DEGENERATION

作品数：521被引量：1030H指数：13
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相关机构：上海中医药大学复旦大学青岛大学华中科技大学更多>>
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A pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells
《Signal Transduction and Targeted Therapy》2024年第6期2679-2693,共15页Junzhi Yi Hui Zhang Fangyuan Bao Zhichu Chen Yuliang Zhong Tianning Ye Xuri Chen Jingyi Qian Mengya Tian Min Zhu Zhi Peng Zongyou Pan Jianyou Li Zihao Hu Weiliang Shen Jiaqi Xu Xianzhu Zhang Youzhi Cai Mengjie Wu Hua Liu Jing Zhou Hongwei Ouyang 
supported by the National Natural Sciences Foundation of China(Nos.T2121004,82394441,92268203);Zhejiang Provincial Natural Science Foundation of China(No.LTGY23H060009);pre-research Fund project of Huzhou Central Hospital Affiliated&Zhejiang University School of Basic Medicine.
The knee joint has long been considered a closed system.The pathological effects of joint diseases on distant organs have not been investigated.Herein,our clinical data showed that post-traumatic joint damage,combined...
关键词：DEGENERATION damage inhibited 
Astrocytes in human central nervous system diseases: a frontier for new therapies被引量：5
《Signal Transduction and Targeted Therapy》2023年第11期5233-5269,共37页Alexei Verkhratsky Arthur Butt Baoman Li Peter Illes Robert Zorec Alexey Semyanov Yong Tang Michael V.Sofroniew 
grants from NSFC-RSF(82261138557);the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202003);the Sichuan Science and Technology Program(2022YFH0006);Y.T.was supported by NSFC(82274668,82230127);Sichuan Provincial Administration of Traditional Chinese Medicine(2023zd024).Work in the M.V.S.laboratory is supported by National Institutes of Health(NS084030);by the Dr.Miriam and Sheldon G.Adelson Medical Foundation.
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system(CNS).Astroglia contribute to the pathophysiology of all neurological and neuropsych...
关键词：DISEASES EPILEPSY DEGENERATION 
Metabolic landscape in cardiac aging:insights into molecular biology and therapeutic implications被引量：8
《Signal Transduction and Targeted Therapy》2023年第4期1610-1629,共20页Saiyang Xie Si-Chi Xu Wei Deng Qizhu Tang 
the National Key R&D Program of China(2018YFC1311300);the National Natural Science Foundation of China(No:82170245,81860080,and 82070204);The Regional Innovation and Development Joint Fund of National Natural Science Foundation of China(No.U22A20269).
Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure.The metabolic microenvironment has been identified as a hallmark of malignancy,but recent studies have shed light on ...
关键词：CARDIAC DEGENERATION INVOLVEMENT 
Mutation-independent gene knock-in therapy targeting 5′UTR for autosomal dominant retinitis pigmentosa
《Signal Transduction and Targeted Therapy》2023年第4期1361-1363,共3页Duc Anh Hoang Baoshan Liao Zongli Zheng Wenjun Xiong 
(Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences)for their help and reagents on in vitro CRISPR/CAS9 screening.This research was funded by Research Grants Council Hong Kong Project 11103819,Hong Kong Health and Medical Research Fund Project 06172466,TUNG Biomedical Sciences Foundation,and Ming Wai Lau Center(MWLC)Associate Member Programme to W.X.
Dear Editor,Retinitis pigmentosa(RP)is an inherited photoreceptor degeneration disease with high genetic heterogeneity(>90 disease-causing genes according to RetNet:https://web.sph.uth.edu/RetNet/sumdis.htm).Taking a ...
关键词：autosomal DEGENERATION IDENTIFIER 
Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization
《Signal Transduction and Targeted Therapy》2023年第3期905-907,共3页Shao-bin Wang Yosuke Nagasaka Dionne Argyle Ayami Nagasaka Praveen Yerramothu Bradley DGelfand Jayakrishna Ambati 
J.A.has received support from the UVA Strategic Investment Fund,National Institutes of Health(NIH)grants(R01EY028027,R01EY029799,R01EY031039,R01AG082108);DuPont Guerry,III,Professorship,and a gift from Mr.and Mrs.Eli W.Tullis,S.B.W has received support from Annette Lightner Fund(Annette Lightner Research Award),B.D.G.has received support from NIH grants(R01EY028027,R01EY031039,R01EY032512,R01AG082108);BrightFocus Foundation Award M2020114,and the Owens Family Foundation.
