supported by the Institute of Civil Military Technology Cooperation funded by the Defense Acquisition Program Administration and Ministry of Trade,Industry and Energy of Korean government under grant No 23-CM-AI-08.
Amidst the ever-growing interest in high-mass-loading Li battery electrodes,a persistent challenge has been the insufficient continuity of their ion/electron conduction pathways.Here,we propose cellulose elementary fi...
supported by the National Natural Science Foundation of China,Nos.82271447,81771382;the National Key Research and Development Program of China,No.2019 YFE0115900;the"New 20 Terms of Universities in Jinan,No.202228022 (all to ZZ)。
α-Synuclein is a protein that mainly exists in the presynaptic terminals.Abnormal folding and accumulation of α-synuclein are found in several neurodegenerative diseases,including Parkinson’s disease.Aggregated and...
BACKGROUND Glomerulopathy with fibrillary deposits is not uncommon in routine nephropathology practice,with amyloidosis and fibrillary glomerulonephritis being the two most frequently encountered entities.Renal amyloi...
supported by the National Natural Science Foundation of China(22178048,22007008);the LiaoNing Revitalization Talents Program(XLYC1902001,XLYC1907021);the Fundamental Research Funds for the Central Universities(DUT18RC(3)062,DUT19RC(3)009,DUT23YG120).
Metastable endoperoxides with beta-amyloid fibrils targeting benzothiazole moieties were designed and synthesized.Singlet oxygen released from these endoperoxides by thermal cycloreversion reaction was shown to cause ...
University of Florence(Fondi Ateneo to RC and CC);Ministry of Education,Universities and Research of Italy(Progetto Dipartimento di Eccellenza to CC)。
The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and...
supported by the National Institute of General Medical Sciences(R35GM136223);a grant from Daylight Solutions,and a grant(2023-321163);the Chan Zuckerberg Initiative Donor-Advised Fund at the Silicon Valley Community Foundation.
Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases.However,it remains a grand challenge to extract molecular structure information from intracellular amyloid proteins in their native c...
supported by the National Key Research and Development Programs of China(No.2018YFA0209700);the Fund of the Frontiers Science Center for New Organic Matter,Nankai University,China(No.63181206);the National Natural Science Foundation of China(Nos.22077073,22007051);the Fundamental Research Funds for the Central Universities,Nankai University,China(No.63206015);the China Postdoctoral Science Foundation (No.2019M660975).
Accumulation of β-amyloid(Aβ) fibrils in the brain is one of the main culprits in Alzheimer’s disease(AD) progression, which initiates the neuronal damage and subsequent neurodegeneration. Various anti-Aβ agents h...
This project received funding from the European Union Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie grant agreement no.872233(“PEPSA-MATE”).GB acknowledges CINECA and the EU-PRACE program for the CPU time.FC acknowledges the funding received as an award of an RMIT senior vice chancellor fel-lowship.
The biological properties of therapeutic peptides,such as their pharmacokinetics and pharmacodynamics,are correlated with their structure and aggregation properties.Herein,we studied the aggregation properties of a th...
supported by the National Natural Science Foundation of China(51773099,51933006)。
The deposition of highly ordered amyloid fibrils is recognized as a hallmark of amyloidosis diseases such as Alzheimer’s disease and Parkinson’s disease.Disaggregating the amyloid fibrils is considered as one of the...
supported by grants from the Academy of Finland#293392,#319195;Päivikki and Sakari Sohlberg Foundation(to AD);Polish National Science Centre grant 2019/35/D/NZ7/03200-Sonata 15(to PC).
Parkinson’s disease(PD)is the second most common neurodegenerative disorder characterized by multiple motor and nonmotor symptoms,which include,among others,constipation,sleep disturbance,bradykinesia,gait and balanc...