the National Natural Science Foundation of China, No. 30772341, 81070523
We constructed a lentiviral vector carrying vascular endothelial growth factor 165, which was used to transfect neural stem cells. The transfection rate was approximately 50%, as determined by flow cytometry. Vascular...
the National Natural Science Foundation of China,No.30570626;the Natural Science Foundation of Beijing,No.7082028
BACKGROUND: The transcription factor Oligl is required for oligodendrocyte maturation and demyelinated lesion repair, and is a key regulator of myelinogenesis following ischemia. OBJECTIVE: To examine the efficacy o...
Supported by: the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China, No. D002006006
BACKGROUND: Recent findings have demonstrated that the kallikrein-kinin system (KKS) participates in the pathological process of cerebral ischemia/reperfusion injury. Kallikrein gene transfer exhibits neural protec...
the Foundation of High-Tech Key Project of the National 863 Program, No. 2001AA217061
BACKGROUND: Recent advancements in gene therapy have provided new methodology for treating ischemia in lower extremities. Gene transfer of angiogenic factors to ischemic tissues may promote local proliferation of new...
Key Program of Chongqing Municipal Health Bureau,No. 06-01-020
BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) accumulates under conditions of hypoxia. HIF-1α target genes have pleiotropic effects on neurogenesis, neuroprotection and angiogenesis in the brain. OBJECTIVE: To i...