the National Natural Science Foundation of China(No.81902016).
Objective The activation state of microglia is known to occupy a central position in the pathophysiological process of cerebral inflammation.Autophagy is a catabolic process responsible for maintaining cellular homeos...
We acknowledge all members of the Milpied and Vivier laboratories at CIML for fruitful discussions;EP is supported by a fellowship funded by Innate Pharma and the RHU PIONeeR project(ANR-17-RHUS-00XX-08);This work was supported by grants from ITMO Cancer and the RHU PIONeeR project.
B cells play essential roles in immunity,mainly through the production of high affinity plasma cells(PCs)and memory B(Bmem)cells.The affinity maturation and differentiation of B cells rely on the integration of B-cell...
When am I ever going to use this?TRACK AND FIELDThe 100-meter dash features 20 runners competing in a preliminary round of 4 heats.The winner of each heat advances to the final race.Before the race,each runner chooses...
We study the law of the iterated logarithm (LIL) for the maximum likelihood estimation of the parameters (as a convex optimization problem) in the generalized linear models with independent or weakly dependent (ρ-mix...
This work was supported by the National Major Scientific and Technological Special Project for‘Significant New Drugs Development’(2018ZX09733001);the National Key Research and Development Program of China(2016YFA0201402);and National Natural Science Foundation Regional Irmovation and Development(U19A2003).;The authors would like to thank Wen Nie and Min Luo for their assistance with the manuscript preparation.
Necrosis,a type of unwanted and passive cell demise,usually occurs under the excessive external stress and is considered to be unregulated.However,under some special conditions such as caspase inhibition,necrosis is r...
Objective:The role of intestine-derived factors in promoting liver regeneration after partial hepatectomy(PHx)are not entirely known,but bile acids(BAs)and fibroblast growth factor 15(Fgf15)that are highly expressed i...
This project is supported by the National Basic Research Program(973)of China(No.2013CB967202);the National Natural Science Foundation of China(No.81273331);the National Natural Science Foundation of China(No.81470354);National Natural Science Foundation of China(81301856;NL).
TIFA,also called T2BP,was first identified using yeast two-hybrid screening.Our previous work showed that TIFA suppresses hepatocellular carcinoma(HCC)progression via apoptosis and cell cycle arrest.However,the mechan...
In the present study, we aimed to determine the quality of different brands(Test1–Test6) of mefenamic acid, which are commercially available in local market of Karachi, Pakistan. Various quality evaluation tests, inc...
Background: Although the onset of anemia during infectious disease is commonly correlated with production of inflammatory cytokines, the mechanisms by which cytokines induce anemia are poorly defined. This study focu...
financially supported by the Public Science and Technology Funds for Ocean Projects(Grant nos.201005032-2 and 201205020-5);by the Special Funds for Basic Scientific Research by Central Non-profit Institutes(Grant no.GY02-2012G14)
Bacterial diversity in surface sediment from the Arctic Ocean was investigated by culture-dependent and-independent approaches. Conventional culture-dependent techniques revealed 11 strains based on their distinct mor...