HERPES

作品数：143被引量：222H指数：7
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Effect of Loss-of-function of the Herpes Simplex Virus-1 microRNA H6-5p on Virus Replication被引量：1
《Virologica Sinica》2019年第4期386-396,共11页Rongquan Huang Xusha Zhou Shuqi Ren Xianjie Liu Zhiyuan Han Grace Guoying Zhou 
supported by grants from Shenzhen Science and Innovation Commission Project Grants JCYJ20170411094933148;Dapeng Research Project Grants KY20160301 to Shenzhen International Institute for Biomedical Research;Guangzhou Science and Innovation Commission Project Grants 2016070100039;Guangzhou Education Bureau Project Grants 1201620034 to Guangzhou Medical University
To date, 29 distinct microRNAs(miRNAs) have been reported to be expressed during herpes simplex virus infections.Sequence analysis of mature herpes simplex virus-1(HSV-1) miRNAs revealed five sets of miRNAs that are c...
关键词：miR-H6-5p miR-H1-3p SPONGE Replication HERPES SIMPLEX virus-1(HSV-1) 
HSV-2-encoded miRNA-H4 Regulates Cell Cycle Progression and Act-Dinduced Apoptosis in HeLa Cells by Targeting CDKL2 and CDKN2A被引量：1
《Virologica Sinica》2019年第3期278-286,共9页Yang Zhao Jingjing Yang Yan Liu Jianyong Fan Huilan Yang 
supported by the National Natural Science Foundation of China (81371749) and (81171511)
MicroRNAs(miRNAs)encoded by latency-associated transcript are associated with both latent and acute stages of herpes simplex virus 2(HSV-2)infection.In this study,miRNA-H4-5p and miRNA-H4-3p were ectopically expressed...
关键词：HERPES SIMPLEX virus 2(HSV-2) MicroRNAs(miRNAs) Anti-apoptosis-Cell cycle progression Pathogen-host interaction 
Inhibition of Herpes Simplex Virus-1 Replication by Natural Compound Honokiol被引量：4
《Virologica Sinica》2019年第3期315-323,共9页Shuai Liu Long Li Lingbing Tan Xiaozhen Liang 
supported by the grant from National Key Research and Development Program (2016YFA0502100)
Honokiol is a pleiotropic natural compound isolated from Magnolia and has multiple biological and clinically relevant effects,including anticancer and antimicrobial function.However,the antiviral activity of honokiol ...
关键词：HONOKIOL HERPES simplex virus-1(HSV-1) Viral REPLICATION ANTI-VIRAL activity ACYCLOVIR 
Remodeling of host membranes during herpesvirus assembly and egress被引量：1
《Protein & Cell》2019年第5期315-326,共12页Ying Lv Sheng Zhou Shengyan Gao Hongyu Deng 
the Ministry of Science and Technology(National Key R&D Program of China,No.2016YFA0502101);the National Natural Science Foundation of China(No.81630059 and 81325012).
Many viruses,enveloped or non-enveloped,remodel host membrane structures for their replication,assembly and escape from host cells.Herpesviruses are important human pathogens and cause many diseases.As large enveloped...
关键词：HERPESVIRUSES assembly EGRESS BUDDING fusion MEMBRANE deformations 
Detection of EBV and HHV6 in the Brain Tissue of Patients with Rasmussen's Encephalitis被引量：6
《Virologica Sinica》2018年第5期402-409,共8页Dong Liu Xin Wang Yisong Wang Peigang Wang Dongying Fan Sichang Chen Yuguang Guan Tianfu Li Jing An Guoming Luan 
supported by the National Natural Science Foundation of China(81701992,81471957,and 81671971);the Beijing Municipal Natural Science Foundation(7144217);the Capital Applied Clinic Research Programs of Science and Technology(Z131107002213171);the Beijing Rising-star Plan of Science and Technology(Z141107001814042);Scientific Research Common Program of Beijing Municipal Commission of Education(KM201610025001)
Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this s...
