ISCHEMIC_STROKE

作品数：655被引量：2857H指数：25
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Can NogoA Be a Suitable Target to Treat Ischemic Stroke?
《Neuroscience Bulletin》2024年第4期557-560,共4页Suliman Khan Abdul Nasir 
supported by the Science and Technology Developmental Plan of Henan Province,China(232102520025);The National Foreign Expert Program of China(QN2022026001L).
Treating stroke or restoring brain function after stroke remains challenging for clinicians[1,2].Researchers have largely focused on developing neuroprotective strategies and translating these discoveries from rodent ...
关键词：protective NogoA CLINICAL 
Single-Cell Mapping of Brain Myeloid Cell Subsets Reveals Key Transcriptomic Changes Favoring Neuroplasticity after Ischemic Stroke
《Neuroscience Bulletin》2024年第1期65-78,共14页Fangxi Liu Xi Cheng Chuansheng Zhao Xiaoqian Zhang Chang Liu Shanshan Zhong Zhouyang Liu Xinyu Lin Wei Qiu Xiuchun Zhang 
supported by the National Natural Science Foundation of China(82071467);the International(Regional)Cooperation and Exchange Program of the National Natural Science Foundation of China(82111330075);the National Natural Science Foundation for Youth Scholars of China(81801053);the Innovation Team Support Plan of Universities in Liaoning Province(LT2019015);the Liaoning Provincial Key Research and Development Guidance Program(2019JH8/10300002);the Liaoning Revitalization Talents Plan(XLYC1802097).
Interactions between brain-resident and periph-eral infiltrated immune cells are thought to contribute to neuroplasticity after cerebral ischemia.However,con-ventional bulk sequencing makes it challenging to depict th...
关键词：Ischemic stroke Monocyte-derived macrophage Microglia Neurogenesis Single-cell sequencing 
The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke被引量：4
《Neuroscience Bulletin》2023年第9期1375-1395,共21页Yuxing Zhang Xin Zhao Chun Guo Ying Zhang Fukang Zeng Qian Yin Zhong Li Le Shao Desheng Zhou Lijuan Liu 
This work was supported by the National Natural Science Foundation for Young Scholars of China(82004346 and 82104766);the Natural Science Foundation of Hunan Province(2021JJ30521 and 2021JJ40424);the Open Fund for the First-class Discipline of Integrated Traditional Chinese and Western Medicine of Hunan University of Chinese Medicine(2020ZXYJH38 and 2020ZXYJH39);Natural Science Foundation of Changsha(kq2208202);the University-level Fund Project of Hunan University of Chinese Medicine(2021XJJJ039).
Ischemic stroke is a major public health problem worldwide.Although the circadian clock is involved in the process of ischemic stroke,the exact mechanism of the circadian clock in regulating angiogenesis after cerebra...
关键词：Circadian clock Ischemic stroke ANGIOGENESIS VEGF Notch pathway 
Brain Glycogen:An Angel or a Devil for Ischemic Stroke?被引量：1
《Neuroscience Bulletin》2023年第4期690-694,共5页Haiyun Guo Yumeng Li Wugang Hou Yanhui Cai 
supported by the National Natural Science Foundation of China(82001384 and 81901079);the Hygiene and Health Technology Program of Shaanxi Province of China(2022D001).
Brain Glycogen Works as an Angel Under Physiological Condition Glycogen Metabolism in the Brain One of the unique characteristics of the brain is its diversity in neural cell types,and neurons and astrocytes exhibit d...
关键词：metabolism CONSERVATIVE BRAIN 
A New Potential Strategy for Treatment of Ischemic Stroke:Targeting TRPM2–NMDAR Association被引量：2
《Neuroscience Bulletin》2023年第4期703-706,共4页Jiayun Xu Wei Zhang Jianhong Dong Liying Cao Zhihui Huang 
supported by grants from the Research Start-up Project by Hangzhou Normal University(4125C5021920435 and 4125C5021920453).
Ischemic stroke accounts for~85%of all strokes and generally occurs when blood flow is severely reduced due to clots or masses blocking blood vessels and cutting off blood flow to brain cells.The death or damage to ne...
