GENE_ONTOLOGY

作品数：73被引量：174H指数：7
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相关作者：郭政朱晶曹顺良李亦学朱扬勇更多>>
相关机构：哈尔滨医科大学浙江大学上海生物信息技术研究中心复旦大学更多>>
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RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration被引量：4
《Neural Regeneration Research》2024年第8期1812-1821,共10页Xinyang Zhou Yehua Lv Huimin Xie Yan Li Chang Liu Mengru Zheng Ronghua Wu Songlin Zhou Xiaosong Gu Jingjing Li Daguo Mi 
supported by the National Natural Science Foundation of China,No.81870975(to SZ)。
Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after injury.Long non-coding RNAs(IncRNAs)have been reported t...
关键词：ceRNA network EXOSOMES fibroblast cells Gene Ontology(GO) Kyoto Encyclopedia of Genes and Genomes(KEGG) protein-protein interaction(PPI)networks RNA-seq Schwann cells 
Transcriptomic and bioinformatics analysis of the mechanism by which erythropoietin promotes recovery from traumatic brain injury in mice被引量：1
《Neural Regeneration Research》2024年第1期171-179,共9页Weilin Tan Jun Ma Jiayuanyuan Fu Biying Wu Ziyu Zhu Xuekang Huang Mengran Du Chenrui Wu Ehab Balawi Qiang Zhou Jie Zhang Zhengbu Liao 
supported by the National Natural Science Foundation of China,No.81771355;the Natural Science Foundation of Chongqing Science and Technology Bureau,Nos.CSTC2015jcyjA10096,cstc2021jcyj-msxmX0262(all to ZL)。
Recent studies have found that erythropoietin promotes the recovery of neurological function after traumatic brain injury.However,the precise mechanism of action remains unclea r.In this study,we induced moderate trau...
关键词：axon guidance bioinformatics analysis competing endogenous RNA ERYTHROPOIETIN Gene Ontology Kyoto Encyclopedia of Genes and Genomes non-coding RNA RNA sequencing transcriptomics traumatic brain injury 
Reduced non-CpG methylation is a potential epigenetic target after spinal cord injury
《Neural Regeneration Research》2023年第11期2489-2496,共8页Zhourui Wu Chen Li Ran Zhu Yiqiu Cao Thomas C.Chen Liming Cheng 
National Key Research and Development Program of China,No.2016YFA0100800(to LC);International(Regional)Cooperation and Communication Program of the National Natural Science Foundation of China,No.81820108013(to LC);State Key Program of the National Natural Science Foundation of China,No.81330030(to LC);National Natural Science Foundation of China,Nos.82071370(to ZW),81301042(to LC);Shanghai Pujiang Program,No.19PJ1409200(to ZW);Shanghai Sailing Program,No.21YF1442400(to CL)。
DNA methylation is a critical epigenetic regulator in the occurrence and development of diseases and is closely related to various functional responses in relation to spinal cord injury.To investigate the role of DNA ...
关键词：CpG methylation cytosine fraction differentially methylated regions DNA methylation DNA methyltransferases dynamic signatures Gene Ontology non-CpG methylation single-cell RNA-Seq spinal cord injury 
Differentially expressed whey proteins of donkey and bovine colostrum revealed with a label-free proteomics approach
《Food Science and Human Wellness》2023年第4期1224-1231,共8页Mohan Li Qilong Li Haikun Yu Xiumin Zhang Dehao Li Wanying Song Yan Zheng Xiqing Yue 
supported by the by National Key R&D Program of China(2018YFC1604302);“Twelfth Five Year”National Science and Technology Plan Project(2013BAD18B03);Chinese Scholarship Council(202008210391);Shenyang Technological Innovation Project(Y17-0-028);LiaoNing Revitalization Talents Project(XLYC1902083).
This study aimed to analyze and compare the differentially expressed whey proteins(DEWPs)of donkey and bovine colostrum using high-performance liquid chromatography with tandem mass spectrometry-based proteomics.A tot...
关键词：Bovine colostrum Donkey colostrum PROTEOMICS Whey protein Gene Ontology Kyoto Encyclopedia of Genes and Genomes 
Charcot-Marie-Tooth-1A and sciatic nerve crush rat models:insights from proteomics
《Neural Regeneration Research》2023年第6期1354-1363,共10页Zeina Msheik Stephanie Durand Emilie Pinault Martial Caillaud Laetitia Vignaud Fabrice Billet Mohamed El Massry Alexis Desmoulière 
supported by a doctoral fellowship from the European Union(European Regional Development Fund).
The sensorimotor and histological aspects of peripheral neuropathies were already studied by our team in two rat models:the sciatic nerve crush and the Charcot-Marie-Tooth-1A disease.In this study,we sought to highlig...
关键词：Charcot-Marie-Tooth-1A endoplasmic reticulum Gene Ontology NEUROGENESIS oxidative stress PROTEOMICS rat repair sciatic nerve crush SWATH-MS 
Bioinformatics analysis of ferroptosis in spinal cord injury被引量：13
《Neural Regeneration Research》2023年第3期626-633,共8页Jin-Ze Li Bao-You Fan Tao Sun Xiao-Xiong Wang Jun-Jin Li Jian-Ping Zhang Guang-Jin Gu Wen-Yuan Shen De-Rong Liu Zhi-Jian Wei Shi-Qing Feng 
supported by National Key Research and Development Project of Stem Cell and Transformation Research,No.2019YFA0112100;Tianjin Key Research and Development Plan,Key Projects for Science and Technology Support,No.19YFZCSY00660(both to SQF)。
Ferroptosis plays a key role in aggravating the progression of spinal cord injury(SCI),but the specific mechanism remains unknown.In this study,we constructed a rat model of T10 SCI using a modified Allen method.We id...
关键词：bioinformatics drug ferroptosis Gene Ontology enrichment analysis gene-miRNA network Kyoto Encyclopedia of Genes and Genomes pathway mRNA-miRNA-lncRNA network progression spinal cord injury 
A comparative analysis of differentially expressed genes in rostral and caudal regions after spinal cord injury in rats
《Neural Regeneration Research》2022年第10期2267-2271,共5页Xue-Min Cao Sheng-Long Li Yu-Qi Cao Ye-Hua Lv Ya-Xian Wang Bin Yu Chun Yao 
supported by Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX-2065(to XMC).
The initial mechanical damage of a spinal cord injury(SCI)triggers a progressive secondary injury cascade,which is a complicated process integrating multiple systems and cells.It is crucial to explore the molecular an...
关键词：biological process CAUDAL differentially expressed genes Gene Ontology HEMISECTION IMMUNOSTAINING Rattus norvegicus RNA-sequencing rostral spinal cord injury 
Expression and regulatory network of long noncoding RNA in rats after spinal cord hemisection injury被引量：2
《Neural Regeneration Research》2022年第10期2300-2304,共5页Wei Liu Jin-Cheng Tao Sheng-Ze Zhu Chao-Lun Dai Ya-Xian Wang Bin Yu Chun Yao Yu-Yu Sun 
Long noncoding RNAs(lncRNAs)participate in a variety of biological processes and diseases.However,the expression and function of lncRNAs after spinal cord injury has not been extensively analyzed.In this study of righ...
关键词：bioinformatic analysis biological process gene ontology analysis inflammatory response Kyoto encyclopedia of genes and genomes analysis long noncoding RNAs regulatory network RNA sequencing spinal cord injury synaptic transmission 
TripletGO: Integrating Transcript Expression Profiles with Protein Homology Inferences for Gene Function Prediction
《Genomics, Proteomics & Bioinformatics》2022年第5期1013-1027,共15页Yi-Heng Zhu Chengxin Zhang Yan Liu Gilbert S.Omenn Peter L.Freddolino Dong-Jun Yu Yang Zhang 
supported in part by the National Natural Science Foundation of China(Grant Nos.62072243 and 61772273 to Dong-Jun Yu);the Natural Science Foundation of Jiangsu,China(Grant No.BK20201304 to Dong-Jun Yu);the Foundation of National Defense Key Laboratory of Science and Technology,China(Grant No.JZX7Y202001SY000901 to DongJun Yu);the China Scholarship Council(Grant No.201906840041 to Yi-Heng Zhu);the National Institute of Environmental Health Sciences,USA(Grant No.P30ES017885 to Gilbert S.Omenn);the National Cancer Institute,USA(Grant No.U24CA210967 to Gilbert S.Omenn);the National Institute of General Medical Sciences,USA(Grant Nos.GM136422 and S10OD026825 to Yang Zhang);the National Institute of Allergy and Infectious Diseases,USA(Grant No.AI134678 to Peter L.Freddolino and Yang Zhang);the National Science Foundation,USA(Grant Nos.IIS1901191,DBI2030790,and MTM2025426 to Yang Zhang);used the Extreme Science and Engineering Discovery Environment(XSEDE),which is supported by the National Science Foundation,USA(Grant No.ACI1548562)。
Gene Ontology(GO)has been widely used to annotate functions of genes and gene products.Here,we proposed a new method,Triplet GO,to deduce GO terms of protein-coding and noncoding genes,through the integration of four ...
关键词：Gene function annotation Gene Ontology Transcript expression profile Triplet network Protein-level alignment 
Characteristic analysis of skin keratinocytes in patients with type 2 diabetes based on the single-cell levels被引量：2
《Chinese Medical Journal》2022年第20期2461-2466,共6页Bingye Liao Qiuyi Ouyang Hongqin Song Ziqi Wang Jinhua Ou Jinxin Huang Liang Liu 
Background: Keratinocytes play an important role in wound healing;however, less is known about skin keratinocytes in patients with type 2 diabetes mellitus (T2DM). Therefore, this study aimed to search for the transcr...
关键词：Diabetes mellitus type 2 Gene Ontology KERATINOCYTES Prion diseases Sequence analysis RNA Single-cell analysis TRANSCRIPTOME Wound healing 
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