关键词：Rasmussen’s ENCEPHALITIS (RE) Epstein-Barr VIRUS (EBV) Human HERPES VIRUS 6 (HHV6) Seizures CD8^+T cells 
FDA批准美国首个溶瘤病毒疗法
《当代化工》2015年第10期2394-2394,共1页
10月27日,美国食品药品监督局（FDA）发文称,已经批准安进（Amgen）的溶瘤病毒疗法（oncolytic virus therapy）用于治疗病灶在皮肤和淋巴结,没能通过手术完全清除的黑色素瘤。该药物名字叫Imlygic（talimogene laherparepvec;T-VEC）,...
关键词：溶瘤病毒 FDA SIMPLEX 药品监督局 黑色素瘤 HERPES 单纯疱疹病毒 基因改造 恶性神经胶质瘤 霍奇金病 
In vitro Anti-viral Activity of the Total Alkaloids from Tripterygium hypoglaucum against Herpes Simplex Virus Type 1被引量：7
《Virologica Sinica》2010年第2期107-114,共8页Zhe REN Chuan-hai ZHANG Lian-jun WANG Yun-xia CUI Ren-bin QI Chong-ren YANG Ying-jun ZHANG Xiao-yi WEI Da-xiang LU Yi-fei WANG 
The Joint Funds of National Science Foundation of China (U0632010);The State Key Laboratory of Phytochemistry and Plant Resources in West China;Chinese Academy of Sciences (O807B11211, O807E21211);"211 grant of MOE"
Herpes simplex virus type 1 （HSV-1） is a commonly occurring human pathogen worldwide. There is an urgent need to discover and develop new alternative agents for the management of HSV-1 infection. Tripterygium hypogl...
关键词：Tripterygium hypoglaucum Herpes complex virus ALKALOID Antiviral activity Gene expression 
Transcriptional regulation of the Herpes Simplex Virus 1α-gene by the viral immediate-early protein ICP22 in association with VP16被引量：4
《Science China(Life Sciences)》2009年第4期344-351,共8页CUN Wei, GUO Lei, ZHANG Ying, LIU LongDing, WANG LiChun, LI JianFeng, DONG ChengHong, WANG JinJin & LI QiHan Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China 
Supported by the National Natural Science Foundation (Grant No. 30570081, 30670094);Doctoral Fund of Ministry of Education of China (Grant No. 20060023053)
Herpes Simplex Virus 1 (HSV1) is capable of inducing two forms of infection in individuals, and the establishment of which type of infection occurs is linked to the transcriptional activation of viral α genes. One of...
关键词：HERPES SIMPLEX virus ICP22 transcription VP16 α GENE 
The Importance of Heparan Sulfate in Herpesvirus Infection被引量：3
《Virologica Sinica》2008年第6期383-393,共11页Christopher D. O'Donnell Deepak Shukla 
NIH grant (AI 057860 to D.S)
Herpes simplex virus type-1 (HSV-1) is one of many pathogens that use the cell surface glycosaminoglycan heparan sulfate as a receptor. Heparan sulfate is highly expressed on the surface and extracellular matrix of vi...
关键词：Heparan sulfate （HS） HERPESVIRUSES Herpes simplex virus type-1 （HSV-1） 3-O-sulfotransferases Viral entry 
Functional analysis of transcriptional regulation of herpes simplex virus type 1 tegument protein VP22被引量：4
《Science China(Life Sciences)》2008年第11期966-972,共7页YU Xian1,2, LI WeiZhong1, LIU LongDing1, CHE YanChun1, CUN Wei1, WU WenJuan1, HE ChunYan1, SHAO CongWen1 & LI QiHan1 1 Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China 2 Institute of Materia Medica, North Sichuan Medical College, Nanchong 637007, China 
the National Natural Science Foundation of China (Grant Nos. 30570081,30670094 and 30700028)
The herpes simplex virus type 1 (HSV-1) tegument proteins have important functions in the viral repli- cation process. In order to investigate the role of the HSV-1 tegument protein VP22 in viral replication, its tran...
关键词：HERPES SIMPLEX virus type 1 TEGUMENT VP22 TRANSCRIPTIONAL regulation 
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