SYNUCLEINOPATHIES

作品数：12被引量：13H指数：2
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相关期刊：《Acta Pharmacologica Sinica》《Neuroimmunology and Neuroinflammation》《Neural Regeneration Research》《Translational Neurodegeneration》更多>>
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α-Synuclein pathology from the body to the brain:so many seeds so close to the central soil被引量：1
《Neural Regeneration Research》2024年第7期1463-1472,共10页Yunying Yang Zhentao Zhang 
supported by the National Natural Science Foundation of China,Nos.82271447,81771382;the National Key Research and Development Program of China,No.2019 YFE0115900;the"New 20 Terms of Universities in Jinan,No.202228022 (all to ZZ)。
α-Synuclein is a protein that mainly exists in the presynaptic terminals.Abnormal folding and accumulation of α-synuclein are found in several neurodegenerative diseases,including Parkinson’s disease.Aggregated and...
关键词：aggregation autonomic nervous system barrier receptors body fluid circulation in situ generation Parkinson’s disease PHOSPHORYLATION propagation SYNUCLEINOPATHIES Α-SYNUCLEIN α-synuclein fibrils 
Blood-brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy被引量：2
《Translational Neurodegeneration》2024年第1期551-574,共24页Kristina Lau Rebecca Kotzur Franziska Richter 
funded by intramural funds with no role in writing of the manuscript.
There is increasing evidence for blood-brain barrier(BBB)alterations in Parkinson’s disease(PD),the second most common neurodegenerative disorder with rapidly rising prevalence.Altered tight junction and transporter ...
关键词：Neurovascular unit SYNUCLEINOPATHIES Α-SYNUCLEIN 
α-Synuclein seeding amplification assays for diagnosing synucleinopathies:an innovative tool in clinical implementation
《Translational Neurodegeneration》2024年第1期219-235,共17页Yaoyun Kuang Hengxu Mao Xiaoyun Huang Minshan Chen Wei Dai Tingting Gan Jiaqi Wang Hui Sun Hao Lin Qin Liu Xinling Yang Ping-Yi Xu 
supported by the National Natural Science Foundation of China(81870856,81870992,82071416);the Central Government Guiding Local Science and Technology Development Projects(ZYYD2022C17);the Key Research and Development Program of Guangzhou(2023B03J0631);the Municipal University(Faculty)Joint Funding Project(202102010010);the Guangdong Basic and Applied Basic Research Foundation(2022B1515230004);the Guangzhou Science and Technology Bureau 2024 Basic Research Program Municipal University(Institute)Joint Funding“Dengfeng Hospital”(2023A03J01331);the Guangzhou Science and Technology Bureau Municipal University(Institute)Joint Funding Project Basic and Applied Basic Research Project(202201020397);the Second Affiliated Hospital of Xinjiang Medical University,the State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia(SKL-HIDCA-2022-NKX1).
The spectrum of synucleinopathies,including Parkinson’s disease(PD),multiple system atrophy(MSA),and dementia with Lewy bodies(DLB),is characterized byα-synuclein(αSyn)pathology,which serves as the definitive diagn...
关键词：Α-SYNUCLEIN Movement disorders Seed amplification assay Quiescent seed amplification assay Diagnosis 
Overlaps and divergences between tauopathies and synucleinopathies:a duet of neurodegeneration
《Translational Neurodegeneration》2024年第1期861-873,共13页Wen Li Jia-Yi Li 
supported by the National Natural Science Foundation of China(82371273,81430025,U1801681 to J-Y.L.and W.L.);the Key Field Research Development Program of Guangdong Province(2018B030337001);the Swedish Research Council(2019-01551,2023-02216);ParkinsonFonden(1351/21,1421/22,1494/23);the Strategic Research Area Multipark(Multidisciplinary research in Parkinson’s disease at Lund University);Hjarnfonden(FO2022-0282,FO2023-0397,PS2018-0062);Svenska Sällskapet för Medicinsk Forskning(SSMF,P18-0194).
Proteinopathy,defined as the abnormal accumulation of proteins that eventually leads to cell death,is one of the most significant pathological features of neurodegenerative diseases.Tauopathies,represented by Alzheime...
