supported by the National Key Research and Development Program of China(No.2022YFC3500102).
Hypertension is the most prevalent cardiovascular disease,affecting one-third of adults.All antihypertensive drugs have potential side effects.Gut metabolites influence hypertension.The objective of this study was to ...
an NSFC grants from the National Natural Science Foundation of China(No.81171991)to Hong Xia Xu;National Natural Science Foundation of China(No.81603347)to Zong Liang Lu.
Natural products and their derivatives provide an attractive source for novel preventive and therapeutic agents.Epidemiological studies have indicated that the low incidence of breast cancer in Asian women may be rela...
Objective: In order to identify the correlation between equol excreted through human urine and the symptom of menopause. Methods: The method used is cross sectional study examined to 99 postmenopausal women fulfilling...
supported by the NIH/NCI grant CA178499-01(RKV);CPRIT Training grant RP140105(GRS);2014-15 ABTA Discovery grant(GRS)
Estrogen receptor beta(ERβ) is one of the two key receptors(ERα, ERβ) that facilitate biological actions of 17β-estradiol(E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during...
Supported by Special Project on the Integration of Industry,Education and Research of Fujian Province,China,No.2012N0014
AIM: To investigate the anti-tumor effects of equol in gastric cancer cells and the underlying molecular mechanisms.METHODS: MGC-803 cells were employed for in vitro experiments in this study. Cells were treated with ...
National Natural Science Foundation of China(Grant No.31170058);the Service Center for Experts and Scholars of Hebei Province(Grant No.CPRC027)
A newly isolated bacterium, named as AUH-JLC257, was found to be capable of bioconverting isoflavone genistein to 5-hydroxy-equol under anaerobic conditions. The metabolite 5-hydroxy-equol was identified by using UV s...
The inhibition of specific flavonoid on the in vitro platelet aggregation induced by collagen, arachidonic acid and thromboxane A2 (TxA2) agonist, seems to be related mostly to their ability to compete for binding to ...
National Natural Science Foundation of China(Grant No.31170058);the Service Center for Experts and Scholars of Hebei Province(Grant No.CPRC027)
Caenorhabditis elegans (C. elegans) was used as an animal model to study the effect of (-)-5-hydroxy-equol, a microbialmetabolite of isoflavone genistein, on the lifespan, fecundity and resistance against thermal ...