supported by Grants from the National Natural Science Foundation of China(Nos.81372409,81402532);the Sun Yat-sen University Clinical Research 5010 Program(No.2012011)
Background: According to the 7 th edition of the American Joint Committee on Cancer(AJCC) staging system, over50% of patients with nasopharyngeal carcinoma(NPC) have N1 disease at initial diagnosis. However, patients ...
supported by the National Basic Research Program of China[2011CB504300(Y.T.;Y.C.),2015CB553903(Y.T.)];the National High Technology Research and Development Program of China(863 Program)[2012AA02A501(Y.C.)];the National Natural Science Foundation of China[81,171,881 and81372427(Y.T.),81271763(S.L.),81,302,354(Y.S.)];the Hunan Natural Science Foundation of China[12JJ1013(Y.T.)]
Viral infections contribute to approximately 12%of cancers worldwide,with the vast majority occurring in developing countries and areas.Two DNA viruses,Epstein-Barr virus(EBV) and human papillomavirus(HPV),are associa...
Background Epstein-Barr virus (EBV) commonly infects the general population and has been associated withnasopharyngeal carcinoma (NPC), which has a high incidence in certain regions.This study aimed to address how...
Although Epstein-Barr virus(EBV)is present in the malignant Hodgkin/Reed-Sternberg(HRS)cells of a proportion of cases of classical Hodgkin lymphoma(c HL),how the virus contributes to the pathogenesis of this disease r...
supported by a grant from the Cancer Research UK,London(Programme Award C5575/A15032)
In 1964,a new herpesvirus,Epstein-Barr virus(EBV),was discovered in cultured tumor cells derived from a Burkitt lymphoma(BL)biopsy taken from an African patient.This was a momentous event that reinvigorated research i...
supported by Cancer Research UK and the European Commission’s FP6 Life-Sciences-Health Programme(INCA Project:LSHC-CT-2005-018704)
Since its discovery 50 years ago,Epstein-Barr virus(EBV)has been linked to the development of cancers originating from both lymphoid and epithelial cells.Approximately 95%of the world’s population sustains an asympto...
The special November and December issues of the Chinese Journal of Cancer celebrate the 50th anniversary of the discovery of Epstein-Barr virus(EBV) with a series of reviews covering the association of the virus with ...
supported by funding from the Focus Investigation Scheme-A of The Chinese University of Hong Kong;the Research Grants Council of Hong Kong, GRF (471211, 470312), CRF (CUHK8/CRF/11R) and AoE NPC (AoE/M-06/08);the Theme-Based Research Scheme (T12-401/13-R)
Although the Epstein-Barr virus(EBV) has spread to all populations in the world, EBV-associated nasopharyngeal carcinoma(NPC) is prevalent only in South China and Southeast Asia. The role of EBV in the malignant trans...
supported by the Research Grants Council Area of Excellence grant (AoE/M-06/08)
The interplay between host cell genetics and Epstein-Barr virus(EBV) infection contributes to the development of nasopharyngeal carcinoma(NPC). Understanding the host genetic and epigenetic alterations and the influen...
National Natural Science Foundation of China (No30740068);Natural Science Foundation of Shandong Province, China(No Y2008C90)
Background and Objective: EBV BamHI fragment H rightward open reading frame 1 (BHRF1), the Epstein-Barr virus (EBV) early gene, is structurally and functionally homologous to the oncogene bcl-2 and may play an importa...