Dear Editor,Vascular endothelial growth factor-A(VEGFA,also known as VEGF)is a critical angiogenic factor that regulates the physiological and pathological blood vessel growth.1 Increased abundance of VEGF in the eye ...
关键词：DEGENERATION OCULAR RELEASE 
Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration被引量：7
《Signal Transduction and Targeted Therapy》2023年第3期1186-1197,共12页Kaiqin She Yi Liu Qinyu Zhao Xiu Jin Yiliu Yang Jing Su Ruiting Li Li Song Jianlu Xiao Shaohua Yao Fang Lu Yuquan Wei Yang Yang 
This work was supported by the National Natural Science Foundation of China(nos.U19A2002,82222030 and 82201212).
The prime editor(PE)can edit genomes with almost any intended changes,including all 12 possible types of base substitutions,small insertions and deletions,and their combinations,without the requirement for double stra...
关键词：EDITOR DEGENERATION precise 
Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer’s:treatment perspectives for Alzheimer’s
《Signal Transduction and Targeted Therapy》2021年第12期3369-3370,共2页Natja Haag Hans Zempel 
This research was funded by the Else-Kröner-Fresenius Stiftung(2019_A41);the Jürgen-Manchot-Stiftung and was supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne(assigned to HZ);a START-grant from the RWTH/University Hospital Aachen assigned to NH.
In their new paper,McAlpine and colleagues provide compelling evidence that astrocyte dependent microglial stimulation is crucial for fighting off one of the most prominent Alzheimer disease(AD)pathological hallmarks,...
关键词：STIMULATION ALZHEIMER DEGENERATION 
Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-βinduced retinal pigmented epithelium degeneration被引量：1
《Signal Transduction and Targeted Therapy》2021年第5期1526-1534,共9页Siddharth Narendran Felipe Pereira Praveen Yerramothu Ivana Apicella Shao-bin Wang Kameshwari Ambati Shuichiro Hirahara Younghee Kim Meenakshi Ambati Vidya L.Ambati Peirong Huang Akhil Varshney Yosuke Nagasaka Shinichi Fukuda Kirstie L.Baker Kenneth M.Marion Jan M.Deussing Srinivas R.Sadda Bradley D.Gelfand Jayakrishna Ambati 
J.A.has received support from NIH grants(R01EY028027,R01EY29799,R01EY031039);DuPont Guerry,III,Professorship,a gift from Mr.and Mrs.Eli W.Tullis,and the University of Virginia Strategic Investment Fund;B.D.G.has received support from NIH grants(R01EY028027 and R01EY031039);BrightFocus Foundation,and the Owens Family Foundation.
Nonfibrillar amyloid-βoligomers(AβOs)are a major component of drusen,the sub-retinal pigmented epithelium(RPE)extracellular deposits characteristic of age-related macular degeneration(AMD),a common cause of global b...
关键词：DEGENERATION ACTIVATION UPSTREAM 
Intercellular mitochondrial transfer as a means of tissue revitalization被引量：11
《Signal Transduction and Targeted Therapy》2021年第3期705-722,共18页Delin Liu Youshui Gao Jiao Liu Yigang Huang Junhui Yin Yuyao Feng Linjing Shi Bruno PMeloni Changqing Zhang Minghao Zheng Junjie Gao 
supported by the grants from National Natural Science Foundation of China(Nos.81820108020 and 81672143);Shanghai Pujiang Program(No.2020PJD039);the fund from China Scholarship Council.
As the crucial powerhouse for cell metabolism and tissue survival,the mitochondrion frequently undergoes morphological or positional changes when responding to various stresses and energy demands.In addition to intrac...
关键词：METABOLISM HOMEOSTASIS DEGENERATION 
D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration被引量：4
《Signal Transduction and Targeted Therapy》2020年第1期2280-2291,共12页Bowen Wang Li Wang Sijie Gu Yankun Yu Huaxing Huang Kunlun Mo He Xu Fanzhu Zeng Yichen Xiao Lulu Peng Chunqiao Liu Nan Cao Yizhi Liu Jin Yuan Hong Ouyang 
The National Key Research and Development(R&D)Program of China(2016YFA0101700);National Natural Science Foundation of China(81700805,81622012 and 81870633);Fundamental Research Funds for the Central Universities(17ykjc28);Fundamental Research Funds of the State Key Laboratory of Ophthalmology.Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06S029).
Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium(RPE)cell death,which is considered to be the primary cause of dry age-related macular degeneration(AMD),leading to blindness in the el...
关键词：D609 DEGENERATION protective 
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