The commonly used antimitotic chemotherapeutic agents such as taxol and vinblastine arrest cell cycle progression by disrupting mitotic spindles, and cause cancer cells to undergo apoptosis through 'mitotic catastro...
The 66 kDa estrogen receptor alpha (ERa66) is the main molecular target for endocrine therapy such as tamoxi- fen treatment. However, many patients develop resistance with unclear mechanisms. In a large cohort study...
DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chro- mosomal instabilities or gene mutations. Here we report a new class of self-inflicted DNA DSBs that can...
Autophagy is activated to maintain cellular energy homeostasis in response to nutrient starvation. However, au- tophagy is not persistently activated, which is poorly understood at a mechanistic level. Here, we report...
Oncogenic mutations in RAS genes are very common in human cancer, resulting in cells with well-characterized selective advantages, but also less well-understood vulnerabilities. We have carried out a large-scale loss-...
Many cancer cells depend on glutamine as a fuel for proliferation, yet the mechanisms by which glutamine supports cancer metabolism are not fully understood. Two recent studies highlight an important role for glutamin...
Dear Editor, Nanosized particulate systems combining better cancer diagnosis with therapeutic effect are being designed based on the merging of nanotechnology with cellular and molecular techniques. The surface of the...
Epithelial-mesenchymal transition (EMT) in cancer describes the phenotypic and behavioral changes of cancer cells from indolent to virulent forms with increased migratory, invasive and metastatic potential. EMT can ...
supported by the National Nature Science Foundation of China(No.30070183,No.30470398);Key Subject Foundation of Shanghai Municipal Education Committee(No.B9808010).
It is well documented that the glycosylation of E-cadherin is correlated with cancer metastasis, but whether E- cadherin could be core fucosylated remains largely unknown. We found that E-cadherin was core fucosylated...
Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line. The objective of this study was to investigate if the antipr...