EQUOL

作品数:18被引量:38H指数:4
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相关领域:医药卫生更多>>
相关作者:卢宗亮易龙刘凯郝庆红糜漫天更多>>
相关机构:第三军医大学南京医科大学河北农业大学第三军医大学大坪医院更多>>
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Identification of metabolites from the gut microbiota in hypertension via network pharmacology and molecular docking
《Bioresources and Bioprocessing》2024年第1期1324-1339,共16页Wenjie Zhang Yinming Zhang Jun Li Jiawei Tang Ji Wu Zicong Xie Xuanchun Huang Shiyi Tao Tiantian Xue 
supported by the National Key Research and Development Program of China(No.2022YFC3500102).
Hypertension is the most prevalent cardiovascular disease,affecting one-third of adults.All antihypertensive drugs have potential side effects.Gut metabolites influence hypertension.The objective of this study was to ...
关键词:HYPERTENSION Gut microbiota METABOLITE Network pharmacology Molecular docking EQUOL 
雌马酚(S-equol, Eq)对慢性不可预知温和刺激小鼠抑郁样行为的改善作用被引量:1
《大豆科学》2022年第6期726-732,共7页张瑛毓 韦震 任梓溢 刘佳萌 孙晶 范蓓 刘新民 卢聪 王凤忠 
国家大豆产业技术体系(CARS-04);中国农业科学院农产品加工研究所创新工程(CAAS-ASTIP-2022-IFST);中国农业科学院基本科研业务费专项院级统筹项目(Y2022LM09)。
为探究雌马酚(S-equol, Eq)对慢性不可预知温和刺激抑郁模型(Chronic Unpredictable Mild Stress, CUMS)小鼠的改善作用,试验设空白组(Con)、模型组(CUMS)、雌马酚低剂量组(Eq-L,10 mg·kg-1)、雌马酚中剂量组(Eq-M,20 mg·kg-1)和雌马...
关键词:雌马酚 慢性不可预知温和刺激抑郁模型 下丘脑-垂体-肾上腺轴 
S-Equol调节SREBP通路和PPARγ改善大鼠2型糖尿病合并非酒精性脂肪肝的研究被引量:1
《陆军军医大学学报》2022年第22期2266-2274,共9页徐喆 倪向敏 李硕 张贵明 崔涵强 王建 
国家自然基金面上项目(81973040);国家自然基金青年科学基金项目(81602855)
目的分析S-雌马酚(S-Equol)对2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)大鼠模型糖脂代谢的影响。方法选取6周龄雄性SD大鼠50只,适应性饲养1周,随机分为对照组(n=10)和建...
关键词:S-雌马酚 大鼠 2型糖尿病 非酒精性脂肪肝 
The Contradictory Effects of Equol on Breast Cancer被引量:2
《Journal of Nutritional Oncology》2017年第4期171-183,共13页Zong Liang Lu Xin Lin Ming Xing Zhu Hong Xia Xu 
an NSFC grants from the National Natural Science Foundation of China(No.81171991)to Hong Xia Xu;National Natural Science Foundation of China(No.81603347)to Zong Liang Lu.
Natural products and their derivatives provide an attractive source for novel preventive and therapeutic agents.Epidemiological studies have indicated that the low incidence of breast cancer in Asian women may be rela...
关键词:SOY ISOFLAVONE S-equol R-equol BREAST Cancer DAIDZEIN 
Correlation of Equol (7-Hydroxy-3-(4-Hydroxyphenyl)Chroman) in Woman Urine with the Symptoms of Menopause
《Journal of Biosciences and Medicines》2016年第1期132-138,共7页Rima Yulia Effriyanti Tita Husnitawati Madjid Hanom Husni Syam 
Objective: In order to identify the correlation between equol excreted through human urine and the symptom of menopause. Methods: The method used is cross sectional study examined to 99 postmenopausal women fulfilling...
关键词:EQUOL Menopause Symptoms Menopause Rating Scale 
Cancer therapy using natural ligands that target estrogen receptor beta被引量:5
《Chinese Journal of Natural Medicines》2015年第11期801-807,共7页Gangadhara R Sareddy Ratna K.Vadlamudi 
supported by the NIH/NCI grant CA178499-01(RKV);CPRIT Training grant RP140105(GRS);2014-15 ABTA Discovery grant(GRS)
Estrogen receptor beta(ERβ) is one of the two key receptors(ERα, ERβ) that facilitate biological actions of 17β-estradiol(E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during...
关键词:Estrogen receptor Estrogen receptor beta Tumor suppressor ER beta agonists LIQUIRITIGENIN S-equol GENISTEIN 
Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway被引量:10
《World Journal of Gastroenterology》2015年第36期10385-10399,共15页Zhi-Ping Yang Yan Zhao Fang Huang Jie Chen Ya-Hong Yao Jun Li Xiao-Nan Wu 
Supported by Special Project on the Integration of Industry,Education and Research of Fujian Province,China,No.2012N0014
AIM: To investigate the anti-tumor effects of equol in gastric cancer cells and the underlying molecular mechanisms.METHODS: MGC-803 cells were employed for in vitro experiments in this study. Cells were treated with ...
关键词:EQUOL APOPTOSIS CHEMOPREVENTION GASTRIC cancer G0/ 
Bioconversion of genistein to(–)-5-hydroxy-equol by a newly isolated cock intestinal anaerobic bacterium被引量:1
《Journal of Chinese Pharmaceutical Sciences》2015年第7期442-448,共7页谢雁景 刘子光 高雅宁 王秀伶 郝庆红 于秀梅 
National Natural Science Foundation of China(Grant No.31170058);the Service Center for Experts and Scholars of Hebei Province(Grant No.CPRC027)
A newly isolated bacterium, named as AUH-JLC257, was found to be capable of bioconverting isoflavone genistein to 5-hydroxy-equol under anaerobic conditions. The metabolite 5-hydroxy-equol was identified by using UV s...
关键词:GENISTEIN 5-Hydroxy-equol Bacterial isolation Identification Microbial biotransformation 
<i>In Vitro</i>Effect of Soy Isoflavone and Equol on Soluble CD40L Release Stimulated by Ristocetin in Platelets from Postmenopause Women被引量:2
《Journal of Biomedical Science and Engineering》2015年第1期24-30,共7页Natalia Gonzalez Argelia Garrido Ingrid Acevedo Luis Valladares 
The inhibition of specific flavonoid on the in vitro platelet aggregation induced by collagen, arachidonic acid and thromboxane A2 (TxA2) agonist, seems to be related mostly to their ability to compete for binding to ...
关键词:Platelet sCD40L Phyoestrogen ISOFLAVONE EQUOL 
Effects of (–)-5-hydroxy-equol on the lifespan and stress resistance of Caenorhabditis elegans
《Journal of Chinese Pharmaceutical Sciences》2014年第6期378-384,共7页张聪慧 王秀伶 梁晓琳 张红蕾 郝庆红 
National Natural Science Foundation of China(Grant No.31170058);the Service Center for Experts and Scholars of Hebei Province(Grant No.CPRC027)
Caenorhabditis elegans (C. elegans) was used as an animal model to study the effect of (-)-5-hydroxy-equol, a microbialmetabolite of isoflavone genistein, on the lifespan, fecundity and resistance against thermal ...
关键词:(-)-5-Hydroxy-equol Caenorhabditis elegans LIFESPAN Thermal stress Oxidative stress FECUNDITY Insulin/IGF-1signaling pathway 
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