GENE_POLYMORPHISMS

作品数:258被引量:907H指数:14
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相关作者:王增军王涛张炜李琼芳陈常中更多>>
相关机构:江苏省人民医院甘肃省肿瘤医院第二军医大学重庆医科大学附属第一医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家高技术研究发展计划更多>>
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  • 期刊=Neural Regeneration Researchx
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Differences in brain-derived neurotrophic factor gene polymorphisms between acute ischemic stroke patients and healthy controls in the Han population of southwest China被引量:7
《Neural Regeneration Research》2019年第8期1404-1411,共8页Jie Zhou Meng-Meng Ma Jing-Huan Fang Lei Zhao Mu-Ke Zhou Jian Guo Li He 
supported by the National Natural Science Foundation of China,No.81472162(to MKZ)
Single-nucleotide polymorphisms in the brain-derived neurotrophic factor gene may affect the secretion and function of brain-derived neurotrophic factor, thereby affecting the occurrence, severity and prognosis of isc...
关键词:nerve REGENERATION ischemic STROKE BRAIN-DERIVED NEUROTROPHIC factor single-nucleotide polymorphism risk STROKE severity prognosis rs6265 rs7124442 neural REGENERATION 
Associations between thromboxane A synthase 1 gene polymorphisms and the risk of ischemic stroke in a Chinese Han population被引量:6
《Neural Regeneration Research》2018年第3期463-469,共7页Lei Li Zhi-yi He Yan-zhe Wang Xu Liu Li-ying Yuan 
supported by a grant from the National Natural Science Foundation of China,No.81070913
Thromboxane A synthase 1 (TBXAS1) catalyses the synthesis of thromboxane A2 (TXA2), which plays an important role in the pathogenesis of ischemic stroke. Thus, the TBXAS1 gene was investigated as a candidate gene ...
关键词:nerve regeneration brain injury ischemic stroke thromboxane A synthase 1 single nucleotide polymorphism case-control study thromboxane A2 Chinese Han population HAPLOTYPE large-artery atherosclerosis small-artery occlusion neural regeneration 
DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children被引量:3
《Neural Regeneration Research》2017年第2期259-266,共8页Yun Chen Hua Zhao Yi-xin Zhang Peng-xiang Zuo 
funded by the National Natural Science Foundation of China,No.81360434
Developmental dyslexia is a complex reading and writing disorder with strong genetic components. In previous genetic studies about dyslexia, a number of candidate genes have been identified. These include DCDC2, which...
关键词:nerve regeneration developmental dyslexia single nucleotide polymorphisms Xinjiang Uyghur Autonomous Region elementary school students genetics reading disability gene polymorphisms etiology case-control study neural regeneration 
Correlating interleukin-10 promoter gene polymorphisms with human cerebral infarction onset被引量:7
《Neural Regeneration Research》2015年第11期1809-1813,共5页Xin-hong Jiang Ke-xu Lin Yi-xian Zhang Rong-hua Chen Nan Liu 
supported by the National Natural Science Foundation of China;No.81171867;a grant from the Key Research Program of Fujian Department of Science and Technology of China;No.2011Y0027
Evidence suggests that interleukin-10(IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites-1082(A/G) and-819...
关键词:neural regeneration IL-IO PROMOTER gene polymorphisms ischemic stroke geneticsusceptibility inflammation immune response ischemia/ reperfusion injury neural regeneration 
APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease被引量:4
《Neural Regeneration Research》2014年第6期653-660,共8页Qin Zhou Dantao Peng Xinrui Yuan Zeping Lv Shenghang Pang Wenyu Jiang Chuyu Yang Xiaohong Shi Guofang Pang Yige Yang Haiqun Xie Wandong Zhang Caiyou Hu Ze Yang 
supported by the National Natural Science Foundation of China,No.81370445,81061120527,81241082;Major Funding from Beijing Hospital,No.BJ-2010-30;Key Project of Clinical Disciplines at the Subordinate Hospital,Ministry of Health,No.10120101;National Department Public Benefit Research Foundation by the Ministry of Health,No.201302008;12th 5-year National Program from Ministry of Scientific Technology,No.2012BAI10B01;Science and Technology Development Foundation of Guangxi Zhuang Autonomous Region,No.1355005-62;Canadian Institute of Health Research(CIHR),No.109606
Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it re...
关键词:nerve degeneration cognitive disorders DEMENTIA Alzheimer's disease polymorphism apolipoprotein E apolipoprotein CI low density lipoprotein receptor-related protein NSFC grant neural regeneration 
A non-invasive,rapid method to genotype late-onset Alzheimer's disease-related apolipoprotein E gene polymorphisms被引量:1
《Neural Regeneration Research》2014年第1期69-75,共7页Li Yi Ting Wu Wenyuan Luo Wen Zhou Jun Wu 
supported by two grants from Science,Industry,Trade and Information Technology Commission of Shenzhen Municipality in China,grant No.201002063,JC20110518075 7A
The apolipoprotein E gene ε4 allele is considered a negative factor for neural regeneration in late-onset Alzheimer's disease cases. The aim of this study was to establish a non-invasive, rapid method to genotype ap...
关键词:nerve regeneration NEURODEGENERATION late-onset Alzheimer's disease apolipoprotein Egene real-time PCR DNA sequencing risk factor ALLELE neural regeneration 
Association of glutathione S-transferase T1 and M1 gene polymorphisms with ischemic stroke risk in the Chinese Han population被引量:1
《Neural Regeneration Research》2012年第18期1420-1427,共8页Rui Wang Yan Wang Junhong Wang Kun Yang 
Atherosclerosis plays an important role in ischemic stroke, and oxidative stress participates in the entire process of atherosclerosis. Glutathione S-transferase (GST) acting with other antioxidant enzymes can elimi...
关键词:glutathione S-transferase GSTT1 GSTM1 gene polymorphism ischemic stroke risk factors stroke neural regeneration 
Association between AKT1 gene polymorphisms and depressive symptoms in the Chinese Han population with major depressive disorder被引量:10
《Neural Regeneration Research》2012年第3期235-239,共5页Chunxia Yang Ning Sun Yan Ren Yan Sun Yong Xu Aiping Li Kewen Wu Kerang Zhang 
supported by grants from the National Natural Science Foundation of China, No. 30770770,30971054;Personnel Returned Overseas Research Foundation of Shanxi Province, No. 2007-48;Science Foundation for Youths of Shanxi Province, No. 2010021036-3;the Special Fund Talent of Shanxi Province, Foundation for Youths of Shanxi Province, No. 2011021036-1
For this study, 461 Chinese Han patients with depressive disorder were recruited. The AKT1 genotype and allele distribution were determined by PCR amplification and direct sequencing. UNPHASED software was used to ana...
关键词:AKT1 major depression SYMPTOMS POLYMORPHISM neural regeneration 
Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis被引量:46
《Neural Regeneration Research》2011年第22期1731-1735,共5页Qingli Sun Yu Fu Aping Sun Yanhong Shou Mei Zheng Xiaogang Li Dongsheng Fan 
OBJECTIVE: To investigate the association of E-selectin $128R polymorphisms with ischemic stroke. DATA SOURCES: A computer-based online search was conducted in PubMed, Elsevier, Ovid Database, the China National Kno...
关键词:E-SELECTIN ischemic stroke gene POLYMORPHISM META-ANALYSIS 
Association between serotonin transporter gene polymorphisms and non-lesional temporal lobe epilepsy in a Chinese Han population
《Neural Regeneration Research》2010年第16期1270-1273,共4页Fengyuan Che Youyi Wei Xueyuan Heng Qingxi Fu Jianzhang Jiang 
Serotonin (5-hydroxytryptamine, 5-HT) influences the cortical and subcortical excitatory/inhibitory balance and participates in the pathophysiological processes of epilepsy. The serotonin transporter (5-HTT) is th...
关键词:serotonin transporter gene-linked polymorphic region serotonin transporter intron 2 variable number tandem repeat POLYMORPHISM temporal lobe epilepsy neural regeneration 
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