ISCHEMIC_STROKE

作品数:655被引量:2857H指数:25
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相关作者:张祥建陈林玉祝春华乔会敏虞珊珊更多>>
相关机构:河北医科大学第二医院中南大学上海市东方医院四川大学华西医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes:potential targets for neural repair in neurological diseases
《Neural Regeneration Research》2025年第12期3349-3369,共21页Yichen Peng Li Zhou Yaju Jin Danli Wu Na Chen Chengcai Zhang Hongpeng Liu Chunlan Li Rong Ning Xichen Yang Qiuyue Mao Jiaxin Liu Pengyue Zhang 
supported by Yunnan Province Innovation Team of Prevention and Treatment for Brain Disease with Acupuncture and Tuina,No.202405AS350007;Youth Top Talent Project of 10-thousand Talent Plan in Yunnan Province,No.YNWR-QNBJ-2018-345;the National Natural Science Foundation of China,No.81960731;Joint Special Project of Traditional Chinese Medicine in Science and Technology Department of Yunnan Province,Nos.2019FF002[-008],202001AZ070001-002 and 202001AZ070001-030;Yunnan Province University Innovation Team Projects No.2019YGC04;Yunnan Province Project Education Fund,Nos.2024Y406,2024Y414(all to PZ)。
The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels.Mitochondria-associated endoplasmic reticulum membranes serve as ph...
关键词:Alzheimer’s disease amyotrophic lateral sclerosis Ca^(2+)signaling conduction Huntington’s disease ischemic stroke MAMMALS mitochondrial dynamics neural function repair oxidative stress Parkinson’s disease traumatic brain injury 
Corrigendum: Neuroprotection by cattle encephalon glycoside and ignotin beyond the time window of thrombolysis in ischemic stroke
《Neural Regeneration Research》2025年第12期3429-3429,共1页
Epigenetic regulation of the inflammatory response in stroke
《Neural Regeneration Research》2025年第11期3045-3062,共18页Jingyi Liang Fei Yang Zixiao Li Qian Li 
supported by the National Natural Science Foundation of China,Nos.32070735(to QL),82371321(to QL),82171270(to ZL);Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1(to ZL);the Natural Science Foundation of Beijing,No.Z200016(to ZL);Beijing Talents Project,No.2018000021223ZK03(to ZL);Beijing Municipal Committee of Science and Technology,No.Z201100005620010(to ZL)。
Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either type.Immunologic mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytoki...
关键词:DNA methylation histone modification intracerebral hemorrhage ischemic stroke NEUROINFLAMMATION NEUROPROTECTION non-coding RNA RNA methylation subarachnoid hemorrhage treatment 
Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases
《Neural Regeneration Research》2025年第11期3076-3094,共19页Xinyu Yang Xiangyu Gao Xiaofan Jiang Kangyi Yue Peng Luo 
supported by the National Natural Science Foundation of China,Nos.82171363,82371381(to PL),82171458(to XJ);Key Research and Development Project of Shaa nxi Province,Nos.2024SF-YBXM-404(to KY)。
Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological diseases.Owing to their therapeutic properties and ability to cross the blood–b...
关键词:Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles GLIOMA ischemic stroke neurological diseases Parkinson's disease PSYCHOSIS targeted drug delivery traumatic brain injury 
PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives
《Neural Regeneration Research》2025年第10期2758-2775,共18页Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna Liu Yi Ding 
supported by the National Natural Science Foundation of China,Nos.82274313(to YD),82204746(to ML),82003982(to TL).
It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing a...
关键词:apoptosis autophagy inflammation ischemic stroke NEUROPROTECTION oxidative stress PATHOGENESIS phosphatidylinositol 3-kinase protein kinase B THERAPEUTICS 
Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials
《Neural Regeneration Research》2025年第9期2437-2453,共17页Siyi Xu Junqiu Jia Rui Mao Xiang Cao Yun Xu 
supported by the National Natural Science Foundation of China,Nos.81920108017(to YX),82130036(to YX),82371326(to XC),82171310(to XC);the STI2030-Major Projects,No.2022ZD0211800(to YX);Jiangsu Province Key Medical Discipline,No.ZDXK202216(to YX)。
Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal ...
关键词:autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control MITOPHAGY spinal cord injury subarachnoid hemorrhage traumatic brain injury 
Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment
《Neural Regeneration Research》2025年第9期2598-2610,共13页Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu 
supported by the Scientific Research Project of China Rehabilitation Research Center,No.2021zx-23;the National Natural Science Foundation of China,No.32100925;the Beijing Nova Program,No.Z211100002121038。
Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this condition.The aims of this study were to...
关键词:BIOMARKER high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment 
Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery
《Neural Regeneration Research》2025年第8期2181-2198,共18页Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao 
supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW);the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...
关键词:delivery engineering extracellular vesicles identification ischemic stroke isolation MITOCHONDRIA targeting strategy therapeutic effects 
In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke被引量:1
《Neural Regeneration Research》2025年第8期2309-2310,共2页Takashi Irie Taito Matsuda 
supported by JSPS KAKENHI Grant Number JP24K18622(to TI);JSPS KAKENHI Grant Number JP23K18451(to TM)。
Stroke causes neuronal loss,which ultimately results in persistent neurological dysfunction.Globally,stroke was the third-leading cause of death and disability combined in all ages in 2019,after neonatal disorders and...
关键词:NEONATAL DEATH THERAPEUTIC 
Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke
《Neural Regeneration Research》2025年第7期1944-1956,共13页Julia Castillo-González Elena González-Rey 
supported by the grants from the Spanish Ministry of Economy and Competitiveness(SAF2017-85602-R);the Spanish Ministry of Science and Innovation(PID2020-119638RB-I00 to EGR);FPU-program(FPU17/02616 to JCG)。
The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral circulation.It tightly modulates the ion transport and nutrient influx,while restricting...
关键词:blood–brain barrier disruption drug delivery ischemic stroke NEUROINFLAMMATION tight-junctions 
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