CHOLESTASIS

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Granulocyte colony-stimulating factor reduces biliary fibrosis and ductular reaction in a mouse model of chronic cholestasis
《Liver Research》2023年第1期90-98,共9页Trinh Van Le Thanh Minh Dang Huy Quang Do Ai-Xuan Le Holterman Hong-Thuy Phan-Thi Thong Tan Tran Nhung Hai Truong 
funded by the Prometheus USA(www.prometheususa.org)and Vietnam National Foundation for Science&Technology Development(NAFOSTED)under grant number 108.05e2017.30.
Background:Biliary atresia is a rare congenital bile duct disease that is the leading cause of liver fibrosis in neonates.Granulocyte colony-stimulating factor(GCSF)is a potential therapy for hepatocellular diseases,b...
关键词：Bile duct ligation(BDL) Biliary fibrosis Ductular reaction Granulocyte colony-stimulating factor(GCSF) Hepatic stellate cell(HSC) 
Prediction of effective percutaneous transhepatic biliary drainage in patients with hepatocellular carcinoma: A multi-central retrospective study被引量：1
《Liver Research》2022年第4期269-275,共7页Haofan Wang Yitao Mao Chunning Zhang Xiaojun Hu Bin Chen Luwen Mu Shuyi Wang Yifen Lin Zhanwang Xiang Mingsheng Huang 
This study was funded by National Natural Science Foundation of China (81701847 to Y.Mao);Natural Science Foundation of Hunan Province (2017JJ3497 to Y.Mao)。
Background and aim:Percutaneous transhepatic biliary drainage(PTBD)does not always lead to a reduction in serum total bilirubin(TBil)level in patients with hepatocellular carcinoma and obstructive jaundice.We aimed to...
关键词：Hepatocellular carcinoma(HCC) Percutaneous transhepatic biliary drainage (PTBD) CHOLESTASIS BILIRUBIN Platelet count NOMOGRAMS Predictive model 
Recent insights into the pathogeneses and therapeutic targets of liver diseases: Summary of the 4th Chinese American liver Society/Society of Chinese Bioscientists in America Hepatology Division Symposium in 2021被引量：2
《Liver Research》2022年第1期50-57,共8页Wen-Xing Ding Hua Wang Yuxia Zhang On behalf of the Chinese American Liver Society Symposium Organizing Committee 
The 4th Chinese American Liver Society(CALS)/Society of Chinese Bioscientists in America(SCBA)Hepatology Division Annual Symposium was held virtually on October 29e30,2021.The goal of the CALS Symposium was to present...
关键词：Liver diseases Alcohol-related liver disease(ALD) CHOLESTASIS Drug-induced liver injury(DILI) Hepatocellular carcinoma(HCC) Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) SYMPOSIUM 
Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function被引量：3
《Liver Research》2021年第3期171-180,共10页Mohammad Mehdi Ommati Hamidreza Mohammadi Khadijeh Mousavi Negar Azarpira Omid Farshad Reyhaneh Dehghani Asma Najibi Sedigheh Kamran Hossein Niknahad Reza Heidari 
This work was financially supported by the Vice-Chancellor of Research Affairs of Shiraz University of Medical Sciences,Shiraz,Iran(Grant No.19444).
Background and aim:Cholestasis-associated renal injury or cholemic nephropathy(CN)is a serious clinical problem.Previous studies mentioned that oxidative stress and mitochondrial impairment play a role in CN.There is ...
关键词：METFORMIN Bile acids CHOLESTASIS CIRRHOSIS Oxidative stress Mitochondrial function Energy crisis Cholemic nephropathy(CN) Renal failure 
Mitigation of cholestasis-associated hepatic and renal injury by edaravone treatment: Evaluation of its effects on oxidative stress and mitochondrial function被引量：2
《Liver Research》2021年第3期181-193,共13页Mohammad Mehdi Ommati Hanie Attari Asma Siavashpour Marzieh Shafaghat Negar Azarpira Hasti Ghaffari Leila Moezi Reza Heidari 
This study was financially supported by the Vice-Chancellor of Research Affairs of Shiraz University of Medical Sciences(Grant number:97-01-36-18730);Shanxi Agricultural University(Grant numbers:2018YJ33 and K271999031 for National Natural Science Foundation of China and Outstanding Doctors Volunteering to Work in Shanxi Province,respectively).
Background and aim:The liver is the primary organ affected by cholestasis,and complications such as renal injury,renal failure,and the need for renal transplantation are associated with cholestatic liver disease.There...
关键词：Bile acids CHOLESTASIS CIRRHOSIS NEPHROPATHY Oxidative stress Renal failure 
Functional roles of gut bacteria imbalance in cholangiopathies被引量：1
《Liver Research》2019年第1期40-45,共6页Keisaku Sato Fanyin Meng Giammarco Fava Shannon Glaser Gianfranco Alpini 
This work was supported in part by the Dr.Nicholas C.High-tower Centennial Chair of Gastroenterology from Scott&White,a Veterans Health Administration Research Career Scientist award(IK6BX004601);a VA Merit award to Dr.G.Alpini(5I01BX000574);a VA Merit Award(1I01BX001724)to Dr.F.Meng from the United States Department of Veterans Affairs Biomedical Laboratory Research;the USA National Institutes of Health(NIH)grants DK110035,DK054811,DK062975,DK115184,AA025997 and AA025157 to Drs.G.Alpini,F.Meng and S.Glaser.
Cholangiopathies are caused by bile duct damage or inflammation followed by cholestasis leading to liver fibrosis.Bile duct epithelial cells,cholangiocytes,are a primary target for cholangiopathies.Ductular reaction i...
关键词：Cholangiopathies Bile acids Gut bacteria CHOLANGIOCYTES CHOLESTASIS INFLAMMATION 
Primary sclerosing cholangitis:A review and update被引量：5
《Liver Research》2017年第4期221-230,共10页James H.Tabibian Christopher L.Bowlus 
This work was supported by US NIH grant R21DK100897(to Dr.C.L.Bowlus).
Primary sclerosing cholangitis(PSC)is a rare,chronic,cholestatic liver disease of uncertain etiology characterized biochemically by cholestasis and histologically and cholangiographically by fibroobliterative inflamma...
关键词：Bile duct diseases Primary sclerosing cholangitis(PSC) CHOLESTASIS CHOLANGIOCARCINOMA Magnetic resonance imaging Cholangiography Natural history 
Transgenic overexpression of steroid sulfatase alleviates cholestasis
《Liver Research》2017年第1期63-69,共7页Mengxi Jiang Meishu Xu Songrong Ren Kyle W.Selcer Wen Xie 
This work was supported in part by the National Institutes of Health grants DK083952 and HD073070(to W.X.).
Background and Aim:Sulfotransferase(SULT)-mediated sulfation and steroid sulfatase(STS)-mediated desulfation represent two critical mechanisms that regulate the chemical and functional homeostasis of endogenous and ex...
关键词：Steroid sulfatase Bile acid TOXICITY CHOLESTASIS Liver X receptor 
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