regeneration Research》2011年第33期2573-2576,共4页Haifeng Li Mingli Sun Yaxin Yu Xiaoliang Liu; a grant from the Science and Technology Department of Jilin Province,No. 200705172; We established a rat model of cardiac arrest by clamping the endotracheal tube of adult rats at expiration. Twenty-four hours after cardiopulmonary resuscitation, nerve cell injury and expression of tumor necrosis fac...; 关键词：cardiac arrest brain tumor necrosis factor-α INTERLEUKIN-1Β p38 mitogen activated protein kinase XUEBIJING cardiopulmonary resuscitation

SH2-B beta upregulates the expression of interleukin-1 beta in lung and visceral primary afferent neurons in asthmatic mice: 《Neural Regeneration Research》2011年第34期2703-2707,共5页Jinping Qi Xiaojie Wang Yun Jin; grant from the Liaoning Provincial Education Bureau, No. 20060890; A previous study by our research group showed that nerve growth factor is involved in the onset of asthma through regulating SH2-Bβ expression in the lung and visceral primary afferent neurons of asthmatic mice. This...; 关键词：SH2-BΒ INTERLEUKIN-1Β asthma primary afferent neurons spinal ganglia afferent nerve pathway

Inhibition of central sympathetic nervous tone improves cardiomyocyte contraction by increasing the response of beta 2-adrenergic receptor in aged rats: 《Neural Regeneration Research》2011年第14期1067-1071,共5页Ying Wang Zhi Zhao Qin Wu Yanling Hao Chuanying Xu Yiwei Sun Hong Sun Changdong Yan Dongye Li; the President Support Funding of Xuzhou Medical College,No.09KJZ31;the Social Development Program of Xuzhou,No.XM08C063; In the present study,selective β1-adrenergic receptor antagonist CGP20712A and selective β2-adrenergic receptor antagonist ICI 118551 were administered to isolated cardiomyocytes from young （4-6 months）,aged （18-...; 关键词：aging β-adrenergic receptor CONTRACTION sympathetic nervous system neural regeneration

Lithium chloride ameliorates learning and memory ability and inhibits glycogen synthase kinase-3 beta activity in a mouse model of fragile X syndrome被引量：3: 《Neural Regeneration Research》2011年第31期2452-2459,共8页Shengqiang Chen Xuegang Luo Quan Yang Weiwen Sun Kaiyi Cao Xi Chen Yueling Huang Lijun Dai Yonghong Yi; the National Natural Science Foundation of China,No.30870876;the Natural Science Foundation of Guangdong Province,No.815101700100005;the Science and Technology Program of Guangdong Province,No.2005B60302004,2008B030301371,2009B030801368;the Traditional Chinese Medicineand Combination of Traditional Chinese and Western Medicine Program of Guangzhou,No.2008A52;the Medical and Health Scientific Research Program of Guangzhou,No.2009-YB-167; In the present study,Fmr1 knockout mice （KO mice） were used as the model for fragile X syndrome.The results of step-through and step-down tests demonstrated that Fmr1 KO mice had shorter latencies and more error cou...; 关键词：fragile X syndrome Fmr1 knockout mice step-down test step-through test learning and memory glycogen synthase kinase 3 beta lithium chloride

1-methyl-4-phenylpyridinium ion induces endoplasmic reticulum stress through glycogen synthase kinase-3 beta activation in PC12 cells被引量：1: 《Neural Regeneration Research》2011年第11期805-810,共6页Shengdong Wang Fucheng Luo Yan Chen Lei Qi Jie Bai; the National Natural Science Foundation of China, No. 30860085;a grant from the Candidates of Young and Middle-Aged Academic Leaders of Yunnan Province, No. 2006PY01-07;the Natural Science Foundation of Yunnan Province, No. 2007C177M; 1-methyl-4-phenylpyridinium ion （MPP^＋） induces endoplasmic reticulum stress and activates caspase-12 in PC12 cells, leading to neuronal apoptosis. However, the underlying molecular mechanism remains unknown. The p...; 关键词：Parkinson＇s disease 1-methyl-4-phenylpyridinium ion endoplasmic reticulum stress glycogen synthase kinase-3β

Nicotine alpha 4 beta 2 receptor-mediated free calcium in an animal model of facial nucleus injury被引量：1: 《Neural Regeneration Research》2010年第19期1500-1504,共5页Dawei Sun Wenhai Sun Yanqing Wang Fugao Zhu Rui Zhou Yanjun Wang Banghua Liu Xiuming Wan Huamin Liu; Youth Research Fund of Qingdao University (2007); Previous studies have demonstrated that the cholinergic system, via nicotinic receptors, regulates intracellular free calcium levels in the facial nucleus under normal physiological conditions. However, the regulation...; 关键词：facial nerve injury nicotinic receptor CHOLINE CALCIUM peripheral nerve injury

Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rats: 《Neural Regeneration Research》2010年第5期353-357,共5页Xiaojuan Wang Hong Liu Liang Li; the Natural Science Foundation of Bei-jing, No. 7073088; BACKGROUND： Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer＇s disease, and β- and y-secretase play an important role in the generation of β-amyloid protein. ...; 关键词：chronic cerebral hypoperfusion Β-AMYLOID Β-SECRETASE Γ-SECRETASE Alzheimer＇s disease brain injury neural regeneration

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