关键词：ISCHEMIC PARALYSIS damage 
Updated Understanding of the Glial-Vascular Unit in Central Nervous System Disorders被引量：3
《Neuroscience Bulletin》2023年第3期503-518,共16页Di Yao Ruoying Zhang Minjie Xie Fengfei Ding Minghuan Wang Wei Wang 
supported by the Ministry of Science and Technology China Brain Initiative Grant(2022ZD0204704);the National Natural Science Foundation of China(81974180);the Young Excellent Medical Scholarship of Hubei Province(2020LJRCO11).
The concept of the glial-vascular unit(GVU)was raised recently to emphasize the close associations between brain cells and cerebral vessels,and their coordinated reactions to diverse neurological insults from a“glio-...
关键词：Glial-vascular unit Perivascular space Blood-brain barrier Glymphatic system Ischemic stroke Spinal cord injury Alzheimer's disease Major depression disorder 
Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke被引量：37
《Neuroscience Bulletin》2022年第10期1229-1247,共19页Rui Mao Ningning Zong Yujie Hu Ying Chen Yun Xu 
This review was supported by the National Natural Science Foundation of China(81920108017,82130036,and 81630028);the Key Research and Development Program of Jiangsu Province of China(BE2020620);Jiangsu Province Key Medical Discipline(ZDXKA2016020).
Ischemic stroke caused by intracranial vascular occlusion has become increasingly prevalent with considerable mortality and disability,which gravely burdens the global economy.Current relatively effective clinical tre...
关键词：Ischemic stroke Neuronal death MECHANISMS Therapeutic strategy 
Feature-based Quality Assessment of Middle Cerebral Artery Occlusion Using 18F-Fluorodeoxyglucose Positron Emission Tomography
《Neuroscience Bulletin》2022年第9期1057-1068,共12页Wuxian He Hongtu Tang Jia Li Chenze Hou Xiaoyan Shen Chenrui Li Huafeng Liu Weichuan Yu 
supported by R4012-18,C6021-19EF and GRF 16306919 from the Research Grant Council(RGC);ITS/480/18FP and MHP/033/20;from the Innovation and Technology Commission(ITC)of the Hong Kong S.A.R.,Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone Projec(HZQB-KCZYB-2020083);the National Natural Science Foundation of China(U1809204);the Talent Program of Zhejiang Province(2021R51004)。
In animal experiments,ischemic stroke is usually induced through middle cerebral artery occlusion(MCAO),and quality assessment of this procedure is crucial.However,an accurate assessment method based on 18F-fluorodeox...
关键词：Ischemic stroke Middle cerebral artery occlusion Brain metabolism FDG PET imaging SIFT classification 
Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke被引量：3
《Neuroscience Bulletin》2021年第5期725-728,共4页Yuzhu Wang Dan Tian Yushang Zhao Mengyao Qu Yuhualei Pan Changwei Wei Yanbing Zhu Anshi Wu 
supported by the National Natural Science Foundation of China (81771139);Beijing Natural Science Foundation (7194270)。
Dear Editor,Emergency intravascular thrombectomy is the best treatment for acute ischemic stroke [1]. However, it is controversial whether the use of general anesthesia during emergency intravascular thrombectomy affe...
关键词：ANESTHESIA acute INTRAVASCULAR 
Macrophage-NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes被引量：12
《Neuroscience Bulletin》2020年第9期1035-1045,共11页Hong-Bin Lin Guan-Shan Wei Feng-Xian Li Wen-Jing Guo Pu Hong Ya-Qian Weng Qian-Qian Zhang Shi-Yuan Xu Wen-Bin Liang Zhi-Jian You Hong-Fei Zhang 
supported by grants from the National Natural Science Foundation of China (81771232 and 81974192);the Natural Science Foundation of Guangdong Province,China (2019A1515010654)。
Ischemic stroke is one of the leading causes of death worldwide.In the post-stroke stage,cardiac dysfunction is common and is known as the brain-heart interaction.Diabetes mellitus worsens the post-stroke outcome.Stro...
关键词：Ischemic stroke Diabetes mellitus Cardiac dysfunction NLRP3 inflammasome MACROPHAGE 
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