Transgenic mice overexpressing the 770-amino acid isoform of human Alzheimeramyloid precursor protein exhibit extracellular β-amyloid deposits in brain regions including cerebral cortex and hippocampus, which are sev...
As an important biological phenomenon, circadian rhythm has been studied extensively, but the rhythms of receptors have received the attention only in recent years. The presence of diurnal rhythm has been reported for...
It is generally accepted that the parasympathetic preganglionic neurons are cholinergic. However, in our laboratory it has been observed that the acetylcholinesterase (ACHE) positive neurons could not be seen in the a...
Anisodamine is newly isolated from Chinese medicinal herbs and synthesized first in China. Anisodamine, showing an inhibitory effect on cholinergic nerve function as well as an improvement of microcirculation, are ext...
Several studies have shown that acetylcholine (ACh) is an excitatory transmitter in the anuran optic tectum; the nucleus isthmus (NI) is an important source of tectal cholinergic activity; an d acetylcholinesterase (A...
In order to explore the anti-shock mechanisms of anisodamine (654-2), an anti-cholinergic agent, which has been successfully used for the therapy of shock, particularly septic, the effects of intravenous administratio...