关键词：TAUOPATHY SYNUCLEINOPATHY Tau α-Synuclein NEURODEGENERATION 
α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies被引量：1
《Neural Regeneration Research》2023年第11期2332-2342,共11页Alessandra Bigi Roberta Cascella Cristina Cecchi 
University of Florence(Fondi Ateneo to RC and CC);Ministry of Education,Universities and Research of Italy(Progetto Dipartimento di Eccellenza to CC)。
The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and...
关键词：amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding 
Fatty acid-binding protein 7 triggersα-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress被引量：3
《Acta Pharmacologica Sinica》2022年第3期552-562,共11页An Cheng Yi-fei Wang Yasuharu Shinoda Ichiro Kawahata Tetsunori Yamamoto Wen-bin Jia Hanae Yamamoto Tomohiro Mizobata Yasushi Kawata Kohji Fukunaga 
This work was supported in part by the Strategic Research Program for Brain Sciences from Japan Agency for Medical Research and Development(JP17dm0107071,JP18dm0107071,JP19dm0107071,and JP20dm0107071;awarded to KF).
We previously show that fatty acid-binding protein 3(FABP3)triggersα-synuclein(Syn)accumulation and induces dopamine neuronal cell death in Parkinson disease mouse model.But the role of fatty acid-binding protein 7(F...
关键词：SYNUCLEINOPATHIES α-synuclein oligomerization fatty acid binding protein 7 arachidonic acid psychosine cell death 
Targeting transglutaminase 2 as a potential disease modifying therapeutic strategy for synucleinopathies
《Neural Regeneration Research》2021年第8期1560-1561,共2页Jie Zhang Hilary Grosso Jasutkar M.Maral Mouradian 
supported by grants from the Michael J. Fox Foundation for Parkinson’s Research (ID 12350);the American Parkinson Disease Association, the New Jersey Health Foundation, and by NIH grants NS101134, NS096032, and NS116921。
Synucleinopathies are a group of progressive neurodegenerative disorders characterized by the accumulation of α-synuclein(α-Syn) aggregates in Lewy bodies(LBs) and Lewy neurites(LNs) in Parkinson's disease(PD) and d...
关键词：ATROPHY THERAPEUTIC AGGREGATION 
Organotypic hippocampal slices,an emerging tool to model synucleinopathies
《Neural Regeneration Research》2021年第5期999-1000,共2页Sara Elfarrash Poul Henning Jensen 
Parkinson’s disease(PD)is the second most common neurodegenerative disease after Alzheimer’s disease.PD has been traditionally considered a motoric disorder characterized by tremor,rigidity and bradykinesia,however ...
关键词：ALZHEIMER IMPAIRMENT settled 
Dysfunctional glia:contributors to neurodegenerative disorders被引量：1
《Neural Regeneration Research》2021年第2期218-222,共5页Marta Sidoryk-Węgrzynowicz Lidia Strużyńska 
statutory funds provided by the Polish Ministry of Science and Higher Education for Mossakowski Medical Research Centre Polish Academy of Sciences,Warsaw,Poland(9/2018,to LS)。
Astrocytes are integral components of the central nervous system,where they are involved in numerous functions critical for neuronal development and functioning,including maintenance of blood-brain barrier,formation o...
关键词：ASTROCYTES microglia NEURODEGENERATION neuroinflammation synaptic dysfunction SYNUCLEINOPATHIES TAUOPATHIES 
Assessment of cerebrospinal fluid α-synuclein as a potential biomarker in Parkinson's disease and synucleinopathies
《Neuroimmunology and Neuroinflammation》2020年第2期132-140,共9页Ioanna Chalatsa Katerina Melachroinou Evangelia Emmanouilidou Kostas Vekrellis 
The discovery of diagnostic and prognostic biomarkers for neurodegenerative diseases represents an unmet clinical challenge. For example, the diagnosis of Parkinson's disease (PD) relies mainly on the presence of clin...
关键词：Cerebrospinal fluid Α-SYNUCLEIN Parkinson's disease BIOMARKER EXOSOMES SYNUCLEINOPATHIES 
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