BETA1

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Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist
《Neural Regeneration Research》2025年第10期2895-2897,共3页Nicolas Hugues Yu Luo 
supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...
关键词：FIGURE signature CRITICAL 
Emerging role of neuregulin-1beta1 in pathogenesis and progression of multiple sclerosis
《Neural Regeneration Research》2023年第1期133-134,共2页Seyyed Mohyeddin Ziaee Soheila Karimi-Abdolrezaee 
supported by a University of Manitoba Graduate Fellowship;Graduate Enhancement of Tricouncil Supplement (GETS);Hillary Kaufman Lerner Memorial Funds;supported by the grants from Multiple Sclerosis Society of Canada (EGDI-2936, EGDI-3742);the Canadian Institute of Health Research (133721 and 156218)
Multiple sclerosis(MS)is a chronic immune-mediated disorder of the central nervous system(CNS)that causes focal demyelinating lesions,followed by axonal and neuronal degeneration.Several genetic and environmental fact...
关键词：PATHOGENESIS SCLEROSIS DEGENERATION 
Congenital muscular dystrophy caused by beta1,3-Nacetylgalactosaminyltransferase 2 gene mutation:Two case reports被引量：1
《World Journal of Clinical Cases》2022年第3期1056-1066,共11页Wen-Juan Wu Su-Zhen Sun Bao-Guang Li 
BACKGROUND Mutations in the beta1,3-N-acetylgalactosaminyltransferase 2(B3GALNT2)gene can lead to impaired glycosylation ofα-dystroglycan,which,in turn,causes congenital muscular dystrophy(CMD).The clinical phenotype...
关键词：Beta1 3-N-acetylgalactosaminyltransferase 2 gene Congenital muscular dystrophy EPILEPSY Language development retardation AUTISM Case report 
Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression
《World Journal of Gastrointestinal Oncology》2021年第9期980-994,共15页Motomichi Fujita Hideo Suzuki Fumio Fukai 
Tenascin-C(TNC)is an adhesion modulatory protein present in the extracellular matrix that is highly expressed in several malignancies,including colon cancer.Although TNC is considered a negative prognostic factor for ...
关键词：TENASCIN-C TNIIIA2 Beta1-integrin Integrin activation Colitis-associated colorectal cancer Colon cancer 
Effects of epidermal growth factor on transforming growth factor-beta1-induced epithelial-mesenchymal transition and potential mechanism in human corneal epithelial cells被引量：2
《International Journal of Ophthalmology(English edition)》2020年第1期11-20,共10页Shu-Yang Chen Chen Xie Hong Zhu Ye Shen 
Supported by the 63th Postdoctoral Science Foundation of China(No.2018M632487);General Natural Science Projects;Department of Education,Zhejiang Province,China(No.Y201636718)
AIM: To evaluate the effects of epidermal growth factor(EGF) on transforming growth factor-beta1(TGF-β1)-induced epithelial-mesenchymal transition(EMT) in human corneal epithelial cells(HCECs). METHODS: HCECs were cu...
关键词：epidermal growth factor P38 epithelialmesenchymal transition corneal epithelial cell 
联合检测脑脊液MMP-9和TGF-β1在结核性脑膜炎、病毒性脑膜炎和细菌性脑膜炎早期鉴别诊断中的临床应用价值
《国际检验医学杂志》2019年第A01期194-197,共4页杨礼 张苏伟 林祥伟 
目的探讨脑脊液MMP-9和TGF-β1水平在结核性脑膜炎(TBM)、病毒性脑膜炎(VM)和细菌性脑膜炎(BM)中早期鉴别诊断的临床应用价值。方法2017年6月至2018年6月汕头市中心医院收治的脑膜炎患者共64例,其中TBM组16例,BM组26例:VM组22例。对照...
关键词：基质金属蛋白9 转化生长因子beta1 结核性脑膜炎 病毒性脑膜炎 细菌性脑膜炎 鉴别诊断 
穴位贴敷对过敏性鼻炎大鼠炎性反应的调节作用被引量：14
《针刺研究》2019年第6期430-433,共4页陈姗 金禹彤 朱正阳 吴凌韬 宣丽华 
浙江省重大科技专项计划资助项目(No.2014C03046-2)
目的:观察穴位贴敷对过敏性鼻炎(AR)大鼠血清免疫球蛋白E(IgE)、转化生长因子beta 1(TGF-β1)和鼻黏膜嗜酸性粒细胞(EOS)的影响,探讨穴位贴敷对AR的作用机制。方法:Wistar大鼠随机分为正常对照组、模型组、药物组和穴贴组,每组10只。采...
关键词：穴位贴敷 过敏性鼻炎 转化生长因子beta1 炎性反应调节 
Wulong Xiaozheng Wan medicated serum inhibits epithelial-mesenchymal transition in human gastric carcinoma cell line BGC823 by modulation of transforming growth factor-β1/Smad signaling被引量：3
《Journal of Traditional Chinese Medicine》2019年第3期380-392,共13页Zhang Yali Wang Bingyu Guo Xueying Yang Lei Li Dandan Yuan Xingxing 
Supported by State Administration of Traditional Chinese Medicine Science and Technology Research Projects(Chinese pharmaceutical 2016ZX05);Effect of Wulong Xiaozheng Wan on Intermediate Gastric Carcinoma and its Mechanism
OBJECTIVE:To evaluate the effect of Wulong Xiaozheng Wan medicated serum on the epithelial-mesenchymal transition (EMT) of BGC823 cell induced by transforming growth factor-β,(TGF-β,) and to explore its mechanism.ME...
关键词：Transforming growth factor BETA1 Smad proteins Signal transduction Epithelial-mesenchymal transition Matrix metalloproteinases secreted BGC823 cell WULONG Xiaozheng WAN 
Effect of Sini decoction on angiotensin Ⅱ, transforming growth factor β_1 and connective tissue growth factor in rats with myocardial fibrosis-induced banding of the abdominal aorta被引量：1
《Journal of Traditional Chinese Medicine》2018年第3期427-432,共6页Shi Yueping Zhai Jianli Liu Chunxiao 
Supported by Liaoning Province Nature Science Foundation project:The Mechanic of Wenyangtongmai Method on Myocardial Injury Rats(No.201102128)
OBJECTIVE: To investigate the effect of Sini decoction on rats with myocardial fibrosis induced by banding the abdominal aorta, and explore the mechanism underlying its actions on angiotensin Ⅱ(Ang Ⅱ), transforming ...
关键词：Myocardial fibrosis ANGIOTENSIN Ⅱ Transforming GROWTH FACTOR BETA1 CONNECTIVE tis-sue GROWTH FACTOR Sini decoction 
姜黄素对血管紧张素Ⅱ刺激大鼠肾小管上皮细胞TGF-β1及smad7表达的影响被引量：4
《国际中医中药杂志》2017年第1期39-42,共4页王玉霞 王芳 申绯翡 崔华胜 王慧敏 
目的：观察姜黄素对血管紧张素Ⅱ（angiotensinⅡ, AngⅡ）刺激大鼠肾小管上皮细胞TGF-β1及smad7表达的影响，探讨姜黄素改善肾间质纤维化的作用机制。方法培养大鼠肾小管上皮细胞，按随机数字表法分为空白组，AngⅡ对照组，姜黄素低...
关键词：姜黄素 血管紧张素Ⅱ 上皮细胞 肾间质纤维化 转化生长因子beta1 smad7蛋白质 
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