supported by the National Natural Science Foundation of China,No.81870975(to SZ)。
Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after injury.Long non-coding RNAs(IncRNAs)have been reported t...
supported by the National Natural Science Foundation of China,No.81771355;the Natural Science Foundation of Chongqing Science and Technology Bureau,Nos.CSTC2015jcyjA10096,cstc2021jcyj-msxmX0262(all to ZL)。
Recent studies have found that erythropoietin promotes the recovery of neurological function after traumatic brain injury.However,the precise mechanism of action remains unclea r.In this study,we induced moderate trau...
National Key Research and Development Program of China,No.2016YFA0100800(to LC);International(Regional)Cooperation and Communication Program of the National Natural Science Foundation of China,No.81820108013(to LC);State Key Program of the National Natural Science Foundation of China,No.81330030(to LC);National Natural Science Foundation of China,Nos.82071370(to ZW),81301042(to LC);Shanghai Pujiang Program,No.19PJ1409200(to ZW);Shanghai Sailing Program,No.21YF1442400(to CL)。
DNA methylation is a critical epigenetic regulator in the occurrence and development of diseases and is closely related to various functional responses in relation to spinal cord injury.To investigate the role of DNA ...
supported by a doctoral fellowship from the European Union(European Regional Development Fund).
The sensorimotor and histological aspects of peripheral neuropathies were already studied by our team in two rat models:the sciatic nerve crush and the Charcot-Marie-Tooth-1A disease.In this study,we sought to highlig...
supported by National Key Research and Development Project of Stem Cell and Transformation Research,No.2019YFA0112100;Tianjin Key Research and Development Plan,Key Projects for Science and Technology Support,No.19YFZCSY00660(both to SQF)。
Ferroptosis plays a key role in aggravating the progression of spinal cord injury(SCI),but the specific mechanism remains unknown.In this study,we constructed a rat model of T10 SCI using a modified Allen method.We id...
supported by Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX-2065(to XMC).
The initial mechanical damage of a spinal cord injury(SCI)triggers a progressive secondary injury cascade,which is a complicated process integrating multiple systems and cells.It is crucial to explore the molecular an...
Long noncoding RNAs(lncRNAs)participate in a variety of biological processes and diseases.However,the expression and function of lncRNAs after spinal cord injury has not been extensively analyzed.In this study of righ...
supported by Key Research Projects of Ningxia Hui Autonomous Region of China,No.2018BCG01002(to HCX);the Natural Science Foundation of Ningxia Hui Autonomous Region of China,No.NZ17150(to PY)。
Olfactory ensheathing cells(OECs) from the olfactory bulb(OB) and the olfactory mucosa(OM) have the capacity to repair nerve injury. However, the difference in the therapeutic effect between OB-derived OECs and OM-der...
This study was supported by the National Natural Science Foundation of China(General Program),No.81673411;the United Fund Project of National Natural Science Foundation of China,No.U1803281;Young Medical Talents Award Project of Chinese Academy of Medical Sciences,No.2018RC350013;Chinese Academy of Medical Sciences Innovation Project for Medical Science,No.2017-I2M-1-016(all to RL).
In a previous study,we found that long non-coding genes in Alzheimer’s disease(AD)are a result of endogenous gene disorders caused by the recruitment of microRNA(miRNA)and mRNA,and that miR-200a-3p and other represen...
This study was supported by the National Natural Science Foundation of China,No.31771052(to YW);the National Key R&D Program of China,No.2017YFA0104702(to AJS);the Youth Cultivation Project of Military Medical Science,No.16QNP144(to YW).
In our previous study,we investigated the dynamic expression of cytokines in the distal nerve stumps after peripheral nerve injury using microarray analysis,which can characterize the dynamic expression of proteins.In...