ISCHEMIC_STROKE

作品数：674被引量：2883H指数：25
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相关作者：张祥建陈林玉祝春华乔会敏虞珊珊更多>>
相关机构：河北医科大学第二医院中南大学上海市东方医院四川大学华西医院更多>>
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Fibrotic scar formation after cerebral ischemic stroke:Targeting the Sonic hedgehog signaling pathway for scar reduction
《Neural Regeneration Research》2026年第2期756-768,共13页un Wen Hao Tang Mingfen Tian Ling Wang Qinghuan Yang Yong Zhao Xuemei Li Yu Ren Jiani Wang Li Zhou Yongjun Tan Haiyun Wu Xinrui Cai Yilin Wang Hui Cao Jianfeng Xu Qin Yang 
supported by the National Natural Science Foundation of China,Nos.82171456(to QY)and 81971229(to QY);the Natural Science Foundation of Chongqing,Nos.CSTC2021JCYJ-MSXMX0263(to QY)and CSTB2023NSCQ-MSX1015(to XL);Doctoral Innovation Project of The First Affiliated Hospital of Chongqing Medical University,Nos.CYYY-BSYJSCXXM-202318(to JW)and CYYY-BSYJSCXXM-202327(to HT).
Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment.However,little is known about how fibrosis is induced and regulated after...
关键词：central nervous system FIBROBLASTS fibrosis ischemic stroke Mitofusin 2 middle cerebral artery occlusion/reperfusion P-Smad3 Sonic Hedgehog SMAD3 TOM20 
Microglial intervention in ischemic stroke:Roles and intervention strategies
《Neural Regeneration Research》2026年第2期443-454,共12页Cuiling Ji Lixinbei Sheng Kaijun Han Ping Yuan Wei Li Lu Chen Yongyue Gao 
supported by the National Natural Science Foundation of China,82471345(to LC);the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...
关键词：blood-brain barrier ischemic stroke MICROGLIA nerve regeneration NEUROINFLAMMATION NEUROPROTECTION oxidative stress polarization signaling pathways therapeutic strategies 
Tryptophan metabolism and ischemic stroke:An intricate balance
《Neural Regeneration Research》2026年第2期466-477,共12页Chongjie Yao Dong Xie Yuchen Zhang Yuanhao Shen Pingping Sun Zhao Ma Jin Li Jiming Tao Min Fang 
supported by Shanghai Shenkang Center Demonstration Research Ward Construction,No.SHDC2022CRW010(to MF);Shanghai Shenkang Center Medical Enterprise Integration and Innovation Collaborative Special Project,No.SHDC2022CRT018(to MF);Shanghai Health System Key Supported Discipline-Rehabilitation Medicine,No.2023ZDFC0301(to JT);Science and Technology Development Project of Shanghai University of Traditional Chinese Medicine,No.23KFL009(to JT);Shanghai Postdoctoral Excellence Program,No.2022515(to CY);Yangfan Special Project of Shanghai Science and Technology Innovation Action Plan,No.23YF1447600(to CY);China Postdoctoral Science Foundation,No.2023M732338(to CY).
Ischemic stroke,which is characterized by hypoxia and ischemia,triggers a cascade of injury responses,including neurotoxicity,inflammation,oxidative stress,disruption of the blood-brain barrier,and neuronal death.In t...
关键词：5-HYDROXYTRYPTAMINE cerebral ischemia ischemic stroke KYNURENINE neuroprotection NEUROTOXICITY post-stroke cognitive impairment post-stroke depression SEROTONIN tryptophan metabolism 
Tropism-shifted AAV-PHP.eB-mediated bFGF gene therapy promotes varied neurorestoration after ischemic stroke in mice
《Neural Regeneration Research》2026年第2期704-714,共11页Rubing Shi Jing Ye Ze Liu Cheng Wang Shengju Wu Hui Shen Qian Suo Wanlu Li Xiaosong He Zhijun Zhang Yaohui Tang Guo-Yuan Yang Yongting Wang 
supported by the National Natural Science Foundation of China,Nos.81870921(to YW),81974179(to ZZ),82271320(to ZZ),82071284(to YT);National Key R&D Program of China,No.2022YFA1603600(to ZZ),2019YFA0112000(to YT);Scientific Research and Innovation Program of Shanghai Education Commission,No.2019-01-07-00-02-E00064(to GYY);Scientific and Technological Innovation Act Program of Shanghai Science and Technology Commission,No.20JC1411900(to GYY).
