This research was partially funded by the National Key R&D program of China(2018YFA0508200 to ZFL);Clinical Innovations of Shanghai SHENKANG(SHDC12019112 to DLW);the Strategic Priority Research Program of Chinese Academy of Sciences(XDB19000000 and XDA12010318 to ZFL);the National Natural Science Foundation of China(81672526 to DLW and 81872075 to JJT);the Prostate Cancer Foundation Young Investigator Award(#15YOUN11 to ZFL).
Dear Editor,Abiraterone has achieved great success in clinic by targeting cytochrome P45017A1(CYP17A)for prostate cancer therapy.1,2 However,drug resistance is inevitable and novel strategy is urgently required.Our pr...
Breast cancer,which bears high incidence and mortality rate,is the most commonly diagnosed cancer in the female around the world.Approximately 70%of breast cancer cases express estrogen receptor.17a-hydroxylase/17,20-...
supported by the Chinese Agriculture Research System (No. CARS-47);Shandong Provincial Natural Science Foundation (No. ZR2016CQ21);the Key Laboratory of Mariculture (Ocean University of China), Ministry of Education (No. 2018008)
In this study, three cDNA sequences corresponding to cytochrome P450 C17(CYP17 Ⅰ), 3β-hydroxysteroid dehydrogenase(3β-HSD) and androgen receptor(AR) were isolated from spotted sea bass(Lateolabrax maculatus). The m...