HEPATIC_STELLATE_CELL

作品数：134被引量：1052H指数：19
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Luteolin-7-diglucuronide,a novel PTP1B inhibitor,ameliorates hepatic stellate cell activation and liver fibrosis in mice
《Acta Pharmacologica Sinica》2025年第1期122-133,共12页Bi-xi Tang Yong Zhang Dan-dan Sun Qin-yi Liu Cong Li Pei-pei Wang Li-xin Gao Xue-mei Zhang Jia Li Wei-liang Zhu Yi Zang 
This article was supported by Shanghai lnstitute of Materia Medica,Chinese Academy of Sciences(No.CASIMM0120225006-2,SIMM0120232001);Shanghai Municipal Science and Technology Major Project(TM202301H002);Shanghai Committee of Science and Technology(22ZR1415200).
Liver fibrosis,one of the leading causes of morbidity and mortality worldwide,lacks effective therapy.The activation of hepatic stellate cells(HSCs)is the dominant event in hepatic fibrogenesis.Luteolin-7-diglucuronid...
关键词：liver fibrosis PHYTOCHEMICAL luteolin 7-diglucuronide HSC activation PTP1B 
Engineered SPIONs functionalized with endothelin a receptor antagonist ameliorate liver fibrosis by inhibiting hepatic stellate cell activation被引量：1
《Bioactive Materials》2024年第9期406-426,共21页Marit ten Hove Andreas Smyris Richell Booijink Lydia Wachsmuth Uwe Hansen Lejla Alic Cornelius Faber Carsten Hӧltke Ruchi Bansal 
Endothelin-1/endothelin A receptor(ET-1/ETAR)pathway plays an important role in the progression of liver fibrosis by activating hepatic stellate cells(HSCs)-a key cell type involved in the pathogenesis of liver fibros...
关键词：Endothelin A receptor SPIONs Hepatic stellate cells Liver fibrosis 
MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第7期594-604,共11页Yanjin WANG Yifei CHEN Fuji YANG Xiaolong YU Ying CHU Jing ZHOU Yongmin YAN Jianbo XI 
supported by the National Natural Science Foundation of China(No.82272421);the Jiangsu Provincial Key Research and Development Program(No.BE2021690);the Changzhou's 14th Five-year Plan Project to Train Highlevel Health Professionals(No.2022CZLJ027);the Scientific Project of Jiangsu Health Commission(No.Z2020038);the Changzhou Sci&Tech Program(No.CJ20220164),China.
Liver fibrosis is a significant health burden,marked by the consistent deposition of collagen.Unfortunately,the currently available treatment approaches for this condition are far from optimal.Lysyl oxidase-like prote...
关键词：Mesenchymal stem cell(MSC) Small extracellular vesicle(sEV) MicroRNA-4465(miR-4465) Hepatic stellate cell(HSC) Liver fibrosis 
Picroside Ⅱ promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2^(−/−)mice by polarizing M1 macrophages and balancing immune responses
《Chinese Journal of Natural Medicines》2024年第7期582-598,共17页JIA Kexin MA Zhi ZHANG Yinhao XIE Kaihong LI Jianan WU Jianzhi QU Jiaorong LI Fanghong LI Xiaojiaoyang 
supported by the National Key Research and Development Program on Modernization of Traditional Chinese Medicine(No.2022YFC3502100);the National Natural Science Foundation of China(No.82274186);the National High-Level Talents Special Support Program;the Young Talents Promotion Project of China Association of Traditional Chinese Medicine(No.2020-QNRC2-01);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006).
Liver fibrosis is characterized by chronic inflammatory responses and progressive fibrous scar formation.Macrophages play a central role in the pathogenesis of hepatic fibrosis by reconstructing the immune microenviro...
关键词：Liver fibrosis PicrosideⅡ M1 macrophage Hepatic stellate cell Natural killer cell NEUTROPHIL 
Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis被引量：1
《Journal of Pharmaceutical Analysis》2024年第5期744-757,共14页Lifan Lin Xinmiao Li Yifei Li Zhichao Lang Yeping Li Jianjian Zheng 
supported by Wenzhou Municipal Science and technology Bureau,China(Grant No.:Y20220023);the Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province,China(Grant No.:2022E10022);the Project of Wenzhou Medical University Basic Scientific Research,China(Grant No.:KYYW201904).
Liver fibrosis is primarily driven by the activation of hepatic stellate cells(HSCs),a process associated with ferroptosis.Ginsenoside Rb1(GRb1),a major active component extracted from Panax ginseng,inhibits HSC activ...
