COLORECTAL

作品数：1242被引量：5539H指数：26
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  • 期刊=Signal Transduction and Targeted Therapyx
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Alternating modified CAPOX/CAPIRI plus bevacizumab in untreated unresectable metastatic colorectal cancer:a phase 2 trial
《Signal Transduction and Targeted Therapy》2025年第1期321-327,共7页Sheng Li Xiaoyou Li Hanfeng Xu Jiayuan Huang Jingni Zhu Ying Peng Jun Bao Liangjun Zhu 
supported by Beijing Science and Technology Innovation Medical Development Foundation(grant no.KC2021-JX-0186-106).
Previous studies showed encouraging efficacy of alternating FOLFOX/FOLFIRI for metastatic colorectal cancer(mCRC).This phase 2 trial(NCT04324476)aimed to evaluate efficacy and safety of alternating modified CAPOX(cape...
关键词：BEVACIZUMAB UNTREATED COLORECTAL 
Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy
《Signal Transduction and Targeted Therapy》2024年第11期5237-5249,共13页Liuqing Yang Ye Yang Jing Zhang Minghui Li Long Yang Xing Wang Meifang Chen Hua Zhang Bing He Xueqing Wang Wenbing Dai Yiguang Wang Qiang Zhang 
supported by the National Natural Science Foundation of China(U20A20412,81821004,U22A20384,82225044,52273136);National Key R&D Program of China(2022YFC3501900,2023YFC2605004);Beijing Natural Science Foundation(L222127,L212013);AI+Health Collaborative Innovation Cultivation Project(Z211100003521002).
PROteolysis TArgeting Chimeras(PROTACs)have been considered the next blockbuster therapies.However,due to their inherent limitations,the efficacy of PROTACs is frequently impaired by limited tissue penetration and par...
关键词：IMPAIRED PRECISE treatment 
Signaling pathways involved in colorectal cancer:pathogenesis and targeted therapy
《Signal Transduction and Targeted Therapy》2024年第11期4856-4903,共48页Qing Li Shan Geng Hao Luo Wei Wang Ya-Qi Mo Qing Luo Lu Wang Guan-Bin Song Jian-Peng Sheng Bo Xu 
supported by the National Natural Science Foundation of China(82203066,to Q.L.);the Chongqing Natural Science Foundation(2024NSCQMSX3327,to Q.L.);the National Natural Science Foundation of China(61906022,to B.X.);Chongqing University Research Fund 2021CDJXKJC004.
Colorectal cancer(CRC)remains one of the leading causes of cancer-related mortality worldwide.Its complexity is influenced by various signal transduction networks that govern cellular proliferation,survival,differenti...
关键词：PATHOGENESIS TARGETED COLORECTAL 
Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期2999-3014,共16页Yun Yang Qingya Liu Meng Wang Lang Li Yan Yu Meng Pan Danrong Hu Bingyang Chu Ying Qu Zhiyong Qian 
supported by the National Natural Science Foundation of China(NSFC82202320,NSFC31930067,and NSFC U21A2041);the Natural Science Foundation of Sichuan Province(2023NSFSC1585);the 135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD18002,China);the Post-Doctor Research Project,West China Hospital,Sichuan University(No.19HXBH099,China).
Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens,including prolonged circulation in the bloodstream,specific cell recognition and targeting...
关键词：CD47 COLORECTAL cancer 
Unveiling the culprit:the fusobacterium lineage that populates colorectal cancer
《Signal Transduction and Targeted Therapy》2024年第6期2349-2350,共2页Johannes Betge Matthias P.Ebert 
supported by the Hector Ⅱ Foundation.
In a recent study published in Nature,Zepeda-Rivera et al.1 discovered that one distinct clade of Fusobacterium nucleatum animalis(Fna)dominates the colorectal cancer(CRC)tumor niche.The work unravels a more precise u...
关键词：COLORECTAL al. CANCER 
Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy
《Signal Transduction and Targeted Therapy》2024年第5期2091-2103,共13页Ri-Xin Chen Shui-Dan Xu Min-Hua Deng Shi-Hui Hao Jie-Wei Chen Xiao-Dan Ma Wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang 
This work was supported by grants from the National Natural Science Foundation of China(No.82203715,81972227);the NSFC Incubation Project of GDPH(No.KY012021157,KY0120220052).The authors appreciate Dr.Zi-Hao Feng(Sun Yat-sen University,Guangzhou,China)for conducting bioinformatic analysis.
RNA-binding proteins(RBPs)-RNA networks have contributed to cancer development.Circular RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer...
关键词：COLORECTAL INHIBITING MPP 
Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal lcancergrowth
《Signal Transduction and Targeted Therapy》2023年第10期5119-5119,共1页Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu Zhenwei Li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min Liu Mingliang Ye De-an Guo Xiaochi Ma 
In the process of collating the raw data,the authors noticed an inadvertent mistake occurred in Fig.3b that needs to be corrected after online publication of the article.In Fig.3b,as a result of an error in the graphi...
关键词：COLORECTAL GRAPHICS arrangement 
Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme被引量：1
《Signal Transduction and Targeted Therapy》2023年第8期3837-3848,共12页Xinyue Wang Qian Chen Yefei Zhu Kairuo Wang Yongliang Chang Xiawei Wu Weichao Bao Tongcheng Cao Hangrong Chen Yang Zhang Huanlong Qin 
This article was supported by the National Natural Science Foundation of China(Grant Nos.81730102,32271384);Shanghai Basic Research Program(Grant No.20JC1411702);Shanghai Science and Technology Program(Grant No.20ZR1456100);Basic Study on Public Projects in Zhejiang Province(Grant No.LGF20H060017);the National Key Research and Development Program of China(Grant No.2021YFB3801001);China Postdoctoral Science Foundation(Grant No.2021M702484);Shanghai Post-doctoral Excellence Program(Grant No.2020382);Shanghai General Hospital Integrated Traditional Chinese and Western Medicine Special Project(Grant No.ZHYY-ZXYJHZX-202105).The authors would like to thank the workers from Shiyanjia Lab(www.shiyanjia.com)for tests of XANES and EXAFS.
The crucial role of intratumoral bacteria in the progression of cancer has been gradually recognized with the development of sequencing technology.Several intratumoral bacteria which have been identified as pathogens ...
关键词：COLORECTAL ELEVATED CATALYTIC 
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1被引量：15
《Signal Transduction and Targeted Therapy》2023年第3期1159-1174,共16页Heng Xu Hongfang Zhao Chunyong Ding Defang Jiang Zijie Zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang 
We are grateful to National Centre for Protein Science Shanghai for their instrument support and technical assistance.We thank the staffs from BL19U1 beamline of National Facility for Protein Science Shanghai(NFPS)at Shanghai Synchrotron Radiation Facility,for assistance during data collection.We gratefully acknowledge the financial supports from the National Key Research and Development Program of China(2020YFE0202200 to H.Z.and 2021ZD0203900 to C.L.);the project of National Multidisciplinary Innovation Team of Traditional Chinese Medicine(ZYYCXTD-202004 to C.L.);the National Natural Science Foundation of China(81903538 to H.Z.,82104064 to H.X.,91853205 to C.L.,91853206 to G.C.,81773565 to A.Z.,81972615 to Y.X.,and 21877120,22177068 to C.D.);the Postdoctoral Research Foundation of China(2019M661673 to H.Z.);the Shanghai Sailing Plan(19YF1457200 to H.Z.);the grants from Shanghai Jiao Tong University(AF1700037,WF220217002,WH101117001,and WF540162618 to A.Z.).
As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor activities.The clinical application of Celastrol is strictly...
关键词：COLORECTAL cancer NUDE 
Circulating tumor DNA analysis:potential to revise adjuvant therapy for stage II colorectal cancer
《Signal Transduction and Targeted Therapy》2022年第10期3613-3615,共3页Ning Zhu Hanguang Hu Ying Yuan 
supported by the Provincial Key R&D Program of Zhejiang Province(2021C03125 to Y.Y.);the National Natural Science Foundation of China(81872481 to Y.Y.)。
In the DYNAMIC multicenter phase 2 study recently published in The New England Journal of Medicine,Tie J.et al.demonstrated that a novel circulating tumor DNA(ctDNA)-guided regimen reduced the use of adjuvant chemothe...
关键词：ADJUVANT COLORECTAL al. 
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