AAV-PHP.eB is an artificial adeno-associated virus(AAV)that crosses the blood-brain barrier and targets neurons more efficiently than other AAVs when administered systematically.While AAV-PHP.eB has been used in vario...
关键词：AAV-PHP.eB angiogenesis basic fibroblast growth factor gene therapy ischemic stroke Ly6A neurogenesis neurological function transient middle cerebral artery occlusion TROPISM 
Enhanced neurogenesis after ischemic stroke:The interplay between endogenous and exogenous stem cells
《Neural Regeneration Research》2026年第1期212-223,共12页Ruxu Geng Yuhe Wang Renzhi Wang Jun Wu Xinjie Bao 
supported by the National Key Research and Development Program of China,No.2018YFA0108602;the CAMS Initiative for Innovative Medicine,No.2021-1-I2M-019;National High-Level Hospital Clinical Research Funding,No.2022-PUMCH-C-042(all to XB)。
Ischemic stroke is a significant global health crisis,frequently resulting in disability or death,with limited therapeutic interventions available.Although various intrinsic reparative processes are initiated within t...
关键词：brain-derived neurotrophic factor endogenous neuroregeneration exosomes hydrogels ischemic stroke mesenchymal stem cells neural stem cells NEUROGENESIS stem cell transplantation 
Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes:potential targets for neural repair in neurological diseases
《Neural Regeneration Research》2025年第12期3349-3369,共21页Yichen Peng Li Zhou Yaju Jin Danli Wu Na Chen Chengcai Zhang Hongpeng Liu Chunlan Li Rong Ning Xichen Yang Qiuyue Mao Jiaxin Liu Pengyue Zhang 
supported by Yunnan Province Innovation Team of Prevention and Treatment for Brain Disease with Acupuncture and Tuina,No.202405AS350007;Youth Top Talent Project of 10-thousand Talent Plan in Yunnan Province,No.YNWR-QNBJ-2018-345;the National Natural Science Foundation of China,No.81960731;Joint Special Project of Traditional Chinese Medicine in Science and Technology Department of Yunnan Province,Nos.2019FF002[-008],202001AZ070001-002 and 202001AZ070001-030;Yunnan Province University Innovation Team Projects No.2019YGC04;Yunnan Province Project Education Fund,Nos.2024Y406,2024Y414(all to PZ)。
The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels.Mitochondria-associated endoplasmic reticulum membranes serve as ph...
关键词：Alzheimer’s disease amyotrophic lateral sclerosis Ca^(2+)signaling conduction Huntington’s disease ischemic stroke MAMMALS mitochondrial dynamics neural function repair oxidative stress Parkinson’s disease traumatic brain injury 
Corrigendum: Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke
《Neural Regeneration Research》2025年第12期3429-3429,共1页
Epigenetic regulation of the inflammatory response in stroke
《Neural Regeneration Research》2025年第11期3045-3062,共18页Jingyi Liang Fei Yang Zixiao Li Qian Li 
supported by the National Natural Science Foundation of China,Nos.32070735(to QL),82371321(to QL),82171270(to ZL);Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1(to ZL);the Natural Science Foundation of Beijing,No.Z200016(to ZL);Beijing Talents Project,No.2018000021223ZK03(to ZL);Beijing Municipal Committee of Science and Technology,No.Z201100005620010(to ZL)。
Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either type.Immunologic mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytoki...
关键词：DNA methylation histone modification intracerebral hemorrhage ischemic stroke NEUROINFLAMMATION NEUROPROTECTION non-coding RNA RNA methylation subarachnoid hemorrhage treatment 
Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases
《Neural Regeneration Research》2025年第11期3076-3094,共19页Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng Luo 
supported by the National Natural Science Foundation of China,Nos.82171363,82371381(to PL),82171458(to XJ);Key Research and Development Project of Shaa nxi Province,Nos.2024SF-YBXM-404(to KY)。
Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological diseases.Owing to their therapeutic properties and ability to cross the blood–b...
关键词：Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles GLIOMA ischemic stroke neurological diseases Parkinson's disease PSYCHOSIS targeted drug delivery traumatic brain injury 
Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway
《Neural Regeneration Research》2025年第11期3245-3258,共14页Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu 
supported by the National Nature Science Foundation of China,No.81471308(to JL);the Innovative Leading Talents of Liaoning Province,No.XLYC1902031(to JL);Science and Technology Projects in Liaoning Province,No.2022-BS-238(to CH);Young Top Talents of Liaoning Province,No.XLYC1907009(to LW);Dalian Science and Technology Innovation Fund,No.2018J11CY025(to JL)。
Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem ce...
关键词：behavior EXOSOME extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT) 
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