GENE_ONTOLOGY

作品数:73被引量:174H指数:7
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相关作者:郭政朱晶曹顺良李亦学朱扬勇更多>>
相关机构:哈尔滨医科大学浙江大学上海生物信息技术研究中心复旦大学更多>>
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相关基金:国家自然科学基金国家高技术研究发展计划国家重点基础研究发展计划上海市自然科学基金更多>>
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  • 期刊=Neural Regeneration Researchx
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RNA sequencing of exosomes secreted by fibroblast and Schwann cells elucidates mechanisms underlying peripheral nerve regeneration被引量:4
《Neural Regeneration Research》2024年第8期1812-1821,共10页Xinyang Zhou Yehua Lv Huimin Xie Yan Li Chang Liu Mengru Zheng Ronghua Wu Songlin Zhou Xiaosong Gu Jingjing Li Daguo Mi 
supported by the National Natural Science Foundation of China,No.81870975(to SZ)。
Exosomes exhibit complex biological functions and mediate a variety of biological processes,such as promoting axonal regeneration and functional recove ry after injury.Long non-coding RNAs(IncRNAs)have been reported t...
关键词:ceRNA network EXOSOMES fibroblast cells Gene Ontology(GO) Kyoto Encyclopedia of Genes and Genomes(KEGG) protein-protein interaction(PPI)networks RNA-seq Schwann cells 
Transcriptomic and bioinformatics analysis of the mechanism by which erythropoietin promotes recovery from traumatic brain injury in mice被引量:1
《Neural Regeneration Research》2024年第1期171-179,共9页Weilin Tan Jun Ma Jiayuanyuan Fu Biying Wu Ziyu Zhu Xuekang Huang Mengran Du Chenrui Wu Ehab Balawi Qiang Zhou Jie Zhang Zhengbu Liao 
supported by the National Natural Science Foundation of China,No.81771355;the Natural Science Foundation of Chongqing Science and Technology Bureau,Nos.CSTC2015jcyjA10096,cstc2021jcyj-msxmX0262(all to ZL)。
Recent studies have found that erythropoietin promotes the recovery of neurological function after traumatic brain injury.However,the precise mechanism of action remains unclea r.In this study,we induced moderate trau...
关键词:axon guidance bioinformatics analysis competing endogenous RNA ERYTHROPOIETIN Gene Ontology Kyoto Encyclopedia of Genes and Genomes non-coding RNA RNA sequencing transcriptomics traumatic brain injury 
Reduced non-CpG methylation is a potential epigenetic target after spinal cord injury
《Neural Regeneration Research》2023年第11期2489-2496,共8页Zhourui Wu Chen Li Ran Zhu Yiqiu Cao Thomas C.Chen Liming Cheng 
National Key Research and Development Program of China,No.2016YFA0100800(to LC);International(Regional)Cooperation and Communication Program of the National Natural Science Foundation of China,No.81820108013(to LC);State Key Program of the National Natural Science Foundation of China,No.81330030(to LC);National Natural Science Foundation of China,Nos.82071370(to ZW),81301042(to LC);Shanghai Pujiang Program,No.19PJ1409200(to ZW);Shanghai Sailing Program,No.21YF1442400(to CL)。
DNA methylation is a critical epigenetic regulator in the occurrence and development of diseases and is closely related to various functional responses in relation to spinal cord injury.To investigate the role of DNA ...
关键词:CpG methylation cytosine fraction differentially methylated regions DNA methylation DNA methyltransferases dynamic signatures Gene Ontology non-CpG methylation single-cell RNA-Seq spinal cord injury 
Charcot-Marie-Tooth-1A and sciatic nerve crush rat models:insights from proteomics
《Neural Regeneration Research》2023年第6期1354-1363,共10页Zeina Msheik Stephanie Durand Emilie Pinault Martial Caillaud Laetitia Vignaud Fabrice Billet Mohamed El Massry Alexis Desmoulière 
supported by a doctoral fellowship from the European Union(European Regional Development Fund).
The sensorimotor and histological aspects of peripheral neuropathies were already studied by our team in two rat models:the sciatic nerve crush and the Charcot-Marie-Tooth-1A disease.In this study,we sought to highlig...
关键词:Charcot-Marie-Tooth-1A endoplasmic reticulum Gene Ontology NEUROGENESIS oxidative stress PROTEOMICS rat repair sciatic nerve crush SWATH-MS 
Bioinformatics analysis of ferroptosis in spinal cord injury被引量:13
《Neural Regeneration Research》2023年第3期626-633,共8页Jin-Ze Li Bao-You Fan Tao Sun Xiao-Xiong Wang Jun-Jin Li Jian-Ping Zhang Guang-Jin Gu Wen-Yuan Shen De-Rong Liu Zhi-Jian Wei Shi-Qing Feng 
supported by National Key Research and Development Project of Stem Cell and Transformation Research,No.2019YFA0112100;Tianjin Key Research and Development Plan,Key Projects for Science and Technology Support,No.19YFZCSY00660(both to SQF)。
Ferroptosis plays a key role in aggravating the progression of spinal cord injury(SCI),but the specific mechanism remains unknown.In this study,we constructed a rat model of T10 SCI using a modified Allen method.We id...
