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作品数：127被引量：93H指数：5
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相关作者：邓楠姚小泉郭佃顺文晓霞王慧才更多>>
相关机构：中国科学院山东医科大学聊城大学南京航空航天大学更多>>
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Nickel-catalyzed regiodivergent syn-hydrosilylation of disubstituted alkynes
《Science Bulletin》2024年第21期3334-3339,共6页Jixin Wang Jie Lin Zhili Cui Jianlin Yao Konstantin Karaghiosoff Jie Li 
supported by the National Natural Science Foundation of China(22322108);Natural Science Foundation of Jiangsu Province(BK20231521 and BK20221355);Jiangsu Specially Appointed Professors Plan(SR10900122),and start-up funds from Soochow University.
Given the importance of alkenylsilanes in organosilicon chemistry and material science, direct transition-metal-catalyzed selective hydrosilylation of alkynes with hydrosilanes has emerged as apowerful platform for ac...
关键词：CATALYZED ALKYNES SUBSTITUTED 
A General Protocol toward Oxindoles Bearing C_(3)-Allylic Quaternary Stereocenter via Domino Reaction:A Concise Synthesis of Heterocycle-Fused Indoline Alkaloids
《Chinese Journal of Chemistry》2024年第20期2459-2465,共7页Hanxiao Yang Ruoqian Fan Daheng Wen Mengmeng Fan Weiwei Fang 
National Natural Science Foundation of China(No.22101133);Natural Science Foundation of Jiangsu Province(No.BK20200768)and Nanjing Forestry University are greatly acknowledged.
An efficiently catalytic method toward the synthesis of indolin-2-ones featuring an allylic derived C_(3)-quaternary stereocenter via an intramolecular Heck cyclization/Suzuki coupling of N-substituted-N-(2-bromopheny...
关键词：C3-Allylic quaternary stereocenter 3 3'-Disubstituted oxindoles Domino reaction Indoline alkaloids Molecular diversity Nitrogen heterocycles Organohalides Palladacyclic N-heterocyclic carbene 
Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1
《Chinese Chemical Letters》2024年第5期201-206,共6页Yulong Shi Fenbei Chen Mengyuan Wu Xin Zhang Runze Meng Kun Wang Yan Wang Yuheng Mei Qionglu Duan Yinghong Li Rongmei Gao Yuhuan Li Hongbin Deng Jiandong Jiang Yanxiang Wang Danqing Song 
supported by the National Natural Science Foundation of China(No.81974494);CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-070).
Thirty-one new 10,12-disubstituted aloperine derivatives were subtly constructed through a selective oxidation on the 10-α-C-H induced by sulfonyl and a nucleophilic substitution with the stereoselectivity and scalab...
关键词：ALOPERINE SARS-CoV-2 TMPRSS2 SR-B1 Synthesis 
Photocatalytic generation of 1,4-disubstituted 1,2,3-triazoles under metal, oxidant and azide-free conditions
《Green Synthesis and Catalysis》2024年第1期62-67,共6页Changhong Liu Dilshat Abdukerem Wenli Zhu Kun Xia Zechuan Mao Ablimit Abdukader 
The authors acknowledge the financial support from the National Natural Science Foundation of China(Nos.22061040 and 21562039);the Xinjiang Provincial Natural Science Foundation of China(Nos.2022E01069 and 2020D01C024).
Available online A mild and efficient photocatalytic-induced radical method has been developed for[4+1]cycloaddition reaction of 1,4-disubstituted 1,2,3-triazoles with N-tosylhydrazides and primary amines.The reaction...
关键词：PHOTOCATALYTIC TRIAZOLES Cycloaddition reaction Allyl-type radicals 
Discovery and bioassay of disubstituted β-elemene-NO donor conjugates:synergistic enhancement in the treatment of leukemia被引量：2
《Chinese Journal of Natural Medicines》2023年第12期916-926,共11页ZHU Junlong JIANG Xiaoying LUO Xinyu GAO Yuan ZHAO Rui LI Junjie CAI Hong DANG Xiawen YE Xiangyang BAI Renren XIE Tian 
This project was supported by the Natural Science Foundation of Zhejiang province(No.LY20H300004);the National Natural Science Foundation of China(Nos.82073686,81730108,and 81973635);Scientific Research Foundation for Scholars of HZNU(Nos.2021QDL026 and 2019QDL003);the Ministry of Science and Technology of China(High-end foreign experts program,Nos.G20200217005 and G2021017004).
Natural products are essential sources of antitumor drugs.One such molecule,β-elemene,is a potent antitumor compound extracted from Curcuma wenyujin.In the present investigation,a series of novel 13,14-disubstituted ...
关键词：Antitumor activity Chronic myeloid leukemia Β-ELEMENE Nitric oxide donor Structural modification 
Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-disubstituted alkenes enabling the modular synthesis of 1,1,2,2-tetraarylethanes
《Science China Chemistry》2023年第12期3539-3545,共7页Chengxi Zhang Yang Xi Jingping Qu Yifeng Chen 
supported by the National Natural Science Foundation of China (22171079);the Natural Science Foundation of Shanghai (21ZR1480400);the Shanghai Rising-Star Program (20QA1402300);the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03);the Program of Introducing Talents of Discipline to Universities (B16017);the Fundamental Research Funds for the Central Universities。
The highly diastereoselective dicarbofunctionalization of substituted olefins still remains a daunting challenge in synthetic chemistry.Herein,we report a Pd-catalyzed diastereoselective 1,1-diarylation of 1,1-diaryle...
关键词：1 1 2 2-tetraarylethane PALLADIUM cross-coupling reaction ALKENE multicomponent reactions 
Effect of spatial configuration on adhesion of 1,2-disubstituted cyclohexane derivatives
《Chinese Chemical Letters》2023年第8期196-200,共5页Qiao Zhang Yuhang Yin Jingfu Song Gai Zhao Shengyi Dong 
The authors gratefully acknowledge the Outstanding Youth Scientist Foundation of Hunan Province(No.2021JJ10010);the National Natural Science Foundation of China(Nos.22271087,21704024);the Huxiang Young Talent Program from Hunan Province(No.2018RS3036);the Fundamental Research Funds for the Central Universities from Hunan University.
Spatial configuration has a significant effect on chemical self-assembly.However,the importance of spatial configuration in supramolecular adhesive materials has been frequently ignored.In this study,the effects of th...
关键词：Spatial configuration Supramolecular adhesive material ASSEMBLY COHESION ADHESION 
Regio-and enantioselective conjugate addition ofβ-nitroα,β-unsaturated carbonyls to construct 3-alkenyl disubstituted oxindoles被引量：1
《Chinese Chemical Letters》2023年第1期337-341,共5页Changli He Xiaoxue Tang Xin He Yuqiao Zhou Xiaohua Liu Xiaoming Feng 
financial support from the National Natural Science Foundation of China(No.21890723)。
Reversal of regioselectivity in the catalytic asymmetric conjugate additions of 3-substituted oxindoles toβ-nitroenones orβ-nitroacrylates was established with chiral scandium catalysts.It enabled the construction o...
关键词：Asymmetric catalysis Conjugate addition NITROALKENES Regioselectivity OXINDOLES 
Cross-coupling of 2-methylquinolines and in-situ activated isoquinolines:Construction of 1,2-disubstituted isoquinolinones
《Chinese Chemical Letters》2022年第11期4874-4877,共4页Jianyi Shi Zheng Zeng Shengting Xu Zechun Cai Yuehua Luo Yongbo Fan Zhongzhi Zhu Tingting Wen Xiuwen Chen 
Foundation of the National Natural Science Foundation of China(No.22101212);“Climbing Program”(No.pdjh2021a0505)Special Funds;Science Foundation for Young Teachers of Wuyi University(No.2019td06);Guangdong Basic and Applied Basic Research Foundation(Nos.2019A1515110866,2019A1515110522);College Students Innovation and Entrepreneurship Training Program of Wuyi University(Nos.202111349020,202111349308S)for financial support。
In this study,a method was developed to form C(sp^(3))-C(sp^(2))bonds via copper catalyst-promoted cross coupling of 2-methylquinoline and in-situ-activated 3-haloisoquinoline under mild conditions.The multi-component...
关键词：Isoquinolinones In-situ activated Three-component reaction One-pot Trifunctionalisation 
Highly Stereoselective Synthesis of 2,2-Disubstituted Vinylphosphonates via Aryl to Vinyl 1,4-Palladium Migration被引量：1
《Chinese Journal of Chemistry》2022年第18期2188-2192,共5页Yan-Zhen Chen Geng-Yu Bao Xin-Chen Zhan Jian-Guo Fu Xiao-Ming Ji Shu-Sheng Zhang Chen-Guo Feng 
supported by the National Natural Science Foundation of China(21871284 and 91956113);the fellowship of China Postdoctoral Science Foundation(2021M692152);the Science and Technology Commission of Shanghai Municipality(20XD1423400,21ZR1482100 and 22ZR1458900);the Shanghai Municipal Education Commission(2019-01-07-0010-E00072);the Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology.
Vinylphosphates play an important role in the fields of synthetic chemistry,pharmaceuticals and material science.It is a long-standing challenge to control the geometry of multi-substituted vinylphosphates.Herein,an e...
关键词：1 4-Palladium migration Phosphorylation C-H activation STEREOSELECTIVITY CROSS-COUPLING 
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