COLORECTAL_CANCER

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  • 期刊=Signal Transduction and Targeted Therapyx
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Signaling pathways involved in colorectal cancer:pathogenesis and targeted therapy
《Signal Transduction and Targeted Therapy》2024年第11期4856-4903,共48页Qing Li Shan Geng Hao Luo Wei Wang Ya-Qi Mo Qing Luo Lu Wang Guan-Bin Song Jian-Peng Sheng Bo Xu 
supported by the National Natural Science Foundation of China(82203066,to Q.L.);the Chongqing Natural Science Foundation(2024NSCQMSX3327,to Q.L.);the National Natural Science Foundation of China(61906022,to B.X.);Chongqing University Research Fund 2021CDJXKJC004.
Colorectal cancer(CRC)remains one of the leading causes of cancer-related mortality worldwide.Its complexity is influenced by various signal transduction networks that govern cellular proliferation,survival,differenti...
关键词：PATHOGENESIS TARGETED COLORECTAL 
Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期2999-3014,共16页Yun Yang Qingya Liu Meng Wang Lang Li Yan Yu Meng Pan Danrong Hu Bingyang Chu Ying Qu Zhiyong Qian 
supported by the National Natural Science Foundation of China(NSFC82202320,NSFC31930067,and NSFC U21A2041);the Natural Science Foundation of Sichuan Province(2023NSFSC1585);the 135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD18002,China);the Post-Doctor Research Project,West China Hospital,Sichuan University(No.19HXBH099,China).
Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens,including prolonged circulation in the bloodstream,specific cell recognition and targeting...
关键词：CD47 COLORECTAL cancer 
Unveiling the culprit:the fusobacterium lineage that populates colorectal cancer
《Signal Transduction and Targeted Therapy》2024年第6期2349-2350,共2页Johannes Betge Matthias P.Ebert 
supported by the Hector Ⅱ Foundation.
In a recent study published in Nature,Zepeda-Rivera et al.1 discovered that one distinct clade of Fusobacterium nucleatum animalis(Fna)dominates the colorectal cancer(CRC)tumor niche.The work unravels a more precise u...
关键词：COLORECTAL al. CANCER 
Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期2091-2103,共13页Ri-Xin Chen Shui-Dan Xu Min-Hua Deng Shi-Hui Hao Jie-Wei Chen Xiao-Dan Ma Wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang 
This work was supported by grants from the National Natural Science Foundation of China(No.82203715,81972227);the NSFC Incubation Project of GDPH(No.KY012021157,KY0120220052).The authors appreciate Dr.Zi-Hao Feng(Sun Yat-sen University,Guangzhou,China)for conducting bioinformatic analysis.
RNA-binding proteins(RBPs)-RNA networks have contributed to cancer development.Circular RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer...
关键词：COLORECTAL INHIBITING MPP 
A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal被引量：3
《Signal Transduction and Targeted Therapy》2023年第9期4403-4415,共13页Min Luo Xueping Wang Shaocong Wu Chuan Yang Qiao Su Lamei Huang Kai Fu Sainan An Fachao Xie Kenneth Kin Wah To Fang Wang Liwu Fu 
National Natural Science Foundation of China(U21A20421);National Natural Science Foundation of China(82073882);National Natural Science Foundation of China(82203649);Guangdong Basic and Applied Basic Research Foundation(2020B1515120032);China Postdoctoral Science Foundation(2021M693648);Guangdong Esophageal Cancer Institute Science and Technology Program(M202001).
Immune checkpoint inhibitors(ICIs)have induced durable clinical responses in a subset of patients with colorectal cancer(CRC).However,the dis-satisfactory response rate and the lack of appropriate biomarkers for selec...
