GENE_SILENCING

作品数：162被引量：627H指数：11
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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease
《Neural Regeneration Research》2025年第9期2538-2555,共18页Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren 
supported by Open Project of the Key Laboratory of Trauma and Orthopedics Research Medicine in Henan Province,No.HZKFKT20220504(to YZ);the National Natural Science Foundation of China,No.32000877(to YZ);and Open Scientific Research Program of Military Logistics,No.BLB20J009(to YZ)。
Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive defi...
关键词：blood-brain barrier cognitive dysfunction EXOSOMES gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles NEUROINFLAMMATION polymer nanoparticles stem cells 
Nanotechnology-based gene therapy as a credible tool in the treatment of Alzheimer’s disease被引量：5
《Neural Regeneration Research》2023年第10期2127-2133,共7页Aziz Unnisa Nigel H.Greig Mohammad Amjad Kamal 
supported by the Intramural Research Program National Institute on Aginq,NIH。
Toxic aggregated amyloid-βaccumulation is a key pathogenic event in Alzheimer’s disease.Treatment approaches have focused on the suppression,deferral,or dispersion of amyloid-βfibers and plaques.Gene therapy has ev...
关键词：Alzheimer’s disease amyloid-β BACE1 gene silencing gene therapy nanoparticle NEUROTROPHINS small interfering ribonucleic acid 
Aquaporin-4 gene silencing protects injured neurons after early cerebral infarction被引量：9
《Neural Regeneration Research》2015年第7期1082-1087,共6页Zhan-ping He Hong Lu 
supported by the National Natural Science Foundation of China,No.30960399;a grant from Hainan Provincial International Cooperation Project of China,No.Qiongke(2012)65;a grant from Hainan Provincial Health Department Project of China,No.2011-SWK-10-136/Qiongwei2011-65
Aquaporin-4 regulates water molecule channels and is important in tissue regulation and water transportation in the brain. Upregulation of aquaporin-4 expression is closely related to cellular edema after early cerebr...
关键词：nerve regeneration middle cerebral artery occlusion cerebral ischemia cytotoxic edema angioedema magnetic resonance imaging diffusion-weighted imaging aquaporin-4 gene silencing 
Chemokine receptor 4 gene silencing blocks neuroblastoma metastasis in vitro被引量：4
《Neural Regeneration Research》2014年第10期1063-1067,共5页Xin Chen Yongjie Zhu Lulu Han Hongting Lu Xiwei Hao Qian Dong 
supported by the National Natural Science Foundation of China,No.81272986;the Natural Science Foundation of Shandong Province,No.ZR2011HZ002
This study investigated the effects of small interfering RNA （siRNA）-mediated silencing of chemokine receptor 4 （CXCR4） on the invasion capacity of human neuroblastoma cell line SH-SY5Y in vitro. Three siRNAs targ...
关键词：nerve regeneration chemokine receptor 4 small interfering RNA NEUROBLASTOMA inva-sion Transwell chamber LIPOSOME NSFC grant neural regeneration 
Bone marrow mesenchymal stem cells with Nogo-66 receptor gene silencing for repair of spinal cord injury被引量：5
《Neural Regeneration Research》2014年第8期806-814,共9页Zhiyuan Li Zhanxiu Zhang Lili Zhao Hui Li Suxia Wang Yong Shen 
We hypothesized that RNA interference to silence Nogo-66 receptor gene expression in bone marrow mesenchymal stem cells before transplantation might further improve neurological function in rats with spinal cord trans...
关键词：nerve regeneration spinal cord injury bone marrow mesenchymal stem cells Nogo-66receptor RNA interference horseradish peroxidase BRDU gene silencing neural regeneration 
Transplantation of Nogo-66 receptor gene-silenced cells in a poly(D,L-lactic-co-glycolic acid) scaffold for the treatment of spinal cord injury被引量：8
《Neural Regeneration Research》2013年第8期677-685,共9页Dong Wang Yuhong Fan Jianjun Zhang 
sponsored by the Science and Technology Foundation of Tianjin Health Bureau,No. 2010ky04;the Application Basis and Front Technology Projects of Tianjin (Science and Technology Foundation of Tianjin),No.12JCYBJC18000
Inhibition of neurite growth, which is in large part mediated by the Nogo-66 receptor, affects neural regeneration following bone marrow mesenchymal stem cell transplantation. The tissue engineering scaffold poly（D,L...
关键词：neural regeneration spinal cord injury bone marrow mesenchymal stem cells Schwann cells poly（D L-lactide-co-glycolic acid） Nogo-66 receptor gene rats gene silencing grants-supportedpaper photographs-containing paper neuroregeneration 
Gene interference regulates aquaporin-4 expression in swollen tissue of rats with cerebral ischemic edema Correlation with variation in apparent diffusion coefficient被引量：14
《Neural Regeneration Research》2012年第21期1659-1666,共8页Hui Hu Hong Lu Zhanping He Xiangjun Han Jing Chen Rong Tu 
supported by the National Natural Science Foundation of China, No. 30960399, 81160181
To investigate the effects of mRNA interference on aquaporin-4 expression in swollen tissue of rats with ischemic cerebral edema, and diagnose the significance of diffusion-weighted MRI, we injected 5 pL shRNA- aquapo...
关键词：cerebral ischemic edema magnetic resonance imaging diffusion gene silencing AQUAPORIN-4 mRNA interference neural regeneration 
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