关键词:bioinformatics drug ferroptosis Gene Ontology enrichment analysis gene-miRNA network Kyoto Encyclopedia of Genes and Genomes pathway mRNA-miRNA-lncRNA network progression spinal cord injury 
A comparative analysis of differentially expressed genes in rostral and caudal regions after spinal cord injury in rats
《Neural Regeneration Research》2022年第10期2267-2271,共5页Xue-Min Cao Sheng-Long Li Yu-Qi Cao Ye-Hua Lv Ya-Xian Wang Bin Yu Chun Yao 
supported by Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX-2065(to XMC).
The initial mechanical damage of a spinal cord injury(SCI)triggers a progressive secondary injury cascade,which is a complicated process integrating multiple systems and cells.It is crucial to explore the molecular an...
关键词:biological process CAUDAL differentially expressed genes Gene Ontology HEMISECTION IMMUNOSTAINING Rattus norvegicus RNA-sequencing rostral spinal cord injury 
Expression and regulatory network of long noncoding RNA in rats after spinal cord hemisection injury被引量:2
《Neural Regeneration Research》2022年第10期2300-2304,共5页Wei Liu Jin-Cheng Tao Sheng-Ze Zhu Chao-Lun Dai Ya-Xian Wang Bin Yu Chun Yao Yu-Yu Sun 
Long noncoding RNAs(lncRNAs)participate in a variety of biological processes and diseases.However,the expression and function of lncRNAs after spinal cord injury has not been extensively analyzed.In this study of righ...
关键词:bioinformatic analysis biological process gene ontology analysis inflammatory response Kyoto encyclopedia of genes and genomes analysis long noncoding RNAs regulatory network RNA sequencing spinal cord injury synaptic transmission 
Gene and protein expression profiles of olfactory ensheathing cells from olfactory bulb versus olfactory mucosa被引量:1
《Neural Regeneration Research》2022年第2期440-449,共10页Yuan-Xiang Lan Ping Yang Zhong Zeng Neeraj Yadav Li-Jian Zhang Li-Bin Wang He-Chun Xia 
supported by Key Research Projects of Ningxia Hui Autonomous Region of China,No.2018BCG01002(to HCX);the Natural Science Foundation of Ningxia Hui Autonomous Region of China,No.NZ17150(to PY)。
Olfactory ensheathing cells(OECs) from the olfactory bulb(OB) and the olfactory mucosa(OM) have the capacity to repair nerve injury. However, the difference in the therapeutic effect between OB-derived OECs and OM-der...
关键词:biological process cellular component GENE Gene Ontology Kyoto Encyclopedia of Genes and Genomes molecular function olfactory bulb olfactory ensheathing cells olfactory mucosa PROTEIN 
MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing被引量:7
《Neural Regeneration Research》2021年第10期2099-2108,共10页Li Zeng Hai-Lun Jiang Ghulam Md Ashraf Zhuo-Rong Li Rui Liu 
This study was supported by the National Natural Science Foundation of China(General Program),No.81673411;the United Fund Project of National Natural Science Foundation of China,No.U1803281;Young Medical Talents Award Project of Chinese Academy of Medical Sciences,No.2018RC350013;Chinese Academy of Medical Sciences Innovation Project for Medical Science,No.2017-I2M-1-016(all to RL).
In a previous study,we found that long non-coding genes in Alzheimer’s disease(AD)are a result of endogenous gene disorders caused by the recruitment of microRNA(miRNA)and mRNA,and that miR-200a-3p and other represen...
关键词:3ʹ-untranslated region Alzheimer’s disease BIOMARKER cerebral cortex Gene Ontology high-throughput sequencing intracellular neurofibrillary tangles microtubule-associated protein-τ miRNA-mRNA network presenilin 1 
Bioinformatic analysis of cytokine expression in the proximal and distal nerve stumps after peripheral nerve injury被引量:1
《Neural Regeneration Research》2021年第5期878-884,共7页Xiao-Qing Cheng Wen-Jing Xu Xiao Ding Gong-Hai Han Shuai Wei Ping Liu Hao-Ye Meng Ai-Jia Shang Yu Wang Ai-Yuan Wang 
This study was supported by the National Natural Science Foundation of China,No.31771052(to YW);the National Key R&D Program of China,No.2017YFA0104702(to AJS);the Youth Cultivation Project of Military Medical Science,No.16QNP144(to YW).
In our previous study,we investigated the dynamic expression of cytokines in the distal nerve stumps after peripheral nerve injury using microarray analysis,which can characterize the dynamic expression of proteins.In...
关键词:cytokine distal stumps Gene Ontology Kyoto Encyclopedia of Genes and Genomes Pathway microarray microenvironment peripheral nerve injury proximal stumps 
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