关键词：STC1 GSK3Β A20 
FBXW7βloss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth被引量：6
《Signal Transduction and Targeted Therapy》2023年第6期3123-3143,共21页Wenxia Wei Baifu Qin Weijie Wen Boyu Zhang Haidan Luo Yuzhi Wang Hui Xu Xiaoshan Xie Sicheng Liu Xin Jiang Mengan Wang Qin Tang Jiayu Zhang Runxiang Yang Zongmin Fan Haiwen Lyu Junzhong Lin Kai Li Mong-Hong Lee 
supported by National Key R&D Program of China(2020YFA0803300),the Basic and Applied Basic Research Program of Guangzhou City(202102020084);the Basic and Applied Basic Research Program of Guangdong Province(2023A1515030245),the Natural Science Foundation of Guangdong Province(2021A1515012081);the National Natural Science Foundation of China(81630072);the Guangzhou Science and Technology Program Project(202206010167).
Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor.FBXW7 is a highly mutated gene in CRC,but its biological functions in cancer are not fully characterized.Here,we report that FB...
关键词：FBXW7 SUSTAINED FASN 
Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis被引量：2
《Signal Transduction and Targeted Therapy》2023年第4期1357-1360,共4页Xuyang Yang Yaguang Zhang Yang Zhang Huifang Li Li Li Yangping Wu Xiangzheng Chen Lei Qiu Junhong Han Ziqiang Wang 
the Department of Science and Technology of Sichuan Province(2019YFS0375;2021YFS0025;2022YFS0162);1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(20HXJS003;ZYGD18003);1·3·5 project for disciplines of excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University(22HXFH001,2019HXFH031);a Post-Doctoral Research Project,West China Hospital,Sichuan University(2021HXBH033);a Post-Doctoral Research Project,Sichuan University(20826041E4084);the China Postdoctoral Science Foundation(2022M712264);the National Natural Science Foundation of China(82103541).
Dear Editor,To date,the effect of colorectal cancer(CRC)-derived extracellular vesicles(EVs)on liver pre-metastatic niche(PMN)remain incompletely understood.1 To investigate the role of CRC-derived EVs in the remodeli...
关键词：metastasis METASTATIC cancer 
Circulating tumor DNA analysis:potential to revise adjuvant therapy for stage II colorectal cancer
《Signal Transduction and Targeted Therapy》2022年第10期3613-3615,共3页Ning Zhu Hanguang Hu Ying Yuan 
supported by the Provincial Key R&D Program of Zhejiang Province(2021C03125 to Y.Y.);the National Natural Science Foundation of China(81872481 to Y.Y.)。
In the DYNAMIC multicenter phase 2 study recently published in The New England Journal of Medicine,Tie J.et al.demonstrated that a novel circulating tumor DNA(ctDNA)-guided regimen reduced the use of adjuvant chemothe...
关键词：ADJUVANT COLORECTAL al. 
DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2被引量：8
《Signal Transduction and Targeted Therapy》2022年第9期3536-3550,共15页Gang Zhao Hang Yuan Qin Li Jie Zhang Yafei Guo Tianyu Feng Rui Gu Deqiong Ou Siqi Li Kai Li Ping Lin 
This work was supported by the National Natural Science Foundation of China(81874071,81773756,82103525,and 82072933);1.3.5 project for disciplines of ecellence-Clinical Research Incubation Project,West China Hospital,Sichuan University(2020HXFH007);Post-Doctor Research Project,West China Hospital,Sichuan University(2020HXBH036).
Metastasis is a major cause of colorectal cancer(CRC)mortality,but its molecular mechanisms are still not fully understood.Here,we show that upregulated DDX39B correlates with liver metastases and aggressive phenotype...
关键词：PKM2 COLORECTAL INVASION 
Ketogenic diet:new avenues to overcome colorectal cancer
《Signal Transduction and Targeted Therapy》2022年第9期3145-3146,共2页Yuancai Xiang Meng Wang Hongming Miao 
This work was supported by the award number 82173134(M.H.)from the National Natural Science Foundation of China.
In a recent article published in Nature,Dmitrieva-Posocco et al.1showed that ketogenic diets(KD)exert strong abilities to prevent and treat colorectal cancer(CRC)via the ketone bodyβ-hydroxybutyrate(BHB)-mediated hyd...
关键词：COLORECTAL al. CANCER 
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