CANCER_CELLS

作品数:433被引量:1403H指数:15
导出分析报告
相关作者:苏文金陈玉强吴乔游波彭波更多>>
相关机构:南通大学中山大学东南大学厦门大学更多>>
相关期刊:更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>
-

检索结果分析

结果分析中...
选择条件:
  • 期刊=Cell Researchx
条 记 录,以下是1-10
视图:
排序:
Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells被引量:7
《Cell Research》2018年第5期544-555,共12页Chen Qi Xin Wang Zhirong Shen She Chen Hong Yu Noelle Williams Gelin Wang 
The commonly used antimitotic chemotherapeutic agents such as taxol and vinblastine arrest cell cycle progression by disrupting mitotic spindles, and cause cancer cells to undergo apoptosis through 'mitotic catastro...
关键词:APOPTOSIS 有丝分裂 死亡受体 房间 癌症 激活 TAXOL 代理人 
Tamoxifen enhances stemness and promotes metastasis of ERa36 breast cancer by upregulating ALDHIA1 in cancer cells被引量:7
《Cell Research》2018年第3期336-358,共23页Qiang Wang1' 2, Jun Jiang3, Guoguang Ying4, Xiao-Qing Xiel' 2, Xia Zhang1' 2 Wei Xul' 2, 5 Xuemin Zhang6, Erwei Song7, Hong Bun, Yi-Fang Ping1' 2, Xiao-Hong Yao1' 2, Bin Wang1' 2, Shilei Xu4, Ze-Xuan Yan1' 2, Yanhong Tai9, Baoquan Hu3, Xiaowei Qi3, Yan-Xia Wangl' 2, Zhi-Cheng He1' 2, Yan Wang1' 2, Ji Ming Wang, You-Hong Cui1' 2, Feng ChenI2, Kun Meng12, Zhaoyi Wang1' 2, 13, Xiu-Wu Bian1' 2 
The 66 kDa estrogen receptor alpha (ERa66) is the main molecular target for endocrine therapy such as tamoxi- fen treatment. However, many patients develop resistance with unclear mechanisms. In a large cohort study...
关键词:breast cancer estrogen receptor cancer stem cells METASTASIS endocrine therapy 
Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells被引量:3
《Cell Research》2017年第6期764-783,共20页Liu, Xinjian Li, Fang Huang, Qian Zhang, Zhengxiang Zhou, Ling Deng, Yu Zhou, Min Fleenor, Donald E. Wang, He Kastan, Michael B. Li, Chuan-Yuan 
DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chro- mosomal instabilities or gene mutations. Here we report a new class of self-inflicted DNA DSBs that can...
关键词:sublethal caspase activation spontaneous DNA double-strand breaks DNA damage response ATM activation cancer stem cells 
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells被引量:8
《Cell Research》2013年第4期491-507,共17页Ying Zhao Xue Li Mu-Yan Cai Ke Ma Jing Yang Jingyi Zhou Wan Fu Fu-Zheng Wei Lina Wang Dan Xie Wei-Guo Zhu 
Autophagy is activated to maintain cellular energy homeostasis in response to nutrient starvation. However, au- tophagy is not persistently activated, which is poorly understood at a mechanistic level. Here, we report...
关键词:FoxO 1 XBP- 1 u ERK AUTOPHAGY cancer 
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies被引量:5
《Cell Research》2012年第8期1227-1245,共19页Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock 
Oncogenic mutations in RAS genes are very common in human cancer, resulting in cells with well-characterized selective advantages, but also less well-understood vulnerabilities. We have carried out a large-scale loss-...
关键词:KRAS synthetic lethal oncogene addiction PROTEASOME TOPOISOMERASE 
Breathless cancer cells get fat on glutamine被引量:2
《Cell Research》2012年第3期443-446,共4页Dimitrios Anastasiou Lewis C Cantley 
Many cancer cells depend on glutamine as a fuel for proliferation, yet the mechanisms by which glutamine supports cancer metabolism are not fully understood. Two recent studies highlight an important role for glutamin...
关键词:谷氨酰胺 癌细胞 脂肪 气喘 新陈代谢 癌症治疗 不完全 
Ag nanoparticles sensitize IR-induced killing of cancer cells被引量:12
《Cell Research》2009年第8期1031-1034,共4页Ruizhi Xu Jun Ma Xinchen Sun ZhongpingChen Xiaoli Jiang Zhirui auo Lan Huang YangLi Meng Wang Changling Wang Jiwei Liu XuFan Jiayu Gu Xi Chen Yu Zhang Ning Gu 
Dear Editor, Nanosized particulate systems combining better cancer diagnosis with therapeutic effect are being designed based on the merging of nanotechnology with cellular and molecular techniques. The surface of the...
关键词:银纳米粒子 癌细胞 诱导 敏感 红外 细胞融合技术 生物分子 载体表面 
Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells被引量:6
《Cell Research》2008年第8期858-870,共13页Valerie A Odero-Marah Ruoxiang Wang Gina Chu Majd Zayzafoon Jianchun Xu Chunmeng Shi Fray F Marshall Haiyen E Zhau Leland WK Chung 
Epithelial-mesenchymal transition (EMT) in cancer describes the phenotypic and behavioral changes of cancer cells from indolent to virulent forms with increased migratory, invasive and metastatic potential. EMT can ...
关键词:EMT bone microenvironment RANKL prostate cancer bone metastasis EGF TGFΒ1 SNAIL 
The expression of core fucosylated E-cadherin in cancer cells and lung cancer patients: prognostic implications被引量:19
《Cell Research》2004年第5期423-433,共11页FeiGENG BiZhiSHI YunFengYUAN XingZhongWU 
supported by the National Nature Science Foundation of China(No.30070183,No.30470398);Key Subject Foundation of Shanghai Municipal Education Committee(No.B9808010).
It is well documented that the glycosylation of E-cadherin is correlated with cancer metastasis, but whether E- cadherin could be core fucosylated remains largely unknown. We found that E-cadherin was core fucosylated...
关键词:Core fucosylated E-cadherin PROGNOSIS cancer metastasis RNA interference molecular modeling. 
Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells被引量:29
《Cell Research》2004年第3期188-196,共9页Cecile CORBIERE Bertrand LIAGRE Faraj TERRO Jean-Louis BENEYTOUT 
Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line. The objective of this study was to investigate if the antipr...
关键词:DIOSGENIN apoptosis P53 AIF CASPASE cancer cells. 
检索报告 对象比较 聚类工具 使用帮助 返回顶部