关键词：Ginsenoside Rb1 Ferroptosis Liver fibrosis Hepatic stellate cells 
Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation
《Journal of Integrative Medicine》2024年第2期188-198,共11页Meng Li Yang Zhou Hui Zhu Lie-ming Xu Jian Ping 
supported by grants from the National Natural Science Foundation of China(No.81773980);Project of Science and Technology Commission of Shanghai Municipality(No.15401902600)。
Objective:This study explores the mechanism of action of Danhongqing formula(DHQ),a compoundbased Chinese medicine formula,in the treatment of cholestatic liver fibrosis.Methods:In vivo experiments were conducted usin...
关键词：Liver cirrhosis BILIARY Long non-coding RNA H19 Danhongqing formula CHOLANGIOCYTE Hepatic stellate cells STAT3 transcription factor 
Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease
《Animal Models and Experimental Medicine》2024年第2期166-178,共13页Xuecui Yin Lin Dong Xiaohan Wang Zhenzhen Qin Yuying Ma Xiaofei Ke Ya Li Qingde Wang Yang Mi Quanjun Lyu Xia Xu Pengyuan Zheng Youcai Tang 
Discipline Key Special Project;Grant/Award Number:XKZDQY202001;Henan Provincial Key R&D and Promotion Special Project;Grant/Award Number:212102310033;Henan Provincial Medical Science and Technology Tackling Program;Grant/Award Number:LHGJ20220557;Key R&D Program of China;Grant/Award Number:2020YFC2006100,2020YFC2009000 and 2020YFC2009006;National Natural Science Foundation of China;Grant/Award Number:31471330 and 81870408。
Background:Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases globally.Hepatic stellate cells(HSCs)are the major effector cells of liver fibrosis.HSCs contain abundant lipid drople...
关键词：AMPK APOPTOSIS hepatic stellate cell liver fibrosis perilipin 5 
Linking fatty liver diseases to hepatocellular carcinoma by hepatic stellate cells
《Journal of the National Cancer Center》2024年第1期25-35,共11页Liang’en Chen Xiangshi Ye Lixian Yang Jiangsha Zhao Jia You Yuxiong Feng 
supported by grants from the Ministry of Science and Technology of the People’s Republic of China(grant number:2020YFA0803300);the National Natural Science Foundation of China(grant numbers:32270783,32100949,32300642);Figures were prepared using Figdraw。
Hepatic stellate cells(HSCs),a distinct category of non-parenchymal cells in the liver,are critical for liver homeostasis.In healthy livers,HSCs remain non-proliferative and quiescent.However,under conditions of acute...
关键词：Hepatic stellate cell Fatty liver disease Hepatocellular carcinoma Liver fibrosis 
The effect and application of adiponectin in hepatic fibrosis
《Gastroenterology Report》2024年第1期772-783,共12页Taoran Chen Wenjing Yang Rongrong Dong Han Yao Miao Sun Jiaxin Wang Qi Zhou Jiancheng Xu 
supported by the Project of the Jilin Science and Technology Development Program[20220401085YY].
Hepatic fibrosis,a degenerative liver lesion,significantly contributes to the deterioration and mortality among patients with chronic liver diseases.The condition arises from various factors including toxins,such as a...
关键词：ADIPONECTIN hepatic fibrosis CIRRHOSIS endoplasmic reticulum stress hepatic stellate cell 
Role of Exosomal Modulation of Macrophages in Liver Fibrosis
《Journal of Clinical and Translational Hepatology》2024年第2期201-209,共9页Bin Fan He Xie Qi Tan Qingyuan Li Tao Gong Baoren He Yujia Li Limin Chen 
CAMS Initiative for Innovative Medicine:CAMS-2021-I2M-1-060;National Key Research and Development Program of China:2018YFE0107500;Science and Technology Partnership Program,Ministry of Science and Technology of China:KY201904011;Qin Chuang Yuan recruited highlevel innovation and entrepreneurship talents project of Science and Technology Department of Shaanxi Province:QCYRCXM-2022-56;Foreign Expert Service Project of Science and Technology Department of Shaanxi Province:2023 WGZJ-YB-39;Medical Research project of Xi’an Science and Technology Bureau:22YXYJ0120.
Exosomes are 60–120 nm diameter double-membrane lipid organelles discharged by cells.Various studies have shown that exosomes exert multiple functions in both physical and diseased processes,such as intercellular inf...
关键词：EXOSOME Macrophage Liver fibrosis HEPATOCYTE Mesenchymal stem cell Hepatic stellate cell 
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