CHOLINERGIC

作品数：112被引量：321H指数：9
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相关机构：北京大学首都医科大学附属北京朝阳医院中国医学科学院北京协和医学院中国中医研究院更多>>
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Cholinergic dysfunction-induced insufficient activation of alpha7 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3/PAD4 pathway
《Acta Pharmaceutica Sinica B》2023年第4期1600-1615,共16页Changjun Lv Minghui Sun Yilei Guo Wenxin Xia Simiao Qiao Yu Tao Yulai Fang Qin Zhang Yanrong Zhu Yusufu Yalikun Yufeng Xia Zhifeng Wei Yue Dai 
supported by the“Double First-Class”University Project(CPU2022QZ31,China)。
Both cholinergic dysfunction and protein citrullination are the hallmarks of rheumatoid arthritis(RA),but the relationship between the two phenomena remains unclear.We explored whether and how cholinergic dysfunction ...
关键词：Rheumatoid arthritis CITRULLINATION Cholinergic dysfunction a7nAChR Peptidylarginine deiminase 4 Specificity protein-3 Collagen-induced arthritis Neuron-macrophage coculture system 
Kai Xin San ameliorates scopolamine-induced cognitive dysfunction被引量：13
《Neural Regeneration Research》2019年第5期794-804,共11页Yu-Min Xu Xin-Chen Wang Ting-Ting Xu Hong-Ying Li Shang-Yan Hei Na-Chuan Luo Hong Wang Wei Zhao Shu-Huan Fang Yun-Bo Chen Li Guan Yong-Qi Fang Shi-Jie Zhang Qi Wang Wei-Xiong Liang 
supported by the National Natural Science Foundation of China,No.81473740,81673627,81673717(to QW);Guangzhou Science Technology and Innovation Commission Technology Research Projects,China,No.2018050100(to QW);the Foundation for Characteristic Innovation of Educational Commission of Guangdong Province,China,Grant No.2016KTSCX011(to SHF);the Open Tending Project for Construction of High-Level University,Guangzhou University of Chinese Medicine,China,No.34 and 118,2017(to SHF);the Technology Platform of Clinical Trials on New Traditional Medicine,China,No.2012ZX09303009-003(to WXL);the Technology Platform of Clinical Evaluation on New Traditional Medicine,China,No.2008ZX09312-021(to WXL)
Kai Xin San(KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this s...
关键词：Kai Xin SAN cognitive DYSFUNCTION SCOPOLAMINE hydrobromide neuroprotection oxidative stress SYNAPTIC DYSFUNCTION apoptosis CHOLINERGIC system DYSFUNCTION DONEPEZIL neural regeneration 
Accelerating Alzheimer’s pathogenesis by GRK5 deficiency via cholinergic dysfunction
《Advances in Alzheimer's Disease》2013年第4期148-160,共13页William Z. Suo 
G protein-coupled receptors (GPCRs) mediate a wide variety of physiological function. GPCR signaling is negatively regulated by the receptor desensitization, a procedure initiated by a group of kinases, including GPCR...
关键词：G Protein Receptor KINASE CHOLINERGIC ALZHEIMER PATHOGENESIS 
Effect of Kangshuai Yizhi Formula Ⅰ (抗衰益智方Ⅰ) on Learning and Memory Dysfunction Induced by Scopolamine in Mice被引量：1
《Chinese Journal of Integrative Medicine》2010年第3期252-257,共6页韦佳 陆大祥 戚仁斌 王华东 江雪华 
Supported by Special Fund for Doctor Discipline Research of Ministry of Education(No.20060559003);Key Programs for Science and Technology Development of Guangzhou (2008J1-C181)
Objective：To evaluate the improvement of Kangshuai Yizhi FormulaⅠ（抗衰益智方Ⅰ,KYFⅠ）on the learning and memory dysfunction in mice,and on the mechanism of the hippocampal cholinergic system and the nervous system...
关键词：dysmnesic CHOLINERGIC monoamine neurotransmitters monoamine oxidase 
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