EDEMA

作品数：295被引量：679H指数：15
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Reviving the use of inhibitors of matrix metalloproteases in spinal cord injury:a case for specificity
《Neural Regeneration Research》2023年第9期1925-1930,共6页Zubair Ahmed 
At present,there are no resto rative therapies in the clinic for spinal cord injury,with current treatments offering only palliative treatment options.The role of matrix metalloproteases is well established in spinal ...
关键词：axon regeneration blood-spinal cord barrier EDEMA functional recovery matrix metalloprotease-9 matrix metalloproteses-12 PAIN spinal cord injury 
Elevated intraspinal pressure in traumatic spinal cord injury is a promising therapeutic target被引量：4
《Neural Regeneration Research》2022年第8期1703-1710,共8页Chao-Hua Yang Zheng-Xue Quan Gao-Ju Wang Tao He Zhi-Yu Chen Qiao-Chu Li Jin Yang Qing Wang 
supported by a grant from Chongqing Yingcai Plan Project,No.cstc2021ycjh-bgzxm0041(to ZXQ).
The currently recommended management for acute traumatic spinal cord injury aims to reduce the incidence of secondary injury and promote functional recovery.Elevated intraspinal pressure(ISP)likely plays an important ...
关键词：blood-spinal cord barrier DECOMPRESSION DURAPLASTY durotomy EDEMA hemorrhage intraspinal pressure MYELOTOMY spinal cord injury therapeutic target 
Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis被引量：20
《Neural Regeneration Research》2022年第1期194-202,共9页Yan Zhou Lu-Lu Wen Yan-Fei Li Kai-Min Wu Ran-Ran Duan Yao-Bing Yao Li-Jun Jing Zhe Gong Jun-Fang Teng Yan-Jie Jia 
supported by the National Natural Science Foundation of ChinaNo.U1604170(to YJJ)。
Mesenchymal stem cell(MSC)transplantation is a promising treatment strategy for spinal cord injury,but immunological rejection and possible tumor formation limit its application.The therapeutic effects of MSCs mainly ...
关键词：blood-spinal cord barrier EDEMA EXOSOME PERICYTE NOD1 pro-caspase 1 PYROPTOSIS spinal cord injury 
Acute effects of human protein S administration after traumatic brain injury in mice被引量：1
《Neural Regeneration Research》2020年第11期2073-2081,共9页Xiaowei Wang Jing Tong Xiaodi Han Xiaoming Qi Jun Zhang Erxi Wu Jason H.Huang 
supported in part by a University of Rochester Institutional Grant(2011NSG-Huang,to JHH);National Institute of Health(NIH-R01-NS-067435,to JHH);the Hellen Vosberg McCrillus Plummer and Robert Edward Lee Plummer,Jr,Endowment fund from Baylor Scott&White Medical Center(to JHH)。
Despite years of effort,no effective acute phase treatment has been discovered for traumatic brain injury.One impediment to successful drug development is entangled secondary injury pathways.Here we show that protein ...
关键词：apoptosis AQUAPORIN-4 controlled CORTICAL impact EDEMA inflammation protein S TBI therapy TRAUMATIC brain injury 
MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis被引量：1
《Neural Regeneration Research》2019年第11期1919-1931,共13页Nan-Xing Yi Long-Yun Zhou Xiao-Yun Wang Yong-Jia Song Hai-Hui Han Tian-Song Zhang Yong-Jun Wang Qi Shi Hao Xu Qian-Qian Liang Ting Zhang 
supported by the National Natural Science Foundation of China,No.81822050(to QQL),81873321(to HX),81673990(to QQL),81330085(to QS),81730107(to YJW);the Shanghai Municipal Health and Family Planning Commission TCM Research Project of China,No.2018JP014(to HX);the Three-Year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals of China,No.16CR1017A(to YJW);the Shanghai Traditional Chinese Medicine Chronic Disease [Malignant Tumor,Bone Degenerative Disease] Clinical Medical Center of China,No.2017ZZ01010(to YJW);the National Ministry of Education Innovation Team of China,No.IRT1270(to YJW);the Innovation Team of Key Fields of the Ministry of Science and Technology of China,No.2015RA4002(to YJW);the Outstanding Principle Investigator Project of Guanghua Hospital,Changning District,Shanghai,China,No.2016-01(to QS),2016-06(to YJW)
OBJECTIVE: To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury.DATA SOURCES: Key terms were "stroke","brain diseases","brain injuries","brain hemorrhage, t...
关键词：nerve REGENERATION acute BRAIN injury neurological function spatial cognition water MAZE test LESION volume BRAIN EDEMA rat systematic review META-ANALYSIS neural REGENERATION 
Magnesium:pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage被引量：7
《Neural Regeneration Research》2019年第7期1116-1121,共6页Jason J.Chang Rocco Armonda Nitin Goyal Adam S.Arthur 
Intracerebral hemorrhage(ICH) remains the second-most common form of stroke with high morbidity and mortality.ICH can be divided into two pathophysiological stages:an acute primary phase,including hematoma volume expa...
关键词：INTRACEREBRAL HEMORRHAGE stroke magnesium VASODILATION HEMOSTASIS blood-brain barrier perihematomal EDEMA 
Dynamic changes in intramedullary pressure 72 hours after spinal cord injury被引量：1
《Neural Regeneration Research》2019年第5期886-895,共10页Xin Zhang Chang-Bin Liu De-Gang Yang Chuan Qin Xue-Chao Dong Da-Peng Li Chao Zhang Yun Guo Liang-Jie Du Feng Gao Ming-Liang Yang Jian-Jun Li 
supported by the National Natural Science Foundation of China,No.81272164(to JJL);the Special Fund for Basic Scientific Research of Central Public Research Institutes in China,No.2016CZ-4(to JJL),2018CZ-1(to JJL);the Beijing Institute for Brain Disorders in China,No.0000-100031(to JJL);the Basic Scientific Research Foundation of China Rehabilitation Research Center,No.2017ZX-22,2017ZX-20(to JJL)
Intramedullary pressure increases after spinal cord injury, and this can be an important factor for secondary spinal cord injury. Until now there have been no studies of the dynamic changes of intramedullary pressure ...
关键词：nerve REGENERATION secondary SPINAL cord injury telemetry PATHOLOGICAL mechanism rabbit CONSCIOUS anesthetized HEMORRHAGE EDEMA pressure measurement blood-spinal barrier neural REGENERATION 
Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury被引量：5
《Neural Regeneration Research》2016年第7期1128-1133,共6页Hai-jun Bao Hai-yang Qiu Jin-xia Kuai Cheng-jie Song Shao-xian Wang Chao-qun Wang Hua-bin Peng Wen-can Han Yong-ping Wu 
supported by the National Natural Science Foundation of China,No.81302612;the Natural Science Foundation of Jiangsu Province of China,No.12KJB310018;a grant from the Student Innovation Training Program of China,No.201410313023Z
The adipocytokine,apelin-13,is an abundantly expressed peptide in the nervous system.Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy.Howe...
关键词：traumatic hippocampus cortex suppressing caspase minutes autophagy destruction hemisphere edema 
Neuroprotective effects of bloodletting at Jing points combined with mild induced hypothermia in acute severe traumatic brain injury被引量：18
《Neural Regeneration Research》2016年第6期931-936,共6页Yue Tu Xiao-mei Miao Tai-long Yi Xu-yi Chen Hong-tao Sun Shi-xiang Cheng Sai Zhang 
supported by the National Natural Science Foundation of China,No.31200809
Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of bloodletting a...
关键词：traumatic alone edema neurological minutes hematoma hematoxylin olfactory neuronal twice 
Recent advances and future directions in preclinical research of argininevasopressin(AVP) receptor blocker conivaptan in the context of stroke被引量：5
《Neural Regeneration Research》2016年第3期392-393,共2页Emil Zeynalov Susan M.Jones 
Funding provided by the Swedish Medical Center to J.Paul Elliott,MD.Author Contributions:EZ-writing of the manuscript,SMJ-writing of the manuscript
Stroke is a major cause of mortality and permanent disability.The onset of stroke is followed by life-threatening pathophysiological responses including brain edema,elevation of intracranial pressure,disruption of blo...
关键词：edema permanent disability intracranial elevation blocker infarct disruption